RHODODENDROL, (±)-

Details

Stereochemistry	RACEMIC
Molecular Formula	C10H14O2
Molecular Weight	166.217
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(O)CCC1=CC=C(O)C=C1

InChI

InChIKey=SFUCGABQOMYVJW-UHFFFAOYSA-N

InChI=1S/C10H14O2/c1-8(11)2-3-9-4-6-10(12)7-5-9/h4-8,11-12H,2-3H2,1H3

HIDE SMILES / InChI

Molecular Formula	C10H14O2
Molecular Weight	166.217
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26613259 | https://www.ncbi.nlm.nih.gov/pubmed/26547111 | https://www.ncbi.nlm.nih.gov/pubmed/24890809 | https://www.ncbi.nlm.nih.gov/pubmed/26867644 | https://www.ncbi.nlm.nih.gov/pubmed/25726326

Rhododendrol, 4-(4-hydroxyphenyl)-2-butanol, Rhododenol(®) (RD), a naturally occurring phenolic compound, was developed as a tyrosinase inhibitor for skin-lightening/whitening cosmetics. In 2013, skin depigmentation was reported in consumers using RD-containing skin-brightening cosmetics; this condition is called RD-induced leukoderma. Rhododendrol exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism. It has being shown to impair the normal proliferation of melanocytes through reactive oxygen species-dependent activation of GADD45. Rhododendrol (RD) is a potent tyrosinase inhibitor.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Tyrosinase 41 Target ID: CHEMBL3318 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27174091 \| https://www.ncbi.nlm.nih.gov/pubmed/26970333 \| https://www.ncbi.nlm.nih.gov/pubmed/26847926 \| https://www.ncbi.nlm.nih.gov/pubmed/25726326	Inhibitor 8504		244.6 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Melanoma 88 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26613259 https://www.ncbi.nlm.nih.gov/pubmed/24890809	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Rhododenol-induced leukoderma in a mouse model mimicking Japanese skin.	2016-01	26547111
Different effects of five depigmentary compounds, rhododendrol, raspberry ketone, monobenzone, rucinol and AP736 on melanogenesis and viability of human epidermal melanocytes.	2016-01	26440747
T-Cell Responses to Tyrosinase-Derived Self-Peptides in Patients with Leukoderma Induced by Rhododendrol: Implications for Immunotherapy Targeting Melanoma.	2016	26613259

Patents

Sample Use Guides

In Vivo Use Guide

Mice: two-hundred microliters of 30% Rhododendrol (RD) solution was applied on the back of five albino mice.

Route of Administration: Topical

In Vitro Use Guide

10 mM of Rhododendrol induced significant apoptosis in normal human melanocytes (NHMs) after 15 h.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:58:26 GMT 2025` Edited by `admin` on `Mon Mar 31 20:58:26 GMT 2025`
Record UNII	12QWN45UL0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RHODODENDROL

Preferred Name

English

RHODODENDROL, (±)-

Common Name

English

BENZENEPROPANOL, 4-HYDROXY-.ALPHA.-METHYL-

Systematic Name

English

RASPBERRY ALCOHOL [USP-RS]

Common Name

English

FRAMBINOL

Common Name

English

4-(3-HYDROXYBUTYL)PHENOL

Systematic Name

English

RASPBERRY ALCOHOL

Common Name

English

RASPBERRY ALCOHOL [USP IMPURITY]

Common Name

English

(±)-RHODODENDROL

Common Name

English

RACTOPAMINE HYDROCHLORIDE SUSPENSION IMPURITY, RASPBERRY ALCOHOL- [USP IMPURITY]

Common Name

English

NSC-40514

Code

English

4-(P-HYDROXYPHENYL)-2-BUTANOL

Common Name

English

Classification Tree Code System Code

DSLD

1936 (Number of products:1)