Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C27H36N6O3 |
| Molecular Weight | 492.6131 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(OC)C=C2C(NCCN3CCOCC3)=NC(=NC2=C1)C4=CC=C(C=C4)N5CCN(C)CC5
InChI
InChIKey=TUOZJWZCVIRDKO-UHFFFAOYSA-N
InChI=1S/C27H36N6O3/c1-31-10-12-33(13-11-31)21-6-4-20(5-7-21)26-29-23-19-25(35-3)24(34-2)18-22(23)27(30-26)28-8-9-32-14-16-36-17-15-32/h4-7,18-19H,8-17H2,1-3H3,(H,28,29,30)
Approval Year
| Name | Type | Language | ||
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Common Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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5TVM84YK6F
Created by
admin on Sat Dec 16 11:36:40 UTC 2023 , Edited by admin on Sat Dec 16 11:36:40 UTC 2023
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PRIMARY | |||
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CPG-52364
Created by
admin on Sat Dec 16 11:36:40 UTC 2023 , Edited by admin on Sat Dec 16 11:36:40 UTC 2023
|
PRIMARY | Description: CPG-52364 a small molecule TLR7/8/9 antagonist, has recently completed phase 1 clinical trial for SLE therapy. Toll-like receptors (TLRs) are a family of type I transmembrane receptors and the central components of the innate immune system. Human TLR3, TLR7, TLR8, and TLR9 are expressed on endosomal membranes in the cells and recognize pathogenderived nucleic acid molecular patterns.5 However, recognition of endogenous immune complexes containing self-nucleic acids as PAMPs or DAMPs contributes to certain autoimmune diseases, such as systemic lupus erythematosus (SLE), psoriasis,7 arthritis, and multiple sclerosis.8 Therefore, inhibition of these recognition signals is expected to have therapeutic value. (last updated: 11/11/2015). | ||
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25105690
Created by
admin on Sat Dec 16 11:36:40 UTC 2023 , Edited by admin on Sat Dec 16 11:36:40 UTC 2023
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PRIMARY | |||
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1093135-60-4
Created by
admin on Sat Dec 16 11:36:40 UTC 2023 , Edited by admin on Sat Dec 16 11:36:40 UTC 2023
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PRIMARY |
ACTIVE MOIETY
