CERLAPIRDINE HYDROCHLORIDE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H23N3O3S.ClH
Molecular Weight	445.962
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN(C)CCCOC1=CC2=C(NN=C2S(=O)(=O)C3=CC=CC4=CC=CC=C34)C=C1

InChI

InChIKey=RNGAZJUESDPASQ-UHFFFAOYSA-N

InChI=1S/C22H23N3O3S.ClH/c1-25(2)13-6-14-28-17-11-12-20-19(15-17)22(24-23-20)29(26,27)21-10-5-8-16-7-3-4-9-18(16)21;/h3-5,7-12,15H,6,13-14H2,1-2H3,(H,23,24);1H

HIDE SMILES / InChI

Molecular Formula	C22H23N3O3S
Molecular Weight	409.501
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25217486 | https://www.ncbi.nlm.nih.gov/pubmed/24900216 | https://www.ncbi.nlm.nih.gov/pubmed/21330210 | https://www.ncbi.nlm.nih.gov/pubmed/22029285

Cerlapirdine is a selective and potent full antagonist of the serotonin 6 (5-HT6) receptor that has been investigated by Wyeth and Pfizer for the treatment of Alzheimer Disease.

Originator

Approval Year

PubMed

Title	Date	PubMed
Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.	2011-12-08	22029285
5-HT(6) receptor and cognition.	2011-02	21330210

Patents

Sample Use Guides

In Vivo Use Guide

5-mg/day

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:37:00 GMT 2025` Edited by `admin` on `Mon Mar 31 20:37:00 GMT 2025`
Record UNII	2VCB4037GE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CERLAPIRDINE HYDROCHLORIDE [USAN]

Preferred Name

English

CERLAPIRDINE HYDROCHLORIDE

Official Name

English

1-PROPANAMINE, N,N-DIMETHYL-3-((3-(1-NAPHTHALENYLSULFONYL)-1H-INDAZOL-5-YL)OXY)-, HYDROCHLORIDE (1:1)

Systematic Name

English

Cerlapirdine hydrochloride [WHO-DD]

Common Name

English

N,N-DIMETHYL-3-((3-(NAPHTHALEN-1-YLSULFONYL)-1H-INDAZOL-5-YL)OXY)PROPAN-1- AMINE MONOHYDROCHLORIDE

Systematic Name

English

SAM-531 HYDROCHLORIDE

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL2103880