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Details

Stereochemistry ABSOLUTE
Molecular Formula C17H23N5O2.ClH
Molecular Weight 365.858
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SUNEPITRON HYDROCHLORIDE

SMILES

Cl.O=C1CCC(=O)N1C[C@H]2CC[C@H]3CN(CCN3C2)C4=NC=CC=N4

InChI

InChIKey=HWGPYTRJVVMHGT-IODNYQNNSA-N
InChI=1S/C17H23N5O2.ClH/c23-15-4-5-16(24)22(15)11-13-2-3-14-12-21(9-8-20(14)10-13)17-18-6-1-7-19-17;/h1,6-7,13-14H,2-5,8-12H2;1H/t13-,14-;/m0./s1

HIDE SMILES / InChI
Molecular Formula C17H23N5O2
Molecular Weight 329.3968
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including: http://en.pharmacodia.com/web/drug/1_8718.html

Sunepitron (CP-93,393) is an anxiolytic drug with highly selective serotonin 5-hydroxytryptamine 1A autoreceptor agonist, alpha2-adrenergic antagonist, and dopamine D2 agonist properties. Sunepitron hydrochloride had been in Phase III clinical trials by Pfizer for the treatment of anxiety disorder and depression. However, this research has been discontinued.

CNS Activity

Originator

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2849
Agonist
2752
 92.0 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Phase III
665
Unknown

Approved Use

Unknown
Primary
Withdrawn
Unknown

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1.02 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9571226/
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
10.92 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9571226/
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
2.36 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9571226/
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
87.33 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9571226/
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
0.9 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9571226/
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
4.1 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9571226/
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
5 mg single, oral
Dose: 5 mg
Route: oral
Route: single
Dose: 5 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/9571226/
healthy
Health Status: healthy
Sex: M
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/9571226/
Sources:
https://pubmed.ncbi.nlm.nih.gov/9571226/
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
substrate
1388

OverviewOther

Other InhibitorOther SubstrateOther Inducer
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
CYP2D6
1388
 major
Sourcing

Sourcing

Vendor/AggregatorIDURL
Axon MedChem
1519
https://www.axonmedchem.com/product/1519
BOC Sciences
148408-65-5
http://www.bocsci.com/description.asp?cas=148408-65-5
Compound Cloud
183092
Compound Cloud
6918176
eMolecules
110068823
https://orderbb.emolecules.com/search/#?query=110068823
eMolecules
271446115
https://orderbb.emolecules.com/search/#?query=271446115
eMolecules
301236505
https://orderbb.emolecules.com/search/#?query=301236505
eMolecules
301236761
https://orderbb.emolecules.com/search/#?query=301236761
eMolecules
50580280
https://orderbb.emolecules.com/search/#?query=50580280
mcule
MCULE-1128895085
https://mcule.com/MCULE-1128895085/
mcule
MCULE-2945972636
https://mcule.com/MCULE-2945972636/
MolPort
MolPort-042-665-705
https://www.molport.com/shop/molecule-link/MolPort-042-665-705
MuseChem
I009649
https://www.musechem.com/product/I009649.html
Tetrahedron
TS77820
http://www.thsci.com/search.do?q=TS77820
PubMed

PubMed

TitleDatePubMed
Psychopharmacology of depression in the next millennium.
1999-07
Assay and purity evaluation of sunepitron hydrochloride by reversed-phase liquid chromatography using a reference standard composite.
1998-11
Metabolism and excretion of a new anxiolytic drug candidate, CP-93, 393, in healthy male volunteers.
1998-05
Metabolism and excretion of a new antianxiety drug candidate, CP-93,393, in cynomolgus monkeys: identification of the novel pyrimidine ring cleaved metabolites.
1997-12
Patents

Patents

US5122525
2
US7678363
2

Sample Use Guides

In Vivo Use Guide
The excretion, biotransformation, and pharmacokinetics of Sunepitron (CP-93,393) were investigated in six healthy male volunteers after oral administration of a 5-mg dose of [14C]CP-93,393.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:01:01 GMT 2025
Edited
by admin
on Mon Mar 31 19:01:01 GMT 2025
Record UNII
1NYW5HLO1E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SUNEPITRON HYDROCHLORIDE
USAN  
USAN  
Official Name English
CP-93,393-1
Preferred Name English
N-((7S,9AS)-OCTAHYDRO-2-(2-PYRIMIDINYL)-2H-PYRIDO(1,2-A)PYRAZIN-7-YL)METHYL)SUCCINIMIDE MONOHYDROCHLORIDE
Common Name English
CP-93393-1
Code English
SUNEPITRON HYDROCHLORIDE [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47794
Created by admin on Mon Mar 31 19:01:01 GMT 2025 , Edited by admin on Mon Mar 31 19:01:01 GMT 2025
NCI_THESAURUS C29713
Created by admin on Mon Mar 31 19:01:01 GMT 2025 , Edited by admin on Mon Mar 31 19:01:01 GMT 2025
Code System Code Type Description
ChEMBL
CHEMBL2111058
Created by admin on Mon Mar 31 19:01:01 GMT 2025 , Edited by admin on Mon Mar 31 19:01:01 GMT 2025
PRIMARY
PUBCHEM
6918176
Created by admin on Mon Mar 31 19:01:01 GMT 2025 , Edited by admin on Mon Mar 31 19:01:01 GMT 2025
PRIMARY
EPA CompTox
DTXSID10869968
Created by admin on Mon Mar 31 19:01:01 GMT 2025 , Edited by admin on Mon Mar 31 19:01:01 GMT 2025
PRIMARY
FDA UNII
1NYW5HLO1E
Created by admin on Mon Mar 31 19:01:01 GMT 2025 , Edited by admin on Mon Mar 31 19:01:01 GMT 2025
PRIMARY
SMS_ID
300000055255
Created by admin on Mon Mar 31 19:01:01 GMT 2025 , Edited by admin on Mon Mar 31 19:01:01 GMT 2025
PRIMARY
NCI_THESAURUS
C152474
Created by admin on Mon Mar 31 19:01:01 GMT 2025 , Edited by admin on Mon Mar 31 19:01:01 GMT 2025
PRIMARY
CAS
148408-65-5
Created by admin on Mon Mar 31 19:01:01 GMT 2025 , Edited by admin on Mon Mar 31 19:01:01 GMT 2025
PRIMARY
USAN
FF-80
Created by admin on Mon Mar 31 19:01:01 GMT 2025 , Edited by admin on Mon Mar 31 19:01:01 GMT 2025
PRIMARY
Related Record Type Details
Structure of SUNEPITRON
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of SUNEPITRON
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