GUAMECYCLINE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C29H38N8O8.2ClH
Molecular Weight	699.583
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)C4=C(C=CC=C4O)[C@@]3(C)O)=C(O)[C@]2(O)C(=O)C(C(=O)NCN5CCN(CC5)C(=N)NC(N)=N)=C1O

InChI

InChIKey=SNUNMHCZVZIEMV-KGHBUBBXSA-N

InChI=1S/C29H38N8O8.2ClH/c1-28(44)13-5-4-6-16(38)17(13)21(39)18-14(28)11-15-20(35(2)3)22(40)19(24(42)29(15,45)23(18)41)25(43)33-12-36-7-9-37(10-8-36)27(32)34-26(30)31;;/h4-6,14-15,20,38,40-41,44-45H,7-12H2,1-3H3,(H,33,43)(H5,30,31,32,34);2*1H/t14-,15-,20-,28+,29-;;/m0../s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C29H38N8O8
Molecular Weight	626.6608
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4565314 | https://www.ncbi.nlm.nih.gov/pubmed/5147865

Guamecycline, a tetracycline derivative was studied in patients with broncho-pulmonary diseases and for the treatment of acute pneumopathies. However, information about the current use of this compound is not available.

Approval Year

PubMed

Title	Date	PubMed
[Guamecycline in the treatment of acute pneumopathies. Clinical research and comparison with other tetracyclines].	1972-11-21	4565314
Guamecycline in bronchial infections due to Diplococcus pneumoniae.	1972-01-01	4156979
[Effects of aerosol administration of guamecycline in patients with broncho-pulmonary diseases].	1971-01-01	5147865
[Inhibiting effects of guamecycline and of tetracycline hydrochloride on antibody-producing cells of the spleen and lymph nodes].	1971-01-01	5106864
Guamecycline and the bronchopulmonary system. Measurement of antibiotic levels in bronchial secretion.	1969-10	5361894
Preliminary report: electron microscopical appearance of human bronchial epithelium after long-term treatment with guamecycline by aerosol route.	1969	5406225

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Respiratory

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:10:27 GMT 2025` Edited by `admin` on `Mon Mar 31 22:10:27 GMT 2025`
Record UNII	DL609MM5I8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GUAMECYCLINE DIHYDROCHLORIDE

Preferred Name

English

GUAMECYCLINE HYDROCHLORIDE

Common Name

English

2-NAPHTHACENECARBOXAMIDE, N-((4-(((AMINOIMINOMETHYL)AMINO)IMINOMETHYL)-1-PIPERAZINYL)METHYL)-4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,6,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-, HYDROCHLORIDE (1:2), (4S,4AS,5AS,6S,12AS)-

Systematic Name

English

TERRATREX

Brand Name

English

GUAMECYCLINE HCL

Common Name

English

GUAMECYCLINE DIHYDROCHLORIDE [MI]

Common Name

English

NSC-118695

Code

English

XANTHOMYCIN A, HYDROCHLORIDE

Common Name

English

XANTHOCYCLINE

Common Name

English

Guamecycline hydrochloride [WHO-DD]

Common Name

English

Code System Code Type Description

NSC

118695