SODIUM ANTIMONYLGLUCONATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H8O7.Na.Sb
Molecular Weight	336.873
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Sb+3].OC[C@@H]([O-])[C@@H]([O-])[C@H]([O-])[C@@H](O)C([O-])=O

InChI

InChIKey=JEKOQEIHGHQVEI-ZBHRUSISSA-M

InChI=1S/C6H9O7.Na.Sb/c7-1-2(8)3(9)4(10)5(11)6(12)13;;/h2-5,7,11H,1H2,(H,12,13);;/q-3;+1;+3/p-1/t2-,3-,4+,5-;;/m1../s1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Sb
Molecular Weight	121.76
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H8O7
Molecular Weight	192.1235
Charge	-4
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14287627 | https://www.ncbi.nlm.nih.gov/pubmed/14128585 | https://www.ncbi.nlm.nih.gov/pubmed/14433281 | https://www.ncbi.nlm.nih.gov/pubmed/13187569

Sodium antimonylgluconate (triostam) is a trivalent antimony compound. It was used for the treatment of schistosomiasis. Usually given intravenously.

Approval Year

Targets

Primary Target	Pharmacology	Potency
Trypanothione reductase 5 Target ID: CHEMBL2176840 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7607216	Inhibitor 8504
Glutathione reductase 11 Target ID: CHEMBL2755 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7607216	Inhibitor 8504
ATP-dependent 6-phosphofructokinase 21 Target ID: Q27778 Gene ID: NA Gene Symbol: PFK Target Organism: Schistosoma mansoni (Blood fluke) Sources: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332489	Inhibitor 8504	200.0 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Leishmaniasis 20 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5302298 https://www.ncbi.nlm.nih.gov/pubmed/14287627 https://www.ncbi.nlm.nih.gov/pubmed/14287627	Curative		Approved 8583	TRIOSTAM Approved Use For the treatment of various types of a protozoal infection called leishmaniasis.

PubMed

Title	Date	PubMed
Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials.	1995-06-01	7607216
Comparative trials of antimonial drugs in urinary schistosomiasis.	1968	5302298
Stokes-Adams attacks following sodium antimonylgluconate (Triostam).	1966-11-19	5926116
THE INTENSIVE TREATMENT OF RECTAL SCHISTOSOMIASIS WITH TRIOSTAM (SODIUM ANTIMONYLGLUCONATE).	1965-01	14287627
USE OF "TRIOSTAM" (SODIUM ANTIMONYLGLUCONATE) AGAINST RECTAL SCHISTOSOMIASIS IN TANGANYIKA.	1964-03	14128585

Patents

Sample Use Guides

In Vivo Use Guide

The drug should be used at a total dosage not exceeding 25 mg. per kg. and a daily dosage not exceeding 6 mg. per kg.,

Route of Administration: Intravenous

In Vitro Use Guide

Both L. donovani trypanothione reductase and human erythrocyte glutathione reductase are inhibited by Sodium antimonylgluconate (5-100uM) in a timedependent manner.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:11:18 GMT 2025` Edited by `admin` on `Mon Mar 31 18:11:18 GMT 2025`
Record UNII	1U72RT57II
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM ANTIMONYLGLUCONATE

Common Name

English

ANTIMONY SODIUM GLUCONATE SODIUM ANTIMONYLGLUCONATE

Preferred Name

English

SODIUM SALT OF A TRIVALENT ANTIMONY DERIVATIVE OF GLUCONIC ACID

Common Name

English

SODIUM ANTIMONY GLUCONATE

Common Name

English

TRIOSTAM

Brand Name

English

ANTIMONY SODIUM GLUCONATE SODIUM ANTIMONYLGLUCONATE [MI]

Common Name

English

ANTIMONY SODIUM GLUCONATE (V)

Common Name

English

SODIUM ANTIMONY (III) GLUCONATE

Common Name

English

TRIOSTIB

Common Name

English

Code System Code Type Description

EVMPD

SUB127002