PARATHION

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H14NO5PS
Molecular Weight	291.261
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+]([O-])=O

InChI

InChIKey=LCCNCVORNKJIRZ-UHFFFAOYSA-N

InChI=1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C10H14NO5PS
Molecular Weight	291.261
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes.	2015-10-01	26196221
Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum.	2015-09	26215119
Pesticide exposure and depression among male private pesticide applicators in the agricultural health study.	2014-09	24906048
Pesticide use and incident diabetes among wives of farmers in the Agricultural Health Study.	2014-09	24727735
Comparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression.	2014-01	24291005
Comparative effects of parathion and chlorpyrifos on extracellular endocannabinoid levels in rat hippocampus: influence on cholinergic toxicity.	2013-11-01	23933531
Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study.	2013-10	24064777
Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer.	2013-09	23833127
Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.	2013-06	22954530
Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs.	2013-04-15	23377347
Chlorpyrifos-, diisopropylphosphorofluoridate-, and parathion-induced behavioral and oxidative stress effects: are they mediated by analogous mechanisms of action?	2013-01	22986948
Role of regulatory T cells in the induction of atopic dermatitis by immunosuppressive chemicals.	2012-09-18	22842586
Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity.	2012-08-16	22562034
DNA methylation alterations in response to pesticide exposure in vitro.	2012-08	22847954
Immunotoxicity in mice induced by short-term exposure to methoxychlor, parathion, or piperonyl butoxide.	2012-07-28	22834942
Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran.	2012-02-05	22209767
Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk.	2012-02	22102698
Prior or coinstantaneous oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction in NC/Nga mice.	2011-11-18	21864637
Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons.	2011-09-01	21767560
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.	2011-03-28	21251949
Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays.	2011-02-27	21115097
Prior exposure to organophosphorus and organochlorine pesticides increases the allergic potential of environmental chemical allergens in a local lymph node assay.	2010-12-15	20920556
Constitutive androstane receptor -null mice are sensitive to the toxic effects of parathion: association with reduced cytochrome p450-mediated parathion metabolism [corrected].	2010-09	20573718
Evidence that adaptation in Drosophila is not limited by mutation at single sites.	2010-06-17	20585551
A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay.	2010-06-01	20206647
Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study.	2010-06	20164001
Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion.	2010-02	20123610
Blood gene expression markers to detect and distinguish target organ toxicity.	2010-02	19784758
Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study.	2009-12	19541724
Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes.	2009-11	19787260
Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions.	2009-06	19590683
Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides.	2009-03-15	19146868
A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures.	2009-01	18832183
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.	2008-09-25	18617161
Gas-phase mechanisms of degradation of hazardous organophosphorus compounds: do they follow a common pattern of alkaline hydrolysis reaction as in phosphotriesterase?	2008-08-14	18630959
OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides.	2008-05-21	18378376
Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification.	2008-04-01	18164358
Cancer genes induced by malathion and parathion in the presence of estrogen in breast cells.	2008-02	18204794
Sorption of hydrophobic organic compounds (HOC) in rapeseed oil bodies.	2008-02	17942138
Evaluation of androgen receptor transcriptional activities of some pesticides in vitro.	2008-01-14	17980950
Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study.	2008-01-01	17932376
Human drug metabolism genes in parathion-and estrogen-treated breast cells.	2007-12	17982697
Gene and protein expressions induced by 17beta-estradiol and parathion in cultured breast epithelial cells.	2006-10-12	17622325
Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein.	1996-11	8917702
The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice.	1983-04	6857660
Changes in toxicity of DDVP, DFP, and parathion in rats under cold environment.	1982-11	7150809
Effect of phenobarbitol pretreatment on regeneration of plasma cholinesterase activity inhibited by parathion or dichlorovos.	1982-01-01	7059232
Pathways of microbial metabolism of parathion.	1976-01	8005
Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases.	1974-02	4859365
Suxamethonium sensitivity.	1971-07-06	4998912

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:51:22 GMT 2025` Edited by `admin` on `Mon Mar 31 17:51:22 GMT 2025`
Record UNII	61G466064D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

E-605

Preferred Name

English

PARATHION

Common Name

English

PARATHION [MI]

Common Name

English

PARATHION [IARC]

Common Name

English

NSC-8933

Code

English

O,O-DIETHYL O-4-NITROPHENYL PHOSPHOROTHIOATE

Systematic Name

English

Parathion [WHO-DD]

Common Name

English

DIETHYL-P-NITROPHENYL MONOTHIOPHOSPHATE

Common Name

English

PARATHION [MART.]

Common Name

English

THIOPHOS

Common Name

English

PARATHION [ISO]

Common Name

English

O,O-DIETHYL O-(4-NITROPHENYL) PHOSPHOROTHIOATE

Systematic Name

English

PARATHION [HSDB]

Common Name

English

PHOSPHOROTHIOIC ACID O,O-DIETHYL O-(4-NITROPHENYL) ESTER

Systematic Name

English

Classification Tree Code System Code

IARC

Parathion

EPA PESTICIDE CODE

57501