APD-668

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NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H24FN5O5S
Molecular Weight	477.509
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of APD-668

Structure Search

SMILES

CC(C)OC(=O)N1CCC(CC1)OC2=NC=NC3=C2C=NN3C4=C(F)C=C(C=C4)S(C)(=O)=O

InChI

InChIKey=XTRUQJBVQBUKSQ-UHFFFAOYSA-N

InChI=1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3

HIDE SMILES / InChI

Approval Year

Name

Type

Language

APD-668

Code

English

4-((1-(2-FLUORO-4-METHYLSULFONYLPHENYL)-1H-PYRAZOLO(3,4-D)PYRIMIDIN-4-YL)OXY)PIPERIDINE-1-CARBOXYLIC ACID ISOPROPYL ESTER

Systematic Name

English

PROPAN-2-YL 4-(1-(2-FLUORO-4-METHYLSULFONYLPHENYL)PYRAZOLO(4,5-E)PYRIMIDIN-4-YL)OXYPIPERIDINE-1-CARBOXYLATE

Systematic Name

English

1-PIPERIDINECARBOXYLIC ACID, 4-((1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO(3,4-D)PYRIMIDIN-4-YL)OXY)-, 1-METHYLETHYL ESTER

Systematic Name

English

ISOPROPYL 4-((1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO(3,4-D)PYRIMIDIN-4-YL)OXY)-1-PIPERIDINECARBOXYLATE

Systematic Name

English

APD668

Code

English

1-METHYLETHYL 4-((1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO(3,4-D)PYRIMIDIN-4-YL)OXY)-1-PIPERIDINECARBOXYLATE

Systematic Name

English

JNJ-28630368

Code

English

Code System Code Type Description

PUBCHEM

11705608

Created by admin on Sat Dec 16 11:31:13 UTC 2023 , Edited by admin on Sat Dec 16 11:31:13 UTC 2023

PRIMARY

FDA UNII

JC77BCH2AP

Created by admin on Sat Dec 16 11:31:13 UTC 2023 , Edited by admin on Sat Dec 16 11:31:13 UTC 2023

PRIMARY

EPA CompTox

DTXSID701025686

Created by admin on Sat Dec 16 11:31:13 UTC 2023 , Edited by admin on Sat Dec 16 11:31:13 UTC 2023

PRIMARY

CAS

832714-46-2

Created by admin on Sat Dec 16 11:31:13 UTC 2023 , Edited by admin on Sat Dec 16 11:31:13 UTC 2023

PRIMARY

MANUFACTURER PRODUCT INFORMATION

APD-668

Created by admin on Sat Dec 16 11:31:13 UTC 2023 , Edited by admin on Sat Dec 16 11:31:13 UTC 2023

PRIMARY

JNJ-28630368: GPR119, a glucose-dependent insulinotropic receptor, is a G protein-coupled receptor that is expressed in pancreatic .BETA.-cells and intestinal L-cells.1 Activation of GPR119 by the endogenous ligands lyso-phosphatidylcholine (Item No. 10172) and oleoyl ethanolamide (Item No. 90265) increases intracellular cAMP levels and promotes glucose-stimulated insulin secretion.1,2 APD668 is a potent agonist of GPR119 (EC50s = 2.7 and 33 nM for human and rat forms, respectively).3 Chronic dosing with APD668 in Zucker diabetic fatty rats over several weeks significantly reduces blood glucose and glycated hemoglobin levels.

ACTIVE MOIETY


					JC77BCH2AP

APD-668