METHYLDOPA

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C10H13NO4.3H2O
Molecular Weight	476.4749
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of METHYLDOPA

Structure Search

SMILES

O.O.O.C[C@](N)(CC1=CC(O)=C(O)C=C1)C(O)=O.C[C@](N)(CC2=CC(O)=C(O)C=C2)C(O)=O

InChI

InChIKey=YKFCISHFRZHKHY-NGQGLHOPSA-N

InChI=1S/2C10H13NO4.3H2O/c2*1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6;;;/h2*2-4,12-13H,5,11H2,1H3,(H,14,15);3*1H2/t2*10-;;;/m00.../s1

HIDE SMILES / InChI

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C10H13NO4
Molecular Weight	211.2145
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:13:13 UTC 2023` Edited by `admin` on `Fri Dec 15 15:13:13 UTC 2023`
Record UNII	56LH93261Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METHYLDOPA

Official Name

English

NSC-760080

Code

English

ALDORIL COMPONENT METHYLDOPA

Common Name

English

L-3-(3,4-DIHYDROXYPHENYL)-2-METHYLALANINE SESQUIHYDRATE

Common Name

English

ALPHA-METHYLDOPA

Common Name

English

DOPEGYT

Brand Name

English

METHYLDOPUM [WHO-IP LATIN]

Common Name

English

L-TYROSINE, 3-HYDROXY-.ALPHA.-METHYL-, SESQUIHYDRATE

Common Name

English

L-TYROSINE, 3-HYDROXY-.ALPHA.-METHYL-, HYDRATE (2:3)

Systematic Name

English

Methyldopa sesquihydrate [WHO-DD]

Common Name

English

PRESINOL

Brand Name

English

METHYLDOPA [USAN]

Common Name

English

METHYLDOPA [USP-RS]

Common Name

English

METHYLDOPA [USP MONOGRAPH]

Common Name

English

METHYLDOPA [ORANGE BOOK]

Common Name

English

METHYLDOPA [VANDF]

Common Name

English

MK-351

Code

English

METHYLDOPA SESQUIHYDRATE [MI]

Common Name

English

METHYLDOPA SESQUIHYDRATE

Common Name

English

DOPAMET

Brand Name

English

METHYLDOPA SESQUIHYDRATE [MART.]

Common Name

English

METHYLDOPA [WHO-IP]

Common Name

English

METHYLDOPA HYDRATE

Systematic Name

English

METHYLDOPA COMPONENT OF ALDORIL

Common Name

English

METHYLDOPA [MART.]

Common Name

English

MEDOPREN

Brand Name

English

METHYLDOPA [EP MONOGRAPH]

Common Name

English

ALDOMET

Brand Name

English

METHYLDOPA HYDRATE [JAN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QC02AB01

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

LIVERTOX

NBK548173

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

NCI_THESAURUS

C270

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

FDA ORPHAN DRUG

548616

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

WHO-VATC

QC02LB01

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

NCI_THESAURUS

C66884

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

NDF-RT

N0000175554

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

12.3

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

Code System Code Type Description

DRUG CENTRAL

1762

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

NSC

760080

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

EVMPD

SUB08867MIG

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

CHEBI

61058

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

EPA CompTox

DTXSID5020863

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

DRUG BANK

DB00968

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

DAILYMED

56LH93261Y

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

PUBCHEM

38852

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

LACTMED

Methyldopa

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

RS_ITEM_NUM

1426002

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

ChEMBL

CHEMBL459

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

FDA UNII

56LH93261Y

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

NCI_THESAURUS

C47616

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

RXCUI

6876

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

RxNorm

MESH

D008750

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

MERCK INDEX

m7397

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

CAS

41372-08-1

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

WHO INTERNATIONAL PHARMACOPEIA

METHYLDOPA

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

Description: White to yellowish white, fine powder or lumps; odourless. Solubility: Slightly soluble in water and ethanol (~750 g/l) TS; practically insoluble in ether R. Category: Antihypertensive. Storage: Methyldopa should be kept in a well-closed container, protected from light. Definition: Methyldopa contains not less than 98.0% and not more than 101.0% of C10H13NO4, calculated with reference to the anhydrous substance.

EVMPD

SUB25993

Created by admin on Fri Dec 15 15:13:13 UTC 2023 , Edited by admin on Fri Dec 15 15:13:13 UTC 2023

PRIMARY

Related Record Type Details


					M4R0H12F6M

METHYLDOPA ANHYDROUS

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (TITRATION)

Qualification:

USP

Amount:


					M4R0H12F6M

METHYLDOPA ANHYDROUS

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (TITRATION)

Qualification:

EP

Amount:


					M4R0H12F6M

METHYLDOPA ANHYDROUS

ANHYDROUS->SOLVATE


					M4R0H12F6M

METHYLDOPA ANHYDROUS

PARENT -> SALT/SOLVATE

Related Record Type Details


					87SI2AOH39

3-O-METHYLMETHYLDOPA

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					X099OP8549

3-METHOXY-O,.ALPHA.-DIMETHYL-L-TYROSINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					X099OP8549

3-METHOXY-O,.ALPHA.-DIMETHYL-L-TYROSINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					87SI2AOH39

3-O-METHYLMETHYLDOPA

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					8K91SZC8W9

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					N51CEY7JMT

O,.ALPHA.-DIMETHYL-L-TYROSINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					N51CEY7JMT

O,.ALPHA.-DIMETHYL-L-TYROSINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

Related Record Type Details


					M4R0H12F6M

METHYLDOPA ANHYDROUS

ACTIVE MOIETY