NAPACTADINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H16N2
Molecular Weight	212.2902
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN\C(CC1=CC=C2C=CC=CC2=C1)=N/C

InChI

InChIKey=NAHCWQNNENHGNH-UHFFFAOYSA-N

InChI=1S/C14H16N2/c1-15-14(16-2)10-11-7-8-12-5-3-4-6-13(12)9-11/h3-9H,10H2,1-2H3,(H,15,16)

HIDE SMILES / InChI

Molecular Formula	C14H16N2
Molecular Weight	212.2902
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4067998 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf?sequence=1&isAllowed=y

Napactadine is a bicyclic antidepressant agent. It is a histamine-H1 receptor antagonist. Preliminary results indicated a marked improvement in depressive symptomalology within 7 days of treatment, as measured by the Hamilton depression scale. However, clinical studies were discontinued after chronic administration of napactadine because an elevation in liver enzyme levels was observed in some patients.

Approval Year

PubMed

Title	Date	PubMed
New bicyclic antidepressant agent. Synthesis and activity of napactadine and related compounds.	1985-11	4067998

Substance Class	Chemical Created by `admin` on `Wed Apr 02 07:37:07 GMT 2025` Edited by `admin` on `Wed Apr 02 07:37:07 GMT 2025`
Record UNII	571S87U90N
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NAPACTADINE

Official Name

English

napactadine [INN]

Preferred Name

English

2-NAPHTHALENEETHANIMIDAMIDE, N,N'-DIMETHYL-

Systematic Name

English

N,N'-DIMETHYL-2-NAPHTHALENEACETAMIDINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578