RHO-ASSOCIATED PROTEIN KINASE 2

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 19:09:54 GMT 2025` Edited by `admin` on `Tue Apr 01 19:09:54 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	0JQ7O17JE9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RHO-ASSOCIATED PROTEIN KINASE 2

Common Name

English

KIAA0619

Preferred Name

English

RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE II

Common Name

English

ROCK-II

Common Name

English

RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE 2

Common Name

English

RHO KINASE 2

Common Name

English

ROCK2

Common Name

English

P164 ROCK-2

Common Name

English

Code System Code Type Description

FDA UNII

0JQ7O17JE9

Created by admin on Tue Apr 01 19:09:54 GMT 2025 , Edited by admin on Tue Apr 01 19:09:54 GMT 2025

PRIMARY

UNIPROT

O75116

Created by admin on Tue Apr 01 19:09:54 GMT 2025 , Edited by admin on Tue Apr 01 19:09:54 GMT 2025

PRIMARY

PHAROS

O75116

Created by admin on Tue Apr 01 19:09:54 GMT 2025 , Edited by admin on Tue Apr 01 19:09:54 GMT 2025

PRIMARY

Linkage Type	Residue Index
ZINC FINGER	1_1260	1_1315

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Comments:

ROCK2 selective inhibitor

Amount:


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Comments:

INHIBITION OF THE PHOSPHORYLTRANSFERASE ACTIVITY OF THE KINASE

Interaction Type:

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Qualification:

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Amount:


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Qualification:

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Amount:


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Amount:


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Comments:

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Qualification:

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Amount:


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Comments:

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Qualification:

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Amount:

Structural Modifications

Modification Type	Location Site	Residue Modified	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_1137] [1_1374]	SERINE	DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_722]	TYROSINE	TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID SUBSTITUTION	[1_414]	THREONINE	THREONINE PHOSPHATE	3L4WX7B1EI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL