Nuvisertib hydrochloride

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H25F3N4O.ClH
Molecular Weight	454.916
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)(O)[C@H]1CC[C@@H](CC1)NC2=NN3C(C=C2)=NC=C3C4=CC=CC(=C4)C(F)(F)F

InChI

InChIKey=RJXWMEFBAZTYCY-BFLZMHAMSA-N

InChI=1S/C22H25F3N4O.ClH/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25;/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28);1H/t15-,17-;

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C22H25F3N4O
Molecular Weight	418.4553
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serine/threonine-protein kinase PIM1 13 Target ID: CHEMBL2147 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24953177	Inhibitor 8504		5.0 nM [Ki]
Serine/threonine-protein kinase PIM3 10 Target ID: CHEMBL5407 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24953177	Inhibitor 8504		42.0 nM [Ki]

Substance Class	Chemical Created by `admin` on `Wed Apr 02 03:53:25 GMT 2025` Edited by `admin` on `Wed Apr 02 03:53:25 GMT 2025`
Record UNII	D7A0W431TR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Nuvisertib hydrochloride

Common Name

English

SGI-9481 HYDROCHLORIDE

Preferred Name

English

2-(trans-4-((3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin6-yl)amino)cyclohexyl)propan-2-ol hydrochloride

Systematic Name

English

TP-3654 HYDROCHLORIDE

Code

English

2-(4-((3-(3-(TRIFLUOROMETHYL)PHENYL)IMIDAZO(1,2-B)PYRIDAZIN-6-YL)AMINO)CYCLOHEXYL)PROPAN-2-OL HYDROCHLORIDE

Systematic Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

874922

Created by admin on Wed Apr 02 03:53:25 GMT 2025 , Edited by admin on Wed Apr 02 03:53:25 GMT 2025

Code System Code Type Description

FDA UNII

D7A0W431TR

Created by admin on Wed Apr 02 03:53:25 GMT 2025 , Edited by admin on Wed Apr 02 03:53:25 GMT 2025

PRIMARY

CAS

1418143-09-5

Created by admin on Wed Apr 02 03:53:25 GMT 2025 , Edited by admin on Wed Apr 02 03:53:25 GMT 2025

PRIMARY

SMS_ID

300000048773

Created by admin on Wed Apr 02 03:53:25 GMT 2025 , Edited by admin on Wed Apr 02 03:53:25 GMT 2025

PRIMARY

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