KELCH-LIKE ECH-ASSOCIATED PROTEIN 1

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:48:19 GMT 2025` Edited by `admin` on `Wed Apr 02 12:48:19 GMT 2025`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	A23SUA4F82
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

KELCH-LIKE ECH-ASSOCIATED PROTEIN 1

Common Name

English

CYTOSOLIC INHIBITOR OF NRF2

Preferred Name

English

KEAP1 PROTEIN

Common Name

English

INRF2

Common Name

English

KELCH-LIKE PROTEIN 19

Common Name

English

Code System Code Type Description

FDA UNII

A23SUA4F82

Created by admin on Wed Apr 02 12:48:20 GMT 2025 , Edited by admin on Wed Apr 02 12:48:20 GMT 2025

PRIMARY

UNIPROT

Q9Z2X8

Created by admin on Wed Apr 02 12:48:20 GMT 2025 , Edited by admin on Wed Apr 02 12:48:20 GMT 2025

PRIMARY

Related Record Type Details


					GA49J4310U

SULFORAPHANE

INACTIVATOR->TARGET

Comments:

Reacts with reactive cysteine residues through covalent modification, resulting in the conformational changes of Keap1 and the release of Nrf2 from Keap1.

Amount:


					CEG1Q6OGU1

BARDOXOLONE METHYL

LIGAND->TARGET

Amount:


					CEG1Q6OGU1

BARDOXOLONE METHYL

INHIBITOR OF PROTEIN-PROTEIN INTERACTION->TARGET

Comments:

Bardoxolone methyl covalently binds to the reactive cysteine residue(s) of Keap1, releasing Nrf2 from the proteasome pathway into the nucleus.

Amount:


					1N19AGY57Y

CXA-10

INHIBITOR -> TARGET

Comments:

Targeting the surface cysteines

Interaction Type:

IRREVERSIBLE INHIBITOR

Amount:


					49QAH60606

BAICALEIN

INACTIVATOR->TARGET

Comments:

Baicalein exerts its effects by inactivating Keap1 through interaction with the cysteine thiol residues of Keap1, subsequently inducing Nrf2 nuclear translocation.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_257] [1_273]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	14c3e0af (not in database)
AMINO_ACID_SUBSTITUTION	[1_38] [1_241] [1_319] [1_613]	SITE_SPECIFIC			S-(2-SUCCINYL)CYSTEINE	DT9KEV171H

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL