HOQUIZIL HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H26N4O5.ClH
Molecular Weight	426.894
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC2=NC=NC(N3CCN(CC3)C(=O)OCC(C)(C)O)=C2C=C1OC

InChI

InChIKey=UGBDUZVYTXIXHU-UHFFFAOYSA-N

InChI=1S/C19H26N4O5.ClH/c1-19(2,25)11-28-18(24)23-7-5-22(6-8-23)17-13-9-15(26-3)16(27-4)10-14(13)20-12-21-17;/h9-10,12,25H,5-8,11H2,1-4H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H26N4O5
Molecular Weight	390.4335
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4912116 | https://www.ncbi.nlm.nih.gov/pubmed/6276530

Hoquizil, a phosphodiesterase inhibitor, was used as a bronchodilator agent. Information about the current use of this drug is not available.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
phosphoric diester hydrolase activity 4 Target ID: GO:0008081 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6276530	Inhibitor 8504

PubMed

Title	Date	PubMed
Heterogeneity of biochemical actions among vasodilators.	1982-01	6276530
Quinazolines in man. Metabolism and preliminary evaluation of piquizil and hoquizil, two bronchodilators.	1971	4946165
Hoquizil--a new oral bronchodilator. A double-blind, randomized, coded clinical study using body plethysmography.	1969	4912116

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:49:30 GMT 2025` Edited by `admin` on `Mon Mar 31 17:49:30 GMT 2025`
Record UNII	9I598ZX18I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CP-14,185-1

Preferred Name

English

HOQUIZIL HYDROCHLORIDE

Official Name

English

HOQUIZIL HYDROCHLORIDE [USAN]

Common Name

English

HOQUIZIL HCL

Common Name

English

1-PIPERAZINECARBOXYLIC ACID, 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-, 2-HYDROXY-2-METHYLPROPYL ESTER, MONOHYDROCHLORIDE

Common Name

English

CP-14185-1

Code

English

2-Hydroxy-2-methylpropyl 4-(6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylate monohydrochloride

Systematic Name

English

Code System Code Type Description

ChEMBL

CHEMBL2110858