DESMETHYLSERTRALINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H15Cl2N
Molecular Weight	292.203
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@H]1CC[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=CC=CC=C13

InChI

InChIKey=SRPXSILJHWNFMK-ZBEGNZNMSA-N

InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2/t11-,16-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H15Cl2N
Molecular Weight	292.203
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Partial compliance as determined from plasma levels of sertraline and its metabolite in depressed patients in primary care.	2010-12	21057244
Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry.	2009-11	18839201
Analysis of second-generation antidepressant drug, sertraline and its active metabolite, N-desmethyl sertraline in human plasma by a sensitive and selective liquid chromatography-tandem mass spectrometry method.	2009-01-15	19109078
Addition of risperidone to sertraline improves sertraline-resistant refractory depression without influencing plasma concentrations of sertraline and desmethylsertraline.	2008-12	18803170
Serum concentrations of sertraline and N-desmethyl sertraline in relation to CYP2C19 genotype in psychiatric patients.	2008-12	18677622
Determination of basic antidepressants and their N-desmethyl metabolites in raw sewage and wastewater using solid-phase extraction and liquid chromatography-tandem mass spectrometry.	2008-07-15	18553982
Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway.	2008-03-28	18280486
Identification of primary care patients at risk of nonadherence to antidepressant treatment.	2008-02-02	19920985
Sertraline and its metabolite desmethylsertraline, but not bupropion or its three major metabolites, have high affinity for P-glycoprotein.	2008-02	18239278
Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma.	2007-12-28	18022628
Determination of sertraline and N-desmethylsertraline in human plasma by CE with LIF detection.	2007-06	17450537
Postpartum depression: a randomized trial of sertraline versus nortriptyline.	2006-08	16855451
Conversion of sertraline to N-methyl sertraline in embalming fluid: a forensic implication.	2006-07-29	16872572
HPLC analysis of the second-generation antidepressant sertraline and its main metabolite N-desmethylsertraline in human plasma.	2006-05-19	16581317
Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.	2005-12-09	16314157
QT interval prolongation after sertraline overdose: a case report.	2005-07-19	16029494
Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression.	2005-06	15932816
Determination of select antidepressants in fish from an effluent-dominated stream.	2005-02	15720009
Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations.	2004-11-01	15555696
A pilot study of newer antidepressant concentrations in cord and maternal serum and possible effects in the neonate.	2004-09	15035694
Serum disposition of sertraline, N-desmethylsertraline and paroxetine: a pharmacokinetic evaluation of repeated drug concentration measurements during 6 months of treatment for major depression.	2004-07	15252820
A novel system for the determination of antidepressant concentrations in human breast milk.	2004-02	14749550
Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury.	2003-12	12919933
Effects of an educational compliance enhancement programme and therapeutic drug monitoring on treatment adherence in depressed patients managed by general practitioners.	2003-11	14571155
Inhibition of P-glycoprotein by newer antidepressants.	2003-04	12649369
The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations.	2003-01	12590627
[Postmortem distribution of sertraline and desmethylsertraline in a fatality].	2002-10-09	12365335
Sertraline-induced hypoglycemia.	2001-11	11724085
Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs.	2001-10	11578995
Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19.	2001-07	11452243
Platelet inhibition by sertraline and N-desmethylsertraline: a possible missing link between depression, coronary events, and mortality benefits of selective serotonin reuptake inhibitors.	2001-05	11394937
The selective serotonin reuptake inhibitor sertraline: its profile and use in psychiatric disorders.	2001	11420570

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:10:44 GMT 2025` Edited by `admin` on `Mon Mar 31 22:10:44 GMT 2025`
Record UNII	CJJ71O9BE8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DESMETHYLSERTRALINE

Common Name

English

CP-53261

Preferred Name

English

1-NAPHTHALENAMINE, 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-, (1S,4S)-

Systematic Name

English

NORSERTRALINE

Common Name

English

N-DESMETHYLSERTRALINE

Common Name

English

Code System Code Type Description

PUBCHEM

114743