Details
| Stereochemistry | MIXED |
| Molecular Formula | C10H16 |
| Molecular Weight | 136.234 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)C2CCC(C2)C1=C
InChI
InChIKey=CRPUJAZIXJMDBK-UHFFFAOYSA-N
InChI=1S/C10H16/c1-7-8-4-5-9(6-8)10(7,2)3/h8-9H,1,4-6H2,2-3H3
| Molecular Formula | C10H16 |
| Molecular Weight | 136.234 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Camphene is a bicyclic monoterpene, a Plant Derived Monoterpene, which possessed antitumor activity. This was found in vivo by inhibiting subcutaneous tumor growth of highly aggressive melanoma cells in a syngeneic model, suggesting a promising role of this compound in cancer therapy. In addition was shown, that camphene lowered cholesterol and triglycerides (TG) in the plasma of hyperlipidemic rats without affecting HMG-CoA reductase activity. And was suggested, that camphene upregulated Sterol regulatory element-binding proteins (SREBP-1) expression and microsomal triglyceride transfer protein (MTP) inhibition was likely to be a probable mechanism whereby camphene exerts its hypolipidemic effect.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P36956|||Q6PJ36 Gene ID: 6720.0 Gene Symbol: SREBF1 Target Organism: Homo sapiens (Human) |
|||
Target ID: P55157 Gene ID: 4547.0 Gene Symbol: MTTP Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Formaldehyde in the indoor environment. | 2010-04-14 |
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| Comparative chemical composition and antiproliferative activity of aerial parts of Salvia leriifolia Benth. and Salvia acetabulosa L. essential oils against human tumor cell in vitro models. | 2010-02 |
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| Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor. | 2010-02 |
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| Rosmarinus officinalis L.: chemical modifications of the essential oil and evaluation of antioxidant and antimicrobial activity. | 2009-12 |
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| Chemical composition of hydrodistilled essential oil of Artemisia incana (L.) Druce and antimicrobial activity against foodborne microorganisms. | 2009-12 |
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| Influence of growth phase and geographic origin on the essential oil composition of Pituranthos chloranthus from Tunisia. | 2009-11 |
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| Multiple ultrafast, broadband 2D NMR spectra of hyperpolarized natural products. | 2009-10-07 |
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| Fingerprint of selected Salvia species by HS-GC-MS analysis of their volatile fraction. | 2009-08 |
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| Temperature-dependent release of volatile organic compounds of eucalypts by direct analysis in real time (DART) mass spectrometry. | 2009-08 |
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| Tissue engineering polymeric microcarriers with macroporous morphology and bone-bioactive surface. | 2009-07-07 |
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| Formation and stability of secondary ozonides from monoterpenes studied by mass spectrometry. | 2009-07 |
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| Composition and seasonal variation of the essential oil from Abies sachalinensis from Hokkaido, Japan. | 2009-06 |
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| Terpenoid emissions from Quercus robur. A case study of Galicia (NW Spain). | 2009-06 |
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| Preparation of porous bioactive ceramic microspheres and in vitro osteoblastic culturing for tissue engineering application. | 2009-06 |
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| Effects of a thiosemicarbazide camphene derivative on Trichophyton mentagrophytes. | 2009-05-13 |
|
| Radical Scavenging Activity of the Essential Oil of Silver Fir (Abies alba). | 2009-05 |
|
| Fumigant and contact toxicities of monoterpenes to Sitophilus oryzae (L.) and Tribolium castaneum (Herbst) and their inhibitory effects on acetylcholinesterase activity. | 2009-05 |
|
| Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method. | 2009-05 |
|
| Comparative analysis of chemical compositions and antimicrobial activities of essential oils from Abies holophylla and Abies koreana activities of essential oils from Abies holophylla and Abies koreana. | 2009-04 |
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| Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts. | 2009-04 |
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| Plant derived antioxidants - Geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. | 2009-03 |
|
| Composition and antibacterial activity of essential oils of Artemisia fragrans Willd. leaves and roots from Iran. | 2009-02 |
|
| Essential oil variability in natural populations of Picea omorika, a rare European conifer. | 2009-02 |
|
| Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC-MS and chemometric resolution methods. | 2009-02 |
|
| In vitro biological activity of Salvia leriifolia benth essential oil relevant to the treatment of Alzheimer's disease. | 2009 |
|
| The oil-dispersion bath in anthroposophic medicine--an integrative review. | 2008-12-04 |
|
| Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata. | 2008-12 |
|
| [Analysis of volatile oil in pre and post processed pieces of Eriobotrya japonica by GC-MS]. | 2008-11 |
|
| [Characterization of chemical components of essential oil from flowers of Chrysanthemum morifolium produced in Anhui province]. | 2008-10 |
|
| The essential oil qualitative and quantitative composition in the needles of Pinus sylvestris L. growing along industrial transects. | 2008-10 |
|
| Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. | 2008-09-25 |
|
| Variability of the needle essential oils of Pinus peuce from different populations in Montenegro and Serbia. | 2008-07 |
|
| Effects of cis-beta-ocimene, cis-sabinene hydrate, and monoterpene and sesquiterpene mixtures on alfalfa pellet intake by lambs. | 2008-06 |
|
| Speedy component resolution: an improved tool for processing diffusion-ordered spectroscopy data. | 2008-05-15 |
|
| Mass propagation and essential oil analysis of Artemisia vulgaris. | 2008-03 |
|
| Chemical composition and antimicrobial activity of essential oil from cones of Pinus koraiensis. | 2008-03 |
|
| Bimolecular and unimolecular contributions to the disparate self-chemical ionizations of alpha-pinene and camphene isomers. | 2007-11 |
|
| Chemical compositions of the essential oils of stems, leaves and flowers of Prangos acaulis (Dc) Bornm. | 2007-08-15 |
|
| Essential oil composition of terminal branches, cones and roots of Tetraclinis articulata from Tunisia. | 2007-08-01 |
|
| Variability of the needle essential oils of Pinus heldreichii from different populations in Montenegro and Serbia. | 2007-05 |
|
| Temperature dependence of the optical rotation in six bicyclic organic molecules calculated by vibrational averaging. | 2007-03-12 |
|
| Volatile chemical constituents of Piper aduncum L and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea. | 2007-03-09 |
|
| Analysis by gas chromatography-mass spectrometry of essential oil from seeds and aerial parts of Ferulago angulata (Schlecht.) Boiss gathered in Nevakoh and Shahoo, Zagross mountain, West of Iran. | 2007-03-01 |
|
| Volatile organic compounds of Angelica gigas Nakai, Korean medicinal herb. | 2007-03 |
|
| Assessment and implications of intraspecific and phenological variability in monoterpenes of Scots pine (Pinus sylvestris) foliage. | 2007-03 |
|
| Plant coexistence alters terpene emission and content of Mediterranean species. | 2007-03 |
|
| Chemical composition of the essential oil of Pelargonium quercetorum Agnew. of Iran. | 2007-01 |
|
| Anticonflict effects of lavender oil and identification of its active constituents. | 2006-12 |
|
| Baseline isotopic data of polyhalogenated compounds. | 2006-09-08 |
|
| Biotransformation of terpenoids by mammals, microorganisms, and plant-cultured cells. | 2005-05 |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment: Camphene induced apoptosis by the intrinsic pathway in melanoma cells mainly by causing endoplasmic reticulum (ER) stress, with release of Ca(2+) together with HmgB1 and calreticulin, loss of mitochondrial membrane potential and up regulation of caspase-3 activity.
Unknown
| Substance Class |
Chemical
Created
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admin
on
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Mon Mar 31 18:42:43 GMT 2025
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| Record UNII |
G3VG94Z26E
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Validated (UNII)
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21 CFR 172.515
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JECFA EVALUATION |
CAMPHENE
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2395761
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900
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CAMPHENE
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| Related Record | Type | Details | ||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Monoterpene Class
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PARENT -> CONSTITUENT MAY BE PRESENT |
