PYRUVATE KINASE PKR

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 19:55:25 GMT 2025` Edited by `admin` on `Tue Apr 01 19:55:25 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	11F03GK3UH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PYRUVATE KINASE PKR

Common Name

English

PYRUVATE KINASE 1

Preferred Name

English

PYRUVATE KINASE RED BLOOD CELL

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 862.1650

Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025

Code System Code Type Description

CAS

625326-52-5

Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025

ALTERNATIVE

WIKIPEDIA

PKLR

Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025

PRIMARY

EC (ENZYME CLASS)

EC 2.7.1.40

Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025

PRIMARY

CAS

479853-13-9

Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025

PRIMARY

UNIPROT

P30613

Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025

PRIMARY

CAS

391970-89-1

Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025

ALTERNATIVE

FDA UNII

11F03GK3UH

Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025

PRIMARY

Related Record Type Details


					WLI3QP8XYK

PKR-IN-2

ACTIVATOR -> TARGET

Qualification:

EC50

Amount:


					V4E0A9M44Q

ACTIVATOR -> TARGET

Comments:

activator to 89% of activity

Qualification:

EC50

Amount:


					2WTV10SIKH

MITAPIVAT

ACTIVATOR -> TARGET

Comments:

519% activation over baseline

Interaction Type:

ALLOSTERIC

Qualification:

EC50

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REPLACEMENT	[1_148] [2_418] [3_418] [4_418]		TYROSINE		TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID REPLACEMENT	[1_105] [1_313] [1_365] [2_105] [2_313] [2_365] [3_105] [3_313] [3_365] [4_105] [4_313] [4_365]		LYSINE		N6-SUCCINYLLYSINE	3LH35AJA5L
AMINO ACID REPLACEMENT	[1_2] [1_19] [1_26] [1_43] [1_140] [1_292] [2_2] [2_19] [2_26] [2_43] [2_140] [2_292] [3_2] [3_19] [3_26] [3_43] [3_140] [3_292] [4_2] [4_19] [4_26] [4_43] [4_140] [4_292]		SERINE		DEXFOSFOSERINE	VI4F0K069V
AMINO ACID REPLACEMENT	[1_109] [1_365] [1_541] [2_109] [2_365] [2_541] [3_109] [3_365] [3_541] [4_109] [4_365] [4_541]		LYSINE		N6-SUCCINYLLYSINE	3LH35AJA5L

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL