BGC-20-1259 fumarate

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C19H23N3O5.C4H4O4
Molecular Weight	862.8782
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C\C(O)=O.CN[C@@H](CCOC1=CC=C(C=C1)[N+]([O-])=O)C2=CC=C(OC(=O)N(C)C)C=C2.CN[C@@H](CCOC3=CC=C(C=C3)[N+]([O-])=O)C4=CC=C(OC(=O)N(C)C)C=C4

InChI

InChIKey=JOSUCKKYZJUIPW-SOBORHNCSA-N

InChI=1S/2C19H23N3O5.C4H4O4/c2*1-20-18(12-13-26-16-10-6-15(7-11-16)22(24)25)14-4-8-17(9-5-14)27-19(23)21(2)3;5-3(6)1-2-4(7)8/h2*4-11,18,20H,12-13H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*18-;/m00./s1

HIDE SMILES / InChI

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	C19H23N3O5
Molecular Weight	373.403
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Tue Apr 01 16:59:03 GMT 2025` Edited by `admin` on `Tue Apr 01 16:59:03 GMT 2025`
Record UNII	6WJ4EP5PJ5
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BGC 20-1259 fumarate

Preferred Name

English

BGC-20-1259 fumarate

Code

English

RS 1259

Code

English

(E)-BUT-2-ENEDIOIC ACID; (4-((1S)-1-(METHYLAMINO)-3-(4-NITROPHENOXY)PROPYL)PHENYL) N,N-DIMETHYLCARBAMATE

Systematic Name

English

2.4-((1S)-METHYLAMINO-3-(4-NITROPHENOXY)PROPYLPHENYL N,N-DIMETHYLCARBAMATE (FUMARIC ACID)(1-2)SALT)

Systematic Name

English

(4-((3S)-3-(4-(DIMETHYLCARBAMOYLOXY)PHENYL)-3-(METHYLAMINO)PROPOXY)PHENYL)AZINIC ACID FUMARIC ACID

Systematic Name

English

RS-1259

Code

English

Code System Code Type Description

MANUFACTURER PRODUCT INFORMATION

(4-((3S)-3-(4-(DIMETHYLCARBAMOYLOXY)PHENYL)-3-(METHYLAMINO)PROPOXY)PHENYL)AZINIC ACID FUMARIC ACID

Created by admin on Tue Apr 01 16:59:03 GMT 2025 , Edited by admin on Tue Apr 01 16:59:03 GMT 2025

PRIMARY

FDA UNII

6WJ4EP5PJ5

Created by admin on Tue Apr 01 16:59:03 GMT 2025 , Edited by admin on Tue Apr 01 16:59:03 GMT 2025

PRIMARY

PUBCHEM

6918634

Created by admin on Tue Apr 01 16:59:03 GMT 2025 , Edited by admin on Tue Apr 01 16:59:03 GMT 2025

PRIMARY

Related Record Type Details


					Y73947J3R5

BGC-20-1259

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					Y73947J3R5

BGC-20-1259

ACTIVE MOIETY

Comments:

The compound was as effective as SERT inhibitors such as fluoxetine and fluvoxamine in a 5-hydroxytryptophan-enhancing test in mice. Spatial memory deficits in the two-platform task of a water maze in aged rats were ameliorated by RS-1259 as well as donepezil. Both RS-1259 and donepezil increased the awake episodes in the daytime electroencephalogram of rats. The efficacy of RS-1259 on the consciousness level, which reflects the whole activity in the brain, was almost the same as that of donepezil. These results suggest that both cholinergic and serotonergic systems are involved in maintaining brain arousal and that a dual inhibitor of AChE and SERT may be useful for the treatment of cognitive disorders associated with reduced brain activity such as in Alzheimer's disease.

Amount: