Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C10H19O7PS |
| Molecular Weight | 314.292 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)CC(SP(=O)(OC)OC)C(=O)OCC
InChI
InChIKey=WSORODGWGUUOBO-UHFFFAOYSA-N
InChI=1S/C10H19O7PS/c1-5-16-9(11)7-8(10(12)17-6-2)19-18(13,14-3)15-4/h8H,5-7H2,1-4H3
| Molecular Formula | C10H19O7PS |
| Molecular Weight | 314.292 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Malathion/oxon and lead acetate increase gene expression and protein levels of transient receptor potential canonical channel subunits TRPC1 and TRPC4 in rat endothelial cells of the blood-brain barrier. | 2012-06 |
|
| Polymorphism in the acetylcholinesterase gene of Musca domestica L. field populations in Turkey. | 2011-12 |
|
| In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases. | 2011-04-25 |
|
| Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. | 2011-03-28 |
|
| Esterase metabolism of cholinesterase inhibitors using rat liver in vitro. | 2011-03-15 |
|
| Assessments of tight junction proteins occludin, claudin 5 and scaffold proteins ZO1 and ZO2 in endothelial cells of the rat blood-brain barrier: cellular responses to neurotoxicants malathion and lead acetate. | 2011-01 |
|
| Down-regulated transcriptional level of Ace1 combined with mutations in Ace1 and Ace2 of Aphis gossypii are related with omethoate resistance. | 2010-12-05 |
|
| Activity levels of B-esterases in the tadpoles of 11 species of frogs in the middle Paraná River floodplain: implication for ecological risk assessment of soybean crops. | 2010-10 |
|
| [Rapid simultaneous determination of organophosphorus pesticides in human serum and urine by liquid chromatography-mass spectrometry]. | 2010-09 |
|
| In vitro reactivating effects of standard and newly developed oximes on malaoxon-inhibited mouse brain acetylcholinesterase. | 2010-09 |
|
| Baculovirus expression, biochemical characterization and organophosphate sensitivity of rBmAChE1, rBmAChE2, and rBmAChE3 of Rhipicephalus (Boophilus) microplus. | 2010-08-27 |
|
| Behavioral and morphological endpoints: as an early response to sublethal malathion intoxication in the freshwater fish, Labeo rohita. | 2010-04 |
|
| Heterogeneous ozonation of suspended malathion and chlorpyrifos particles. | 2010-04 |
|
| Comparison of two blood-brain barrier in vitro systems: cytotoxicity and transfer assessments of malathion/oxon and lead acetate. | 2010-04 |
|
| Investigation of in vitro effects of ethephon and chlorpyrifos, either alone or in combination, on rat intestinal muscle contraction. | 2010-03 |
|
| Evaluation of a modified QuEChERS method for the extraction of pesticides from agricultural, ornamental and forestal soils. | 2010-03 |
|
| Heterologous expression, purification, and biochemical characterization of a greenbug (Schizaphis graminum) acetylcholinesterase encoded by a paralogous gene (ace-1). | 2010-02-11 |
|
| Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection. | 2010-02-05 |
|
| Mass spectrometric analyses of organophosphate insecticide oxon protein adducts. | 2010-01 |
|
| Degradation behavior and products of malathion and chlorpyrifos spiked in apple juice by ultrasonic treatment. | 2010-01 |
|
| Selectivity of pesticides used in integrated apple production to the lacewing, Chrysoperla externa. | 2010 |
|
| Physiological and histopathological investigations on the effects of alpha-lipoic acid in rats exposed to malathion. | 2010 |
|
| The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status. | 2010 |
|
| Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiae. | 2009-09 |
|
| Cholinesterase based amperometric biosensors for assay of anticholinergic compounds. | 2009-06 |
|
| A study of the degradation of organophosphorus pesticides in river waters and the identification of their degradation products by chromatography coupled with mass spectrometry. | 2009-05 |
|
| Mechanisms of organophosphate resistance in a field population of oriental migratory locust, Locusta migratoria manilensis (Meyen). | 2009-05 |
|
| Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds. | 2009-04-15 |
|
| Increased organophosphate scavenging in a butyrylcholinesterase mutant. | 2008-09-25 |
|
| Mechanisms of resistance to malathion in the medfly Ceratitis capitata. | 2008-08 |
|
| Inhibition of AChE by malathion and some structurally similar compounds. | 2008-08 |
|
| Comparing the relative toxicity of malathion and malaoxon in blue catfish Ictalurus furcatus. | 2008-08 |
|
| Dermal absorption of a dilute aqueous solution of malathion. | 2008-07 |
|
| Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. | 2008-06 |
|
| Determination of low-level pesticide residues in soft drinks and sports drinks by liquid chromatography with tandem mass spectrometry: collaborative study. | 2008-04-02 |
|
| Inhibition of AChE by single and simultaneous exposure to malathion and its degradation products. | 2007-12 |
|
| Resistance to malathion in field populations of Ceratitis capitata. | 2007-12 |
|
| Assessment of attractiveness of plants as roosting sites for the melon fly, Bactrocera cucurbitae, and oriental fruit fly, Bactrocera dorsalis. | 2007 |
|
| Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice. | 2005-05 |
|
| Inhibition of carboxylesterases in SH-SY5Y human and NB41A3 mouse neuroblastoma cells by organophosphorus esters. | 1998-03-13 |
|
| Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. | 1997-07 |
|
| Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. | 1996 |
|
| Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. | 1994-06-21 |
|
| Malaoxon-induced brain phosphoinositide turnover and changes in brain calcium levels by female gender in pregnant and non-pregnant convulsing and non-convulsing rats. | 1993-11 |
|
| Malaoxon-induced neurotoxicity in old rats: alterations in cerebral inositol lipid signalling, brain tissue calcium levels and early neuronal injury. | 1993-04-30 |
|
| Potentiation of malaoxon-induced convulsions by lithium: early neuronal injury, phosphoinositide signaling, and calcium. | 1990-06-15 |
|
| Time-course of malaoxon-induced alterations in brain regional inositol-1-phosphate levels in convulsing and nonconvulsing rats. | 1989-02 |
|
| DDVP (dichlorvos) detoxification by binding and interactions with DDT, dieldrin, and malaoxon. | 1977-10 |
|
| Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases. | 1974-02 |
|
| Metabolism of organophosphorus insecticides. XIV. Malathion breakdown by soil fungi. | 1972-09 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:12:28 GMT 2025
by
admin
on
Mon Mar 31 22:12:28 GMT 2025
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| Record UNII |
2439JYF84Q
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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EPA PESTICIDE CODE |
657701
Created by
admin on Mon Mar 31 22:12:28 GMT 2025 , Edited by admin on Mon Mar 31 22:12:28 GMT 2025
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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1634-78-2
Created by
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2439JYF84Q
Created by
admin on Mon Mar 31 22:12:28 GMT 2025 , Edited by admin on Mon Mar 31 22:12:28 GMT 2025
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PRIMARY | |||
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Malaoxon
Created by
admin on Mon Mar 31 22:12:28 GMT 2025 , Edited by admin on Mon Mar 31 22:12:28 GMT 2025
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DTXSID9020790
Created by
admin on Mon Mar 31 22:12:28 GMT 2025 , Edited by admin on Mon Mar 31 22:12:28 GMT 2025
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15415
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admin on Mon Mar 31 22:12:28 GMT 2025 , Edited by admin on Mon Mar 31 22:12:28 GMT 2025
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4047
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2439JYF84Q
Created by
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6649
Created by
admin on Mon Mar 31 22:12:28 GMT 2025 , Edited by admin on Mon Mar 31 22:12:28 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|
