Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H8N2O2 |
| Molecular Weight | 152.1506 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C=C(C=CC1=O)C(N)=O
InChI
InChIKey=JLQSXXWTCJPCBC-UHFFFAOYSA-N
InChI=1S/C7H8N2O2/c1-9-4-5(7(8)11)2-3-6(9)10/h2-4H,1H3,(H2,8,11)
| Molecular Formula | C7H8N2O2 |
| Molecular Weight | 152.1506 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. | 2010-10 |
|
| Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. | 2010-05 |
|
| Simultaneous determination of nicotinic acid and its four metabolites in rat plasma using high performance liquid chromatography with tandem mass spectrometric detection (LC/MS/MS). | 2010-04-01 |
|
| Two new megastigmane sulphonoglucosides from Mallotus anisopodus. | 2009-07 |
|
| Are so-called uremic toxins always toxic? | 2008-01 |
|
| 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. | 2007-07-10 |
|
| Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites. | 2007-06 |
|
| Relationship between uremic toxins and oxidative stress in patients with chronic renal failure. | 2007 |
|
| Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure. | 2006-06 |
|
| Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH. | 2006-04 |
|
| Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats. | 2006-02 |
|
| The novel nucleotide 4KNTP, in high concentrations in erythrocytes of renal failure children: a comparison with accumulation of other putative precursors in the plasma. | 2006 |
|
| Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status. | 2005-03-25 |
|
| The effect of N-methyl-2-pyridone-5-carboxamide--A nicotinamide catabolite on poly ADP-rybosylation and oxidative stress injury in endothelial cells. | 2005 |
|
| Conversion ratio of tryptophan to niacin in Japanese women fed a purified diet conforming to the Japanese Dietary Reference Intakes. | 2004-12 |
|
| An unusual pyridine nucleotide accumulating in erythrocytes: its identity and positive correlation with degree of renal failure. | 2004-10 |
|
| Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure. | 2003-09 |
|
| N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin? | 2003-05 |
|
| Increase in conversion of tryptophan to niacin in pregnant rats. | 2003 |
|
| Identification of N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-5-carboxamide as components in urine extracts of individuals consuming coffee. | 2002-10-15 |
|
| Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats. | 2002-06 |
|
| Accumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure. | 2002-02 |
|
| [Effect of feeding with a poisonous mushroom Clitocybe acromelalga on the metabolism of tryptophan-niacin in rats]. | 2001-06 |
|
| The metabolism of nicotinamide in human liver cirrhosis: a study on N-methylnicotinamide and 2-pyridone-5-carboxamide production. | 2001-04 |
|
| Quantitation of urinary niacin metabolites by reversed-phase liquid chromatography. | 1982-11 |
|
| Excretion of tryptophan-niacin metabolites by young men: effects of tryptophan, leucine, and vitamin B6 intakes. | 1980-10 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:24:59 GMT 2025
by
admin
on
Mon Mar 31 22:24:59 GMT 2025
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| Record UNII |
68139USC7W
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID70220374
Created by
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68139USC7W
Created by
admin on Mon Mar 31 22:24:59 GMT 2025 , Edited by admin on Mon Mar 31 22:24:59 GMT 2025
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N1-Methyl-2-pyridone-5-carboxamide
Created by
admin on Mon Mar 31 22:24:59 GMT 2025 , Edited by admin on Mon Mar 31 22:24:59 GMT 2025
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27410
Created by
admin on Mon Mar 31 22:24:59 GMT 2025 , Edited by admin on Mon Mar 31 22:24:59 GMT 2025
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701-44-0
Created by
admin on Mon Mar 31 22:24:59 GMT 2025 , Edited by admin on Mon Mar 31 22:24:59 GMT 2025
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69698
Created by
admin on Mon Mar 31 22:24:59 GMT 2025 , Edited by admin on Mon Mar 31 22:24:59 GMT 2025
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| Related Record | Type | Details | ||
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PARENT -> METABOLITE | |||
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PARENT -> METABOLITE |
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