ST-1936

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H17ClN2
Molecular Weight	236.74
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCC1=C(C)NC2=C1C=C(Cl)C=C2

InChI

InChIKey=KSYMELKKLOFABL-UHFFFAOYSA-N

InChI=1S/C13H17ClN2/c1-9-11(6-7-16(2)3)12-8-10(14)4-5-13(12)15-9/h4-5,8,15H,6-7H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C13H17ClN2
Molecular Weight	236.74
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21549693 | https://www.ncbi.nlm.nih.gov/pubmed/21645553

ST1936 is a potent serotonin 6 (5-HT6) receptor agonist with activity in animal pharmacological models for central nervous system disorders: effect of ST 1936 was investigated on depression-like experimental models. In addition, ST 1936 displays moderate affinity for human α2 adrenergic receptors, shown to increase Ca2+ concentration and phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 in cloned cells.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 6 (5-HT6) receptor 44 Target ID: CHEMBL3371 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21549693	Agonist 2752		28.8 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Depression 240 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21645553	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors.	2011-07-01	21549693
A microdialysis study of ST1936, a novel 5-HT6 receptor agonist.	2011-03	21185318
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.	2005-10-01	16055331

Patents

Sample Use Guides

In Vivo Use Guide

in rats: It was investigated the effect of ST1936 (5-10-20 mg/kg/ip) on dialysate DA, NA and 5-HT in the medial prefrontal cortex (PFCX) and in the shell and core of the nucleus accumbens (NAc). Systemic administration of ST1936 dose-dependently increased dialysate DA and NA in the NAc shell and PFCX and to a lesser extent in the NAc core.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:54:33 GMT 2025` Edited by `admin` on `Wed Apr 02 09:54:33 GMT 2025`
Record UNII	4R5ZNV2CHC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1H-INDOLE-3-ETHANAMINE, 5-CHLORO-N,N,2-TRIMETHYL-

Preferred Name

English

ST-1936

Code

English

5-CHLORO-N,N,2-TRIMETHYL-1H-INDOLE-3-ETHANAMINE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID001045649