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Details

Stereochemistry ABSOLUTE
Molecular Formula C27H41F2N5O
Molecular Weight 489.6441
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NIROGACESTAT

SMILES

CCC[C@H](N[C@H]1CCC2=C(C1)C(F)=CC(F)=C2)C(=O)NC3=CN(C=N3)C(C)(C)CNCC(C)(C)C

InChI

InChIKey=VFCRKLWBYMDAED-REWPJTCUSA-N
InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1

HIDE SMILES / InChI

Approval Year

Unknown
123738
Name Type Language
NIROGACESTAT
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
PF-03084014
Code English
(S)-2-(((S)-6,8-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL)AMINO)-N-(1-(2-METHYL-1-(NEOPENTYLAMINO)PROPAN-2-YL)-1H-IMIDAZOL-4-YL)PENTANAMIDE
Systematic Name English
NIROGACESTAT [USAN]
Common Name English
PENTANAMIDE, 2-(((2S)-6,8-DIFLUORO-1,2,3,4-TETRAHYDRO-2-NAPHTHALENYL)AMINO)-N-(1-(2-((2,2-DIMETHYLPROPYL)AMINO)-1,1-DIMETHYLETHYL)-1H-IMIDAZOL-4-YL)-, (2S)-
Systematic Name English
(2S)-2-(((2S)-6,8-DIFLUORO-1,2,3,4-TETRAHYDRO-2-NAPHTHALENYL)AMINO)-N-(1-(2-((2,2-DIMETHYLPROPYL)AMINO)-1,1-DIMETHYLETHYL)-1H-IMIDAZOL-4-YL)PENTANAMIDE
Systematic Name English
PF 3084014
Code English
PF 03084014
Code English
nirogacestat [INN]
Common Name English
Nirogacestat [WHO-DD]
Common Name English
PF-3084014
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 636518
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL1770916
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
PRIMARY
USAN
CD-151
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
PRIMARY
DRUG BANK
DB12005
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
PRIMARY
CAS
1290543-63-3
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
PRIMARY
FDA UNII
QZ62892OFJ
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
PRIMARY
CAS
865773-15-5
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
NON-SPECIFIC STEREOCHEMISTRY
PUBCHEM
46224413
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
PRIMARY
WIKIPEDIA
Nirogacestat
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
PRIMARY
SMS_ID
100000174650
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
PRIMARY
NCI_THESAURUS
C82383
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
PRIMARY
INN
10404
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
PRIMARY
EPA CompTox
DTXSID60235679
Created by admin on Sat Dec 16 05:41:04 UTC 2023 , Edited by admin on Sat Dec 16 05:41:04 UTC 2023
PRIMARY
ACTIVE MOIETY
Structure of NIROGACESTAT
SALT/SOLVATE (PARENT)
Structure of NIROGACESTAT HYDROBROMIDE
NIH
NCATS
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