ADENOSINE RECEPTOR A1

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 18:08:06 GMT 2025` Edited by `admin` on `Tue Apr 01 18:08:06 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	9J6QGP7WEA
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ADENOSINE RECEPTOR A1

Common Name

English

ADORA1

Preferred Name

English

Adenosine A1

Common Name

English

Adenosine A1 receptor

Common Name

English

Code System Code Type Description

UNIPROT

P30542

Created by admin on Tue Apr 01 18:08:06 GMT 2025 , Edited by admin on Tue Apr 01 18:08:06 GMT 2025

PRIMARY

FDA UNII

9J6QGP7WEA

Created by admin on Tue Apr 01 18:08:06 GMT 2025 , Edited by admin on Tue Apr 01 18:08:06 GMT 2025

PRIMARY

From	To
1_80	1_169

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_159

Related Record Type Details


					8GG6N4T6DD

NECA H3

RADIOLIGAND->TARGET

Qualification:

Ki

Amount:


					0I55128JYK

THEOPHYLLINE ANHYDROUS

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					O1Q96UZ63W

DERENOFYLLINE

INHIBITOR -> TARGET

Amount:


					770140J08A

IMARADENANT

WEAK INHIBITOR->TARGET

Qualification:

Ki

Amount:


					2GZ0LIK7T4

ISTRADEFYLLINE

WEAK INHIBITOR->TARGET

Qualification:

Ki

Amount:


					K72T3FS567

ADENOSINE

AGONIST -> TARGET

Qualification:

Ki

Amount:


					A937Z0MS6C

MIDAXIFYLLINE

INHIBITOR -> TARGET

Amount:


					7RZ2348VW5

AST-004

AGONIST -> TARGET

Amount:


					GZ1X96601Z

TECADENOSON

AGONIST -> TARGET

Amount:


					UK37HM0CDG

GP-531

AGONIST -> TARGET

Amount:


					VZ2KZF4L9S

Neladenoson

PARTIAL AGONIST->TARGET

Amount:


					5NIC36BO71

ZM-241385

WEAK INHIBITOR->TARGET

Qualification:

Ki

Amount:


					1T237110W4

TRABODENOSON

AGONIST -> TARGET

Amount:


					83VNU4U44T

TONAPOFYLLINE

INHIBITOR -> TARGET

Amount:


					7LG47VG1ID

N-CYCLOPENTYLADENOSINE

AGONIST -> TARGET

Comments:

Binding assay

Qualification:

IC50

Amount:


					VS58MO4P47

BMS-986299

INHIBITOR->OFF-TARGET


					7805S5HIHX

ROLOFYLLINE

INHIBITOR -> TARGET

Amount:


					T5HB1E831H

CGS-21680

WEAK INHIBITOR->OFF TARGET

Comments:

Binding Assay

Qualification:

IC50

Amount:


					B3G45WC37L

NAXIFYLLINE

INHIBITOR -> TARGET

Amount:


					263T0E9RR9

DYPHYLLINE

INHIBITOR -> TARGET


					O519NVW73R

CAPADENOSON

PARTIAL AGONIST->TARGET

Amount:


					NB2H3PD83X

FK-3453

INHIBITOR -> TARGET

Amount:


					D9K857J81I

TOZADENANT

WEAK INHIBITOR->TARGET

Amount:


					3G6A5W338E

CAFFEINE

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					Y29E2DV2VU

ATL-444

INHIBITOR -> TARGET

Amount:


					08W5N2C97Q

ALPELISIB

INHIBITOR->OFF-TARGET

Qualification:

IC50

Amount:


					CYL2BF4PS8

DPCPX H-3

LIGAND->TARGET

Qualification:

Kd

Amount:


					I89Y79062L

ETAZOLATE

INHIBITOR -> TARGET


					84I5UEP321

TAMINADENANT

WEAK INHIBITOR->TARGET

Qualification:

Ki

Amount:


					W0ZE0NT8IF

ETRUMADENANT

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					OG8HSX6N6H

APAXIFYLLINE

INHIBITOR -> TARGET

Amount:


					Q4H682B2VZ

GR-79236

AGONIST -> TARGET

Comments:

Rat brain receptor

Interaction Type:

BINDING

Qualification:

Ki

Amount:


					103G5E953K

SELODENOSON

AGONIST -> TARGET

Amount:


					Y5A5D5E2AQ

CGS-15943

INHIBITOR -> TARGET


					9PTP4FOI9E

8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					8KFO2187CP

CIFORADENANT

INHIBITOR -> TARGET

Qualification:

Ki

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_309]	SITE_SPECIFIC			S-PALMITOYL CYSTEINE	08WQ73S7SV

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL