KAEMPFEROL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H10O6
Molecular Weight	286.2363
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O

InChI

InChIKey=IYRMWMYZSQPJKC-UHFFFAOYSA-N

InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H

HIDE SMILES / InChI

Molecular Formula	C15H10O6
Molecular Weight	286.2363
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21428901 | https://www.ncbi.nlm.nih.gov/pubmed/25982933 | https://www.ncbi.nlm.nih.gov/pubmed/24578792

Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many edible plants (e.g. tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries and grapes) and in plants or botanical products commonly used in traditional medicine (e.g. Ginkgo biloba, Tilia spp, Equisetum spp, Moringa oleifera, Sophora japonica and propolis). Numerous preclinical studies have shown that kaempferol and some glycosides of kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, anti-osteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic activities.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Potency
DNA topoisomerase II 66 Target ID: CHEMBL2094255 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26419945	Inhibitor 8504
Ribosomal protein S6 kinase alpha 3 5 Target ID: CHEMBL2345 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24994661	Inhibitor 8504
Ribosomal protein S6 kinase alpha 5 3 Target ID: CHEMBL4237 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24994661	Inhibitor 8504
Monoamine oxidase A 52 Target ID: CHEMBL1951 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10813558	Inhibitor 8504	0.7 µM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Cancer 609 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24578792 https://www.ncbi.nlm.nih.gov/pubmed/26323894 https://www.ncbi.nlm.nih.gov/pubmed/26878784 https://www.ncbi.nlm.nih.gov/pubmed/26883800	Primary	Preclinical	Unknown Approved Use Unknown
Depression 240 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22110339	Primary	Preclinical	Unknown Approved Use Unknown
Osteoarthritis 157 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27330526	Primary	Phase II 1147	Unknown Approved Use Unknown

C_max

Value	Dose	Co-administered	Analyte	Population
1.43 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26051640	6 mg/kg single, oral dose: 6 mg/kg route of administration: Oral experiment type: SINGLE co-administered:		KAEMPFEROL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
17.72 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26051640	6 mg/kg single, oral dose: 6 mg/kg route of administration: Oral experiment type: SINGLE co-administered:		KAEMPFEROL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
5.11 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26051640	6 mg/kg single, oral dose: 6 mg/kg route of administration: Oral experiment type: SINGLE co-administered:		KAEMPFEROL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

Sourcing

Vendor/Aggregator	ID	URL
1PlusChem LLC	1P003A28	https://www.1pchem.com/search?query=1P003A28
A2B Chem	AB52208	http://a2bchem.com/prod/AB52208
Accela ChemBio Inc	SY023424	http://accelachem.com/cn/search.html?keyword=SY023424&attname=0
Achemo Scientific Limited	AC-106690	http://www.achemo.com/search/?Keyword=AC-106690
AK Scientific	C554	https://aksci.com/item_detail.php?cat=C554
AK Scientific	J10449	https://aksci.com/item_detail.php?cat=J10449
AK Scientific	W1682	https://aksci.com/item_detail.php?cat=W1682
Ambeed	A272671	http://www.ambeed.com/search/Search.html?keyword=A272671
Angene	AGN-PC-088NKM	http://www.angenechemical.com/productshow/AGN-PC-088NKM.html
ApexBio Technology	N1719	https://www.apexbt.com/catalogsearch/result/?q=N1719
AstaTech	H10428	http://astatechinc.com/CPSResult.php?CRNO=H10428
Biopurify Phytochemicals	BP0820	https://www.phytopurify.com/search.do?a=s&searchtype=3&psize=10&q=BP0820&searchhtmp=simplesearch&t=1
BioSynth	Q-100584	https://www.biosynth.com/en/products/life-science/other-biochemicals/products/Q-100584
BOC Sciences	520-18-3	http://www.bocsci.com/description.asp?cas=520-18-3
Cayman Chemical	11852	http://www.caymanchem.com/app/template/Product.vm/catalog/11852
Chem Scene	CS-1273	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-1273
ChemShuttle	141536	https://www.chemshuttle.com/catalogsearch/result/?q=141536
Combi-Blocks	QA-0803	http://www.combi-blocks.com/cgi-bin/find.cgi?QA-0803
Combi-Blocks	QC-5720	http://www.combi-blocks.com/cgi-bin/find.cgi?QC-5720
eMolecules	50377688	https://orderbb.emolecules.com/search/#?query=50377688
eMolecules	524531	https://orderbb.emolecules.com/search/#?query=524531
Enamine	EN300-205764	https://www.enaminestore.com/catalog/EN300-205764
Enamine	EN300-206857	https://www.enaminestore.com/catalog/EN300-206857
eNovation Chemicals	D693235	https://www.enovationchem.com/Products.asp?SEARCHTEXT=D693235&searchbtn.x=0&searchbtn.y=0
Frontier Scientific Services	501003636	http://orders.frontierssi.com/fssionline32/public/product.aspx?cat=501003636&type=hts
Hairui	HR122347	http://www.hairuichem.com/en/product/search.do?q=HR122347
Indofine	021123S	https://indofinechemical.com/details.aspx?Sku=021123S
Indofine	021124S	https://indofinechemical.com/details.aspx?Sku=021124S
Indofine	021243S	https://indofinechemical.com/details.aspx?Sku=021243S
Indofine	K-102	https://indofinechemical.com/details.aspx?Sku=K-102
KeyOrganics	GS-3570	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=GS-3570
Lab Network	LN00008740	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00008740
Lab Seeker	SC-17291	http://www.labseeker.com/search.php?keywords=SC-17291&category=0
LabSeeker	SC-17291	http://www.labseeker.com/search.php?keywords=SC-17291&category=0
mcule	MCULE-8965218413	https://mcule.com/MCULE-8965218413/
MedChem Express	HY-14590	https://www.medchemexpress.com/search.html?q=HY-14590&ft=&fa=&fp=
Molnova	M14822	https://www.molnova.com/en/serch-list.html?keywords=M14822
MolPort	MolPort-001-741-568	https://www.molport.com/shop/molecule-link/MolPort-001-741-568
PI Chemicals	PI-14733	http://www.pipharm.com/catalog_products/PI-14733.html
Selleck Chemicals	S2314	http://www.selleckchem.com/search.html?searchDTO.searchParam=S2314
ShangHai Biochempartner	BCP20472	http://www.biochempartner.com/search_BCP20472
TargetMol	BBP00243	https://www.targetmol.com/search?keyword=BBP00243
TargetMol	T2177	https://www.targetmol.com/search?keyword=T2177
Tetrahedron	TS77144	http://www.thsci.com/search.do?q=TS77144
TimTec	SBB066091	http://www.echemstore.com/catalogsearch/result/?q=SBB066091
TimTec	ST030560	http://www.echemstore.com/catalogsearch/result/?q=ST030560
Tocris	3603	https://www.tocris.com/search.php?Type=QuickSearch&Value=3603
Toronto Research Chemicals	B692910	https://www.trc-canada.com/product-detail/?CatNum=B692910
Toronto Research Chemicals	K100000	https://www.trc-canada.com/product-detail/?CatNum=K100000
W&J PharmaChem	50A258643	http://wjpharmachem.com/new/searcht.php?keyword=50A258643

PubMed

Title	Date	PubMed
Antioxidative phenolic compounds isolated from almond skins (Prunus amygdalus Batsch).	2002-04-10	11929314
Phenolic compounds and antioxidant capacity of Georgia-grown blueberries and blackberries.	2002-04-10	11929309
Selective responses of three Ginkgo biloba leaf-derived constituents on human intestinal bacteria.	2002-03-27	11902921
Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols.	2002-03-15	11931850
Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L.	2002-03-06	11876448
Flavonoids from the flowers of Prunus spinosa L.	2002-03-06	11876444
Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter.	2002-03-01	11864778
Antioxidant activity of flavonoids from Licania licaniaeflora.	2002-03	11849846
Hepatoprotective principles from the flowers of Tilia argentea (linden): structure requirements of tiliroside and mechanisms of action.	2002-03	11814859
Phytochemical and pharmacological analysis of Bauhinia microstachya (Raddi) Macbr. (Leguminosae).	2002-02-12	11837679
The role of UV-B radiation in aquatic and terrestrial ecosystems--an experimental and functional analysis of the evolution of UV-absorbing compounds.	2002-02	11849977
Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9.	2002-02	11792676
Isolation and characterization of stelladerol, a new antioxidant naphthalene glycoside, and other antioxidant glycosides from edible daylily (hemerocallis) flowers.	2002-01-02	11754548
Flavonoid gene expression and UV photoprotection in transgenic and mutant Petunia leaves.	2002-01	11754940
A pharmacophore for human pregnane X receptor ligands.	2002-01	11744617
Inhibition of nitric oxide synthase expression by a methanolic extract of Crescentia alata and its derived flavonols.	2001-12-21	11811897
Ethyl m-digallate from red maple, Acer rubrum L., as the major resistance factor to forest tent caterpillar, Malacosoma disstria Hbn.	2001-12	11789956
Proposed active constituents of Dipladenia martiana.	2001-12	11746866
Coumaroyl flavonol glycosides from the leaves of Ginkgo biloba.	2001-12	11738417
A new C-methylated flavonoid glycoside from Pinus densiflora.	2001-12	11731124
Flavonoids and UV photoprotection in Arabidopsis mutants.	2001-11-29	11724379
Kaempferol and its glycosides in the seeds hair of Asclepias syriaca L.	2001-11-20	11712739
Direct extraction of specific pharmacophoric flavonoids from gingko leaves using a molecularly imprinted polymer for quercetin.	2001-11-16	11762756
Kaempferol, isorhamnetin and their glycosides in the flowers of Asclepias syriaca L.	2001-11-06	11693731
Effects of flavonols on the generation of superoxide anion radicals by xanthine oxidase and stimulated neutrophils.	2001-11-01	11673865
In vitro anti-inflammatory effects of quercetin 3-O-methyl ether and other constituents from Rhamnus species.	2001-11	11731918
A stabilized flavonoid glycoside in heat-treated Cassia alata leaves and its structural elucidation.	2001-11	11725550
Flavonol glycosides from the flowers of Bellis perennis.	2001-11	11677029
Phenolic compounds in seven South American Ilex species.	2001-11	11677016
Antioxidant ability of various flavonoids against DPPH radicals and LDL oxidation.	2001-10	11814152
Antioxidative components from the aerial parts of Lactuca scariola L.	2001-10	11693545
Effect of plant growth temperature on antioxidant capacity in strawberry.	2001-10	11600054
Indolopyridoquinazoline alkaloid from Leptothyrsa sprucei.	2001-10	11576612
Flavonol glycosides from the stems of Trigonella foenum-graecum.	2001-10	11576601
Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3.	2001-09-15	11535118
Alkaline phosphatase from rat liver and kidney is differentially modulated.	2001-09	11676975
Determination of flavonoids and stilbenes in red wine and related biological products by HPLC and HPLC-ESI-MS-MS.	2001-09	11605763
Polyphenolic compounds: interactions with the gut and implications for human health.	2001-09	11562264
Antipruritic and antidermatitic effect of extract and compounds of Impatiens balsamina L. in atopic dermatitis model NC mice.	2001-09	11536380
Electrochemical behaviors of quercetin and kaempferol in neutral buffer solution.	2001-08	11708106
Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat.	2001-08	11545625
Four new isoflavone triglycosides from Sophora japonica.	2001-08	11520241
Medicinal foodstuffs. XXV. Hepatoprotective principle and structures of ionone glucoside, phenethyl glycoside, and flavonol oligoglycosides from young seedpods of garden peas, Pisum sativum L.	2001-08	11515568
Effect of processing and storage on the antioxidant ellagic acid derivatives and flavonoids of red raspberry (Rubus idaeus) jams.	2001-08	11513642
Cytotoxicity and lipid peroxidation-inhibiting activity of flavonoids.	2001-08	11509970
Inhibitory activity for chitin synthase II from Saccharomyces cerevisiae by tannins and related compounds.	2001-08	11509967
[Comparison of photometric, electrochemical and post-column fluorescence detection for the determination of flavonoids by HPLC].	2001-06	11577389
Flavonoids and urate antioxidant interplay in plasma oxidative stress.	2001-05	11506190
Medicinal and ethnoveterinary remedies of hunters in Trinidad.	2001	11737880
Induction of glutathione synthesis in human keratinocytes by Ginkgo biloba extract (EGb761).	2001	11673643

Patents

Sample Use Guides

In Vivo Use Guide

humans: orally as a component of plant (e.g. Elaeagnus Angustifolia or Ginkgo Biloba) extracts. mice: 100 mg/kg/d, p. o. for 6 weeks. rats: 20 mg/kg; i.p. daily for a period of 28 days.

Route of Administration: Other

In Vitro Use Guide

50 μM of kaempferol specifically inhibited the cell viability by approximately 40% in Miapaca-2 cells, 15% in Panc-1 cells, and 10% in SNU-213 cells

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:48:00 GMT 2025` Edited by `admin` on `Mon Mar 31 18:48:00 GMT 2025`
Record UNII	731P2LE49E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

KAEMPFEROL

Official Name

English

PELARGIDENOLON 1497

Preferred Name

English

CI 75640

Common Name

English

KAEMPFEROL [IARC]

Common Name

English

SWARTZIOL

Common Name

English

NIMBECETIN

Common Name

English

NSC-656277

Code

English

3'-DEOXYQUERCETIN

Common Name

English

3,4',5,7-TETRAHYDROXYFLAVONE

Systematic Name

English

KAEMPFEROL (CONSTITUENT OF GINKGO) [DSC]

Common Name

English

PELARGIDENON

Common Name

English

KAEMPHEROL

Common Name

English

RHAMNOLUTEIN

Common Name

English

4H-1-BENZOPYRAN-4-ONE, 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-

Systematic Name

English

3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE

Systematic Name

English

5,7,4'-TRIHYDROXYFLAVONOL

Systematic Name

English

POPULNETIN

Common Name

English

FLAVONE, 3,4',5,7-TETRAHYDROXY-

Systematic Name

English

KAMPCETIN

Common Name

English

ROBIGENIN

Common Name

English

C.I. 75640

Common Name

English

KAEMPFEROL [USP-RS]

Common Name

English

KAEMPFEROL [HSDB]

Common Name

English

KAEMPFEROL [MI]

Common Name

English

INDIGO YELLOW

Common Name

English

NSC-407289

Code

English

TRIFOLITIN

Common Name

English

Classification Tree Code System Code

DSLD

1221 (Number of products:6)