CLOFARABINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H11ClFN5O3
Molecular Weight	303.677
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CLOFARABINE

Structure Search

SMILES

NC1=NC(Cl)=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3F

InChI

InChIKey=WDDPHFBMKLOVOX-AYQXTPAHSA-N

InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H11ClFN5O3
Molecular Weight	303.677
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:34:47 UTC 2023` Edited by `admin` on `Fri Dec 15 15:34:47 UTC 2023`
Record UNII	762RDY0Y2H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOFARABINE

Official Name

English

CLOFARABINE [VANDF]

Common Name

English

CLOFARABINE [MI]

Common Name

English

9H-PURIN-6-AMINE, 2-CHLORO-9-(2-DEOXY-2-FLUORO-.BETA.-D-ARABINOFURANOSYL)

Common Name

English

CLOLAR

Brand Name

English

clofarabine [INN]

Common Name

English

CLOFARABINE [ORANGE BOOK]

Common Name

English

Clofarabine [WHO-DD]

Common Name

English

NSC-759857

Code

English

CLOFARABINE [EMA EPAR]

Common Name

English

CLOFARABINE [USAN]

Common Name

English

CLOFARABINE [MART.]

Common Name

English

EVOLTRA

Brand Name

English

CLOFARABINE [JAN]

Common Name

English

2-CHLORO-9-(2-DEOXY-2-FLUORO-.BETA.-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

668118

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

NDF-RT

N0000000233

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

FDA ORPHAN DRUG

153201

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

NCI_THESAURUS

C1556

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

WHO-VATC

QL01BB06

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

EMA ASSESSMENT REPORTS

EVOLTRA (AUTHORIZED: PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA)

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

NDF-RT

N0000175595

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

FDA ORPHAN DRUG

154802

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

LIVERTOX

NBK548185

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

WHO-ATC

L01BB06

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

NCI_THESAURUS

C2150

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

Code System Code Type Description

RXCUI

44151

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

RxNorm

FDA UNII

762RDY0Y2H

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

NSC

759857

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

EPA CompTox

DTXSID5046437

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

DRUG BANK

DB00631

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

ChEMBL

CHEMBL1750

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

EU-Orphan Drug

EU/3/01/082(EXPIRED)

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

Please note that this product was withdrawn from the Community Register of designated orphan medicinal products in May 2016 at the end of the period of market exclusivity. On 5 February 2002, orphan designation (EU/3/01/082) was granted by the European Commission to ILEX Services Limited, United Kingdom, for 2-chloro-9-[2-deoxy-2-fluoro-ß-D-arabinofuranosyl]adenine for the treatment of acute lymphoblastic leukaemia (ALL). The sponsorship was transferred to Bioenvision, United Kingdom, in December 2002 and subsequently to Genzyme Europe BV, The Netherlands, in May 2008. Update: 2-chloro-9-[2-deoxy-2-fluoro-ß-D-arabinofuranosyl]adenine has been authorised in the European Union as Evoltra since 29 May 2006.

INN

8422

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

WIKIPEDIA

CLOFARABINE

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

DRUG CENTRAL

691

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

EVMPD

SUB21902

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

SMS_ID

100000089587

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

MESH

C068329

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

MERCK INDEX

m3636

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

Merck Index

IUPHAR

6802

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

PUBCHEM

119182

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

CHEBI

681569

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

CAS

123318-82-1

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

EU-Orphan Drug

EU/3/03/141(WITHDRAWN)

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

Please note that this product was withdrawn from the Community Register of designated Orphan Medicinal Products in July 2014 on request of the Sponsor. On 8 May 2003, orphan designation (EU/3/03/141) was granted by the European Commission to Bioenvision Limited, United Kingdom, for 2-chloro-9-[2-deoxy-2’-fluoro-ß-D-arabinofuranosyl]adenine for the treatment of acute myeloid leukaemia. The sponsorship was transferred to Genzyme Europe BV, The Netherlands, in May 2008.

NCI_THESAURUS

C26638

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

USAN

OO-77

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

DAILYMED

762RDY0Y2H

Created by admin on Fri Dec 15 15:34:47 UTC 2023 , Edited by admin on Fri Dec 15 15:34:47 UTC 2023

PRIMARY

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Interaction Type:

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LABELED -> NON-LABELED

Amount:

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Amount:

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ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC