Atazanavir Sulfate

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C38H52N6O7.H2O4S
Molecular Weight	802.934
Optical Activity	( - )
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OS(O)(=O)=O.COC(=O)N[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)[C@@H](O)CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C

InChI

InChIKey=DQSGVVGOPRWTKI-QVFAWCHISA-N

InChI=1S/C38H52N6O7.H2O4S/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28;1-5(2,3)4/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47);(H2,1,2,3,4)/t29-,30-,31+,32+;/m0./s1

HIDE SMILES / InChI

Molecular Formula	H2O4S
Molecular Weight	98.078
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C38H52N6O7
Molecular Weight	704.8555
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/21567_reyataz_lbl.pdf | https://www.ncbi.nlm.nih.gov/pubmed/15585441

Atazanavir is the first once-daily protease inhibitor for the treatment of human immunodeficiency virus type 1 infection and should be used only in combination therapy, as part of a highly active antiretroviral therapy (HAART) regimen. In addition to being the most potent protease inhibitor in vitro, atazanavir has a distinct cross-resistance profile that does not confer resistance to other protease inhibitors. However, resistance to other protease inhibitors often confers clinically relevant resistance to atazanavir.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Human immunodeficiency virus type 1 protease 36 Target ID: CHEMBL243 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18006837	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
HIV-1 infection 156 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/21567_reyataz_lbl.pdf	Curative		Approved 8583	REYATAZ Approved Use REYATAZ® (atazanavir sulfate) is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. This indication is based on analyses of plasma HIV-1 RNA levels and CD4+ cell counts from controlled studies of 96 weeks duration in antiretroviral-naive and 48 weeks duration in antiretroviral-treatment-experienced adult and pediatric patients at least 6 years of age. The following points should be considered when initiating therapy with REYATAZ: In Study AI424-045, REYATAZ/ritonavir and lopinavir/ritonavir were similar for the primary efficacy outcome measure of time-averaged difference in change from baseline in HIV RNA level. This study was not large enough to reach a definitive conclusion that REYATAZ/ritonavir and lopinavir/ritonavir are equivalent on the secondary efficacy outcome measure of proportions below the HIV RNA lower limit of detection [see Clinical Studies (14.2) Launch Date 2003

C_max

Value	Dose	Co-administered	Analyte	Population
5199 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	400 mg 1 times / day steady-state, oral dose: 400 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		ATAZANAVIR plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FED
2298 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	400 mg 1 times / day steady-state, oral dose: 400 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		ATAZANAVIR plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: FED
6129 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	300 mg 1 times / day steady-state, oral dose: 300 mg route of administration: Oral experiment type: STEADY-STATE co-administered: RITONAVIR	RITONAVIR	ATAZANAVIR plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FED
4422 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	300 mg 1 times / day steady-state, oral dose: 300 mg route of administration: Oral experiment type: STEADY-STATE co-administered: RITONAVIR	RITONAVIR	ATAZANAVIR plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: FED

AUC

Value	Dose	Co-administered	Analyte	Population
28132 ng × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	400 mg 1 times / day steady-state, oral dose: 400 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		ATAZANAVIR plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FED
14874 ng × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	400 mg 1 times / day steady-state, oral dose: 400 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		ATAZANAVIR plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: FED
57039 ng × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	300 mg 1 times / day steady-state, oral dose: 300 mg route of administration: Oral experiment type: STEADY-STATE co-administered: RITONAVIR	RITONAVIR	ATAZANAVIR plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FED
46073 ng × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	300 mg 1 times / day steady-state, oral dose: 300 mg route of administration: Oral experiment type: STEADY-STATE co-administered: RITONAVIR	RITONAVIR	ATAZANAVIR plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: FED

T_1/2

Value	Dose	Co-administered	Analyte	Population
7.9 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	400 mg 1 times / day steady-state, oral dose: 400 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		ATAZANAVIR plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FED
6.5 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	400 mg 1 times / day steady-state, oral dose: 400 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		ATAZANAVIR plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: FED
18.1 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	300 mg 1 times / day steady-state, oral dose: 300 mg route of administration: Oral experiment type: STEADY-STATE co-administered: RITONAVIR	RITONAVIR	ATAZANAVIR plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FED
8.6 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	300 mg 1 times / day steady-state, oral dose: 300 mg route of administration: Oral experiment type: STEADY-STATE co-administered: RITONAVIR	RITONAVIR	ATAZANAVIR plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: FED

F_unbound

Value	Dose	Co-administered	Analyte	Population
14% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf	400 mg 1 times / day steady-state, oral dose: 400 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		ATAZANAVIR plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FED

Doses

Dose	Population	Adverse events
30 g single, oral Overdose Dose: 30 g Route: oral Route: single Dose: 30 g Sources: https://pubmed.ncbi.nlm.nih.gov/29706057/	unhealthy, 40 years Health Status: unhealthy Age Group: 40 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/29706057/	Other AEs: Monomorphic ventricular tachycardia... Other AEs: Monomorphic ventricular tachycardia Sources: https://pubmed.ncbi.nlm.nih.gov/29706057/
400 mg 1 times / day steady, oral Recommended Dose: 400 mg, 1 times / day Route: oral Route: steady Dose: 400 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15156449/	unhealthy, adult Health Status: unhealthy Age Group: adult Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/15156449/	Disc. AE: Jaundice... Other AEs: Blood bilirubin indirect... AEs leading to discontinuation/dose reduction: Jaundice (7%) Other AEs: Blood bilirubin indirect (33%) Sources: https://pubmed.ncbi.nlm.nih.gov/15156449/

AEs

AE	Significance	Dose	Population
Monomorphic ventricular tachycardia		30 g single, oral Overdose Dose: 30 g Route: oral Route: single Dose: 30 g Sources: https://pubmed.ncbi.nlm.nih.gov/29706057/	unhealthy, 40 years Health Status: unhealthy Age Group: 40 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/29706057/
Blood bilirubin indirect	33%	400 mg 1 times / day steady, oral Recommended Dose: 400 mg, 1 times / day Route: oral Route: steady Dose: 400 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15156449/	unhealthy, adult Health Status: unhealthy Age Group: adult Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/15156449/
Jaundice	7% Disc. AE	400 mg 1 times / day steady, oral Recommended Dose: 400 mg, 1 times / day Route: oral Route: steady Dose: 400 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15156449/	unhealthy, adult Health Status: unhealthy Age Group: adult Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/15156449/

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1946	substrate 1193 inhibitor 2438	substrate 1388 inhibitor 2507	inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 2153 CYP2A6 879 CYP2C19 2057 CYP2E1 1060 CYP3A4/5 296 CYP4A9/11 35 UGT1A1 246 P-gp 1741 OATP1B1 1079 OATP1B3 961 BCRP 910	CYP1A2 1197 CYP2A6 626 CYP2B6 776 CYP2E1 729 CYP2C19 1119 P-gp 2052

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
CYP2A6 911	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28.0	no
CYP2C19 2141	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28.0	no
CYP2D6 2546	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28.0	no
CYP2E1 1146	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28.0	no
CYP4A9/11 35	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28.0	no
P-gp 1932	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28.0	weak [IC50 29 uM]
OATP1B1 1095	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/20102298/	yes [IC50 1.7 uM]
OATP1B3 970	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/20102298/	yes [IC50 3 uM]
CYP2C19 2141	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28.0	yes [IC50 4.9 uM]	BMS-551160 2
BCRP 985	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/20102298/	yes [IC50 69.1 uM]
CYP1A2 2333	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28.0	yes [Ki 12.1 uM]
CYP2C9 2497	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28.0	yes [Ki 12.7 uM]
CYP3A4/5 357	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28,32	yes [Ki 2.35 uM]		yes (co-administration study) Comment: competitive and mechanism-based inhibition; administration with clarithromycin increased clarithromycin AUC by 94% and reduced 14-OH clarithromycin by 70; atazanavir increased diltiazem concentration by ~100%; Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28,32
UGT1A1 303	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28.0	yes

Drug as victim

Target	Modality	Activity	Clinical evidence
P-gp 2052	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=28 Page: 28.0	likely
CYP1A2 1197	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=27 Page: 27.0	not significant
CYP2A6 626	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=27 Page: 27.0	not significant
CYP2B6 776	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=27 Page: 27.0	not significant
CYP2C19 1119	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=27 Page: 27.0	not significant
CYP2C9 1193	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=27 Page: 27.0	not significant
CYP2D6 1388	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=27 Page: 27.0	not significant
CYP2E1 729	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=27 Page: 27.0	not significant
CYP3A4 1946	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=27 Page: 27,29	yes	yes (co-administration study) Comment: 100% and 71% inhibition of ketonconazole and troleandomycin, respectively; administration with ritonavir increased atazanavir Cmax, AUC, and Cmin by 17%, 103%, and 671%, respectively; Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_BioPharmr_P1.pdf#page=27 Page: 27,29

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-567_Reyataz_Pharmr_P1A.pdf#page=7 Page: 7.0

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:37924	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:37924
eMolecules	32176608	https://www.emolecules.com/cgi-bin/more?vid=32176608
MolPort	MolPort-003-986-575	https://www.molport.com/shop/molecule-link/MolPort-003-986-575
ZINC	ZINC000003941496	http://zinc15.docking.org/substances/ZINC000003941496

PubMed

Title	Date	PubMed
Determination of the new HIV-protease inhibitor atazanavir by liquid chromatography after solid-phase extraction.	2004-10-15	15358304
Atazanavir.	2004-10	15353575
Pseudoaneurysm of the femoral artery in a HIV-infected man.	2004-10	15350573
Gateways to clinical trials.	2004-09-07	15349141
HIV-chemotherapy and -prophylaxis: new drugs, leads and approaches.	2004-09	15183346
Comparison of once-daily atazanavir with efavirenz, each in combination with fixed-dose zidovudine and lamivudine, as initial therapy for patients infected with HIV.	2004-08-15	15247553
Resistance to HIV protease inhibitors: mechanisms and clinical consequences.	2004-08	15320704
Acute hepatic cytolysis in an HIV-infected patient taking atazanavir.	2004-07-23	15238786
Atazanavir: a new protease inhibitor to treat HIV infection.	2004-07-01	15287232
Atazanavir enhances saquinavir hard-gel concentrations in a ritonavir-boosted once-daily regimen.	2004-06-18	15362661
Long-term efficacy and safety of atazanavir with stavudine and lamivudine in patients previously treated with nelfinavir or atazanavir.	2004-06-01	15167287
Atazanavir: new option for treatment of HIV infection.	2004-06-01	15156449
The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients.	2004-06	15259893
Antiviral drugs in current clinical use.	2004-06	15125867
Simultaneous quantification of the new HIV protease inhibitors atazanavir and tipranavir in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.	2004-05-25	15081931
Identification of I50L as the signature atazanavir (ATV)-resistance mutation in treatment-naive HIV-1-infected patients receiving ATV-containing regimens.	2004-05-15	15122516
[New treatment options for HIV-infected patients].	2004-05-07	15174468
Boosted Reyataz: 48-week results.	2004-05-04	15119279
Gateways to clinical trials.	2004-05	15319808
Does atazanavir cause lipodystrophy?	2004-05	15238875
Initial therapy for human immunodeficiency virus: broadening the options.	2004-04-30	15116286
[Atazanavir protects lipid metabolism. New PI with favorable metabolic profile].	2004-04-26	15373065
[Good experiences with saquinavir. Double boosting of protease inhibitors gains significance].	2004-04-26	15373047
[Interview with Professor Jürgen Rockstroh, director of the Bonn University Clinic. Atazanavir in general practice].	2004-04-26	15373037
[Long-term tolerance. Favorable lipid profile--favorable effect on development of lipodystrophy?].	2004-04-26	15373036
[Simplified HIV therapy. Atazanavir: the first protease inhibitor with once daily administration].	2004-04-26	15373035
New drugs of 2003.	2004-04-22	15098851
Regression of lipodystrophy in HIV-infected patients under therapy with the new protease inhibitor atazanavir.	2004-04-09	15060446
Cross-resistance patterns among HIV protease inhibitors.	2004-04	15142350
Atazanavir (Reyataz): new recommendations if combined with tenofovir (Viread) -- and warning on Viagra, Cialis, and Levitra.	2004-03-26	15199867
Kinetic and thermodynamic characterization of HIV-1 protease inhibitors.	2004-03-18	15027031
Optimizing dosing strategies for the combination of atazanavir plus saquinavir.	2004-03-05	15090782
Drug-induced liver injury associated with antiretroviral therapy that includes HIV-1 protease inhibitors.	2004-03-01	14986280
Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics.	2004	15217303
Peptidomimetic inhibitors of HIV protease.	2004	15193140
Three new drugs approved by FDA.	2003-12-31	14696579
[Are all boosted protease inhibitors the same? Previously treated patients profit too from lopinavir/r].	2003-12-11	14963981
Pharmacokinetics of amprenavir given once or twice a day when combined with atazanavir in heavily pre-treated HIV-positive patients.	2003-12-05	14685066
Dose-ranging, randomized, clinical trial of atazanavir with lamivudine and stavudine in antiretroviral-naive subjects: 48-week results.	2003-12-05	14685054
The continuing evolution of HIV therapy.	2003-12	14959692
Gateways to clinical trials.	2003-12	14735233
New anti-HIV protease inhibitors provide more treatment options.	2003-11	14746663
Atazanavir sulphate.	2003-11	14702957
Atazanavir (Reyataz).	2003-10	14696568
FDA notifications. Reyataz is approved for HIV treatment.	2003-09	14686309
Drug profile: atazanavir (Reyataz, ATV).	2003-07	14696562
Atazanavir: clinical use.	2003-07	14696561
["Once daily" drugs simplify therapy. Rp. HAART once daily].	2003-04-28	15011606
[Highly effective drug without modifying the lipid profile. Atazanavir, the protease inhibitor for "once daily" administration].	2003-04-28	15011577
[Antiretroviral therapy 2003. The current status].	2003-04-28	15011574

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose of REYATAZ ((atazanavir sulfate) capsules) is 400 mg (two 200-mg capsules) once daily taken with food. When coadministered with efavirenz, it is recommended that REYATAZ 300 mg and ritonavir 100 mg be given with efavirenz 600 mg (all as a single daily dose with food). REYATAZ without ritonavir should not be coadministered with efavirenz. When coadministered with didanosine buffered formulations, 589 REYATAZ should be given (with food) 2 hours before or 1 hour after didanosine.

Route of Administration: Oral

In Vitro Use Guide

It was investigated the effect of atazanavir on P-glycoprotein (P-gp) expression and activity, as well as its inhibitory potency against CYP3A activity. Induction of P-gp activity and expression was studied using LS180V cells. P-gp inhibition was studied using both LS180V cells and Caco-2 cells. Extended (3-day) exposure of LS180V cells to 30 microM atazanavir caused a 2.5-fold increase in immunoreactive P-gp expression as well as a concentration-dependent decrease of intracellular Rh123 to a mean 45% (S.D. 5.2%) of control. Acute exposure (2 h) of LS180V cells to atazanavir increased intracellular Rh123 concentrations up to 300% of control at 100 microM atazanavir. At 30 microM and above, acute atazanavir exposure reversed P-gp induction caused by 3-day pretreatment with 10 microM ritonavir. P-gp inhibition was also observed in Caco-2 cells, causing an effect comparable to that observed for the known P-gp inhibitor verapamil (50% of control). In HLM, atazanavir was an inhibitor of triazolam hydroxylation, with inhibitory potency greatly increased by preincubation. IC50 values with and without preincubation were 0.31 microM (S.D. 0.13) and 5.7 microM (S.D. 4.1), respectively.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:11:20 GMT 2025` Edited by `admin` on `Mon Mar 31 18:11:20 GMT 2025`
Record UNII	4MT4VIE29P
Record Status	`Validated (UNII)`
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Name

Type

Language

Atazanavir Sulfate

Official Name

English

ATAZANAVIR SULPHATE

Preferred Name

English

EVOTAZ COMPONENT ATAZANAVIR SULFATE

Brand Name

English

Atazanavir Sulfate [USP MONOGRAPH]

Common Name

English

Methyl [(5S,10S,11S,14S)-11-benzyl-5-tert-butyl-10-hydroxy-15,15-dimethyl-3,6,13-trioxo-8-[[4-(pyridin-2-yl)phenyl]methyl]-2-oxa-4,7,8,12-tetraazahexadecan-14-yl]carbamate sulfate

Systematic Name

English

ATAZANAVIRI SULFAS [WHO-IP LATIN]

Common Name

English

2,5,6,10,13-Pentaazatetradecanedioic acid, 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-, dimethyl ester, (3S,8S,9S,12S)-, sulfate (1:1) (salt)

Systematic Name

English

ATAZANAVIR SULFATE [MI]

Common Name

English

Dimethyl (3S,8S,9S,12S)-9-benzyl-3,12,di-tert-butyl-8-hydroxy-4,11-dioxo-6-(p-2-pyridylbenzyl)-2,5,6,10,13-pentaazatetradecanedioate, sulfate (1:1) (salt)

Systematic Name

English

REYATAZ

Brand Name

English

ATAZANAVIR SULFATE [WHO-IP]

Common Name

English

ATAZANAVIR SO4 [VANDF]

Common Name

English

ATAZANAVIR SULFATE [EP MONOGRAPH]

Common Name

English

ATAZANAVIR SULFATE [ORANGE BOOK]

Common Name

English

Atazanavir sulfate [WHO-DD]

Common Name

English

NSC-742546

Code

English

ATAZANAVIR SO4

Common Name

English

ATAZOR

Common Name

English

2,5,6,10,13-Pentaazatetradecanedioic acid, 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-, 1,14-dimethyl ester, (3S,8S,9S,12S)-, sulfate (1:1)

Systematic Name

English

ATAZANAVIR SULFATE [USP-RS]

Common Name

English

ATAZANAVIR SULFATE [USAN]

Common Name

English

BMS-232632-05

Code

English

ATAZANAVIR SULPHATE [EMA EPAR]

Common Name

English

ATAZANAVIR SULFATE [MART.]

Common Name

English

ATAZANAVIR SULFATE [JAN]

Common Name

English

Classification Tree Code System Code

EMA ASSESSMENT REPORTS

EVOTAZ (AUTHORIZED: HIV INFECTIONS)