INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 19:42:53 GMT 2025` Edited by `admin` on `Tue Apr 01 19:42:53 GMT 2025`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	8M3QXTKGO1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IRAK-4

Preferred Name

English

INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4

Common Name

English

RENAL CARCINOMA ANTIGEN NY-REN-64

Common Name

English

Code System Code Type Description

PHAROS

Q9NWZ3

Created by admin on Tue Apr 01 19:42:53 GMT 2025 , Edited by admin on Tue Apr 01 19:42:53 GMT 2025

PRIMARY

UNIPROT

Q9NWZ3

Created by admin on Tue Apr 01 19:42:53 GMT 2025 , Edited by admin on Tue Apr 01 19:42:53 GMT 2025

PRIMARY

FDA UNII

8M3QXTKGO1

Created by admin on Tue Apr 01 19:42:53 GMT 2025 , Edited by admin on Tue Apr 01 19:42:53 GMT 2025

PRIMARY

WIKIPEDIA

IRAK4

Created by admin on Tue Apr 01 19:42:53 GMT 2025 , Edited by admin on Tue Apr 01 19:42:53 GMT 2025

PRIMARY

Related Record Type Details


					S3F315JJXI

ZIMLOVISERTIB

INHIBITOR -> TARGET

Amount:


					5759XTJ706

DELMITIDE

INHIBITOR -> TARGET

Amount:


					MH5DMF9JKY

Emavusertib

INHIBITOR -> TARGET


					2SXR65P7E3

KT-474

DEGRADER->TARGET

Comments:

KT-474 is a targeting IRAK4 and the E3 ligase CRBN to mediate the selective degradation of IRAK4 via the ubiquitin-proteasome system (UPS)

Amount:


					N1GRK350ZM

ZABEDOSERTIB

INHIBITOR -> TARGET

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_346]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL