MELATONIN MT1 RECEPTOR

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 18:36:40 GMT 2025` Edited by `admin` on `Tue Apr 01 18:36:40 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	C23A33SC67
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEL1A RECEPTOR

Preferred Name

English

MELATONIN MT1 RECEPTOR

Common Name

English

MELATONIN RECEPTOR TYPE 1A

Common Name

English

MTNR1A

Common Name

English

MELATONIN RECEPTOR 1

Common Name

English

MELATONIN RECEPTOR TYPE 1

Common Name

English

MT1

Common Name

English

Code System Code Type Description

FDA UNII

C23A33SC67

Created by admin on Tue Apr 01 18:36:40 GMT 2025 , Edited by admin on Tue Apr 01 18:36:40 GMT 2025

PRIMARY

UNIPROT

P48039

Created by admin on Tue Apr 01 18:36:40 GMT 2025 , Edited by admin on Tue Apr 01 18:36:40 GMT 2025

PRIMARY

From	To
1_100	1_177

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_4
N	1_10

Related Record Type Details


					901AS54I69

RAMELTEON

AGONIST -> TARGET

Comments:

HUMAN RECEPTOR IN CHO CELLS

Qualification:

Ki

Amount:


					CVL1MSR5Z2

CMX-020

AGONIST -> TARGET


					3ZX95B1ZWK

TIK-301

AGONIST -> TARGET

Interaction Type:

IN-VITRO

Qualification:

Ki

Amount:


					P4VWQ9NHF2

(S)-2-HYDROXY-RAMELTEON

AGONIST -> TARGET

Interaction Type:

AGONIST

Qualification:

Ki

Amount:


					SHS4PU80D9

TASIMELTEON

AGONIST -> TARGET


					137R1N49AD

AGOMELATINE

AGONIST -> TARGET

Interaction Type:

AGONIST

Qualification:

Ki

Amount:


					S3UN2146K9

PIROMELATINE

AGONIST -> TARGET

Amount:


					JM8C1SFX0U

Danicopan

INHIBITOR->OFF-TARGET

Comments:

IC50 values for the human melatonin receptor (in vitro) are notably lower (2-fold to 11-fold) than the danicopan concentration expected to be achieved at the MRHD it.

Qualification:

IC50

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL