U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 18:14:08 GMT 2025
Edited
by admin
on Tue Apr 01 18:14:08 GMT 2025
Protein Type ENZYME
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
FMS08T2916
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D
Common Name English
DPDE3
Preferred Name English
PDE43
Common Name English
PDE4D
Common Name English
Code System Code Type Description
UNIPROT
Q08499
Created by admin on Tue Apr 01 18:14:08 GMT 2025 , Edited by admin on Tue Apr 01 18:14:08 GMT 2025
PRIMARY
FDA UNII
FMS08T2916
Created by admin on Tue Apr 01 18:14:08 GMT 2025 , Edited by admin on Tue Apr 01 18:14:08 GMT 2025
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
ALLOSTERIC INHIBITOR->TARGET
Selective negative allosteric modulator with binding affinity values (IC50) of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.
ALLOSTERIC INHIBITOR
INHIBITOR -> TARGET
Catalytic domain
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
RADIOLIGAND->TARGET
INHIBITOR->OFF-TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
PDE4D catalytic domain
IC50

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_142] [1_299] [1_301] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL