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Details

Stereochemistry ACHIRAL
Molecular Formula C14H16N2.ClH
Molecular Weight 248.751
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NAPACTADINE HYDROCHLORIDE

SMILES

Cl.CN\C(CC1=CC=C2C=CC=CC2=C1)=N/C

InChI

InChIKey=WEDBCIMSKMMRAG-UHFFFAOYSA-N
InChI=1S/C14H16N2.ClH/c1-15-14(16-2)10-11-7-8-12-5-3-4-6-13(12)9-11;/h3-9H,10H2,1-2H3,(H,15,16);1H

HIDE SMILES / InChI
Molecular Formula C14H16N2
Molecular Weight 212.2902
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Napactadine is a bicyclic antidepressant agent. It is a histamine-H1 receptor antagonist. Preliminary results indicated a marked improvement in depressive symptomalology within 7 days of treatment, as measured by the Hamilton depression scale. However, clinical studies were discontinued after chronic administration of napactadine because an elevation in liver enzyme levels was observed in some patients.

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
New bicyclic antidepressant agent. Synthesis and activity of napactadine and related compounds.
1985-11
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:29:57 GMT 2025
Edited
by admin
on Mon Mar 31 18:29:57 GMT 2025
Record UNII
9FB1F1BV0M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NAPACTADINE HYDROCHLORIDE
MART.   USAN  
USAN  
Official Name English
DL-588
Preferred Name English
2-NAPHTHALENEETHANIMIDAMIDE, N,N'-DIMETHYL-, MONOHYDROCHLORIDE
Common Name English
NAPACTADINE HYDROCHLORIDE [MART.]
Common Name English
NAPACTADINE HCL
Common Name English
NAPACTADINE HYDROCHLORIDE [USAN]
Common Name English
N,N'-DIMETHYL-2-NAPHTHALENEACETAMIDINE MONOHYDROCHLORIDE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29578
Created by admin on Mon Mar 31 18:29:57 GMT 2025 , Edited by admin on Mon Mar 31 18:29:57 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C83984
Created by admin on Mon Mar 31 18:29:57 GMT 2025 , Edited by admin on Mon Mar 31 18:29:57 GMT 2025
PRIMARY
CAS
57166-13-9
Created by admin on Mon Mar 31 18:29:57 GMT 2025 , Edited by admin on Mon Mar 31 18:29:57 GMT 2025
PRIMARY
EPA CompTox
DTXSID80972630
Created by admin on Mon Mar 31 18:29:57 GMT 2025 , Edited by admin on Mon Mar 31 18:29:57 GMT 2025
PRIMARY
PUBCHEM
42152
Created by admin on Mon Mar 31 18:29:57 GMT 2025 , Edited by admin on Mon Mar 31 18:29:57 GMT 2025
PRIMARY
SMS_ID
300000055529
Created by admin on Mon Mar 31 18:29:57 GMT 2025 , Edited by admin on Mon Mar 31 18:29:57 GMT 2025
PRIMARY
FDA UNII
9FB1F1BV0M
Created by admin on Mon Mar 31 18:29:57 GMT 2025 , Edited by admin on Mon Mar 31 18:29:57 GMT 2025
PRIMARY
ChEMBL
CHEMBL1192539
Created by admin on Mon Mar 31 18:29:57 GMT 2025 , Edited by admin on Mon Mar 31 18:29:57 GMT 2025
PRIMARY
Related Record Type Details
Structure of NAPACTADINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of NAPACTADINE
ACTIVE MOIETY
NIH
NCATS
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