ZATOSETRON MALEATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H25ClN2O2.C4H4O4
Molecular Weight	464.939
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)NC(=O)C3=CC(Cl)=CC4=C3OC(C)(C)C4

InChI

InChIKey=HAFQATMFFHYNPN-QRPZPOMXSA-N

InChI=1S/C19H25ClN2O2.C4H4O4/c1-19(2)10-11-6-12(20)7-16(17(11)24-19)18(23)21-13-8-14-4-5-15(9-13)22(14)3;5-3(6)1-2-4(7)8/h6-7,13-15H,4-5,8-10H2,1-3H3,(H,21,23);1-2H,(H,5,6)(H,7,8)/b;2-1-/t13-,14+,15-;

HIDE SMILES / InChI

Molecular Formula	C19H25ClN2O2
Molecular Weight	348.867
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1732548 | https://www.ncbi.nlm.nih.gov/pubmed/7984290 | https://www.ncbi.nlm.nih.gov/pubmed/7517409 | https://www.ncbi.nlm.nih.gov/pubmed/10211913

Zatosetron is a potent, selective, orally effective 5HT3 receptor antagonist. It has been studied in the treatment of emesis, migraine and anxiety.

CNS Activity

Originator

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:38:34 GMT 2025` Edited by `admin` on `Mon Mar 31 18:38:34 GMT 2025`
Record UNII	7I5347HD9B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZATOSETRON MALEATE

Official Name

English

LY-277359 MALEATE

Preferred Name

English

ZATOSETRON MALEATE [USAN]

Common Name

English

7-BENZOFURANCARBOXAMIDE, 5-CHLORO-2,3-DIHYDRO-2,2-DIMETHYL-N-(8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL)-, ENDO-, (Z)-2-BUTENEDIOATE (1:1)

Common Name

English

7-BENZOFURANCARBOXAMIDE, 5-CHLORO-2,3-DIHYDRO-2,2-DIMETHYL-N-((3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL)-, (2Z)-2-BUTENEDIOATE (1:1)

Common Name

English

LY277359 MALEATE

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C94726