U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 20:03:21 GMT 2025
Edited
by admin
on Tue Apr 01 20:03:21 GMT 2025
Protein Type RECEPTOR
Protein Sub Type NMDA|NMDA RECEPTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
43Q7J075IH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLUN2B
Preferred Name English
GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
Common Name English
N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT 3
Common Name English
GLUTAMATE (NMDA) RECEPTOR SUBUNIT EPSILON-2
Common Name English
HNR3
Common Name English
NR3
Common Name English
NMDAR2B
Common Name English
NR2B
Common Name English
N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2B
Common Name English
Code System Code Type Description
PHAROS
Q13224
Created by admin on Tue Apr 01 20:03:21 GMT 2025 , Edited by admin on Tue Apr 01 20:03:21 GMT 2025
PRIMARY
FDA UNII
43Q7J075IH
Created by admin on Tue Apr 01 20:03:21 GMT 2025 , Edited by admin on Tue Apr 01 20:03:21 GMT 2025
PRIMARY
WIKIPEDIA
GRIN2B
Created by admin on Tue Apr 01 20:03:21 GMT 2025 , Edited by admin on Tue Apr 01 20:03:21 GMT 2025
PRIMARY
UNIPROT
Q13224
Created by admin on Tue Apr 01 20:03:21 GMT 2025 , Edited by admin on Tue Apr 01 20:03:21 GMT 2025
PRIMARY
From To
1_60 1_295
1_403 1_430
1_410 1_431
1_720 1_775
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_48
N 1_315
N 1_322
N 1_418
N 1_465
N 1_516
N 1_662
Related Record Type Details
Structure of PEAQX
INHIBITOR -> TARGET
the Ki of PEAQX revealed it only shows a 5 fold difference in affinity for GluN1/GluN2A vs. GluN1/GluN2B receptors. It is also a potent anticonvulsant in animal tests.
COMPETITIVE ANTAGONIST
Structure of NP-10679
INHIBITOR -> TARGET
Potent and selective GluN2B subunit-specific NMDA (N-methyl-D-aspartate) receptor inhibitor.
Structure of RISLENEMDAZ
INHIBITOR -> TARGET
Structure of TAURINE
INHIBITOR -> TARGET
Structure of TRAXOPRODIL
INHIBITOR -> TARGET
Structure of PLAZINEMDOR
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Structure of WMS-1405
INHIBITOR -> TARGET
Ki
Structure of (2S)-4-[[5-(2-Fluoro-4-methylphenoxy)-2-pyrazinyl]methyl]-N-methyl-2-morpholinecarboxamide
INHIBITOR -> TARGET
Structure of Onfasprodil
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
ALLOSTERIC INHIBITOR
IC50
Structure of RADIPRODIL
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
Structure of WMS-1405 C-11
RADIOLIGAND->TARGET
Ki

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_856] [1_860] [1_891] [1_894] [1_1032] [1_1035] [1_1038] [1_1117] [1_1229] [1_1233] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966