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Details

Stereochemistry RACEMIC
Molecular Formula C6H8N2O2
Molecular Weight 140.1399
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIMIRACETAM

SMILES

O=C1CN2C(CCC2=O)N1

InChI

InChIKey=XTXXOHPHLNROBN-UHFFFAOYSA-N
InChI=1S/C6H8N2O2/c9-5-3-8-4(7-5)1-2-6(8)10/h4H,1-3H2,(H,7,9)

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/8277504 | https://www.ncbi.nlm.nih.gov/pubmed/24898652 | http://adisinsight.springer.com/drugs/800027387

Dimiracetam is a nootropic drug of the racetam family. Dimiracetam inhibited the NMDA-induced increase of [3H]D-Asp release from hippocampal synaptosomes. The increased potency and longer duration of action of dimiracetam, together with the potential cognition enhancing property makes it a very promising and safe for the treatment of neuropathic pain conditions for which there are very limited therapeutic options. Dimiracetam is in Phase II clinical trials for the treatment of HIV-associated pain and in phase I clinical trials for the treatment of osteoarthritis pain.

CNS Activity

Originator

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2849
 1.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Phase II
1147
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY515179
https://www.001chemical.com/chem/126100-97-8
AA Blocks
AA009HR6
http://www.aablocks.com/goods/Goods/detail?id=AA009HR6
Aaron Chemicals
AR009IIY
http://www.aaronchem.com/126100-97-8
abcr GmbH
AB513006
http://www.abcr.com/shop/en/AB513006
AHH Chemical co.,ltd
MR-1013846
http://www.ahhchemical.com/product/MR-1013846.html
Alichem
69003895
http://www.alichem.com/en/products/126100-97-8.html
Aurora Fine Chemicals LLC
A31.013.147
http://online.aurorafinechemicals.com/info?ID=A31.013.147
BLD Pharm
BD125647
http://www.bldpharm.com/products/126100-97-8.html
Chem Scene
CS-0026742
http://www.chemscene.com/126100-97-8.html
ChemShuttle
182368
http://www.chemshuttle.com/catalogsearch/result/?q=126100-97-8&cat=
Chemspace
CSSB00000076864
https://chem-space.com/CSSB00000076864
eNovation Chemicals
D677371
https://www.enovationchem.com/ProductDetails.asp?ProductID=D677371
eNovation Chemicals
D762244
https://www.enovationchem.com/ProductDetails.asp?ProductID=D762244
Molcore
MC515179
https://www.molcore.com/product/126100-97-8
MolPort
MolPort-038-354-205
https://www.molport.com/shop/molecule-link/MolPort-038-354-205
MuseChem
M109243
https://www.musechem.com/product/M109243.html
Smolecule
S526207
http://www.smolecule.com/products/s526207
Synblock Inc
SB17242
http://www.synblock.com/product/126100-97-8.html
THE BioTek
bt-265115
https://www.thebiotek.com/product/inhibitors/bt-265115
PubMed

PubMed

TitleDatePubMed
Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain.
2008-03-15
Synthesis and pharmacological activity of a series of dihydro-1H-pyrrolo[1,2-a]imidazole-2,5(3H,6H)-diones, a novel class of potent cognition enhancers.
1993-12-24
Patents

Patents

US7989421
1
WO2012013640A1
1

Sample Use Guides

In Vivo Use Guide
400 mg b.i.d. and doubling the dose every two weeks until a maximum of 1600 mg b.i.d. (8 weeks treatment).
Route of Administration: Oral
In Vitro Use Guide
Dimiracetam proved to be even more potent in the spinal cord, as the NMDA-induced increase of [3H]D-Asp release was already completely abolished at 1 uM.
Name Type Language
NT-11624
Preferred Name English
DIMIRACETAM
INN  
INN  
Official Name English
1H-PYRROLO(1,2-A)IMIDAZOLE-2,5(3H,6H)-DIONE, DIHYDRO-
Systematic Name English
(±)-DIHYDRO-1H-PYRROLO(1,2-A)IMIDAZOLE-2,5(3H,6H)-DIONE
Systematic Name English
DIHYDRO-1H-PYRROLO(1,2-A)IMIDAZOLE-2,5(3H,6H)-DIONE
Systematic Name English
NT11624
Code English
dimiracetam [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1509
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C79121
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
EPA CompTox
DTXSID20869732
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
EVMPD
SUB07186MIG
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
MESH
C085079
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
FDA UNII
4AW7F70MZO
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
ChEMBL
CHEMBL337612
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
INN
7033
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
PUBCHEM
65955
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
DRUG BANK
DB13018
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
WIKIPEDIA
DIMIRACETAM
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
CAS
126100-97-8
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
SMS_ID
100000082668
Created by admin on Wed Apr 02 07:44:39 GMT 2025 , Edited by admin on Wed Apr 02 07:44:39 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of DIMIRACETAM
NIH
NCATS
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DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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