Avatrombopag Maleate

Details

Stereochemistry	ACHIRAL
Molecular Formula	C29H34Cl2N6O3S2.C4H4O4
Molecular Weight	765.727
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.OC(=O)C1CCN(CC1)C2=C(Cl)C=C(C=N2)C(=O)NC3=NC(C4=CC(Cl)=CS4)=C(S3)N5CCN(CC5)C6CCCCC6

InChI

InChIKey=MISPBGHDNZYFNM-BTJKTKAUSA-N

InChI=1S/C29H34Cl2N6O3S2.C4H4O4/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40;5-3(6)1-2-4(7)8/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38);1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	C29H34Cl2N6O3S2
Molecular Weight	649.655
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210238s000lbl.pdf | https://www.fiercepharma.com/pharma/dova-s-oral-platelet-booster-doptelet-approved-by-fda-shionogi-s-rival-closely-behind

Avatrombopag is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist that stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells resulting in increased production of platelets. Avatrombopag does not compete with TPO for binding to the TPO receptor and has an additive effect with TPO on platelet production. Avatrombopag was discovered by Yamanouchi Pharmaceutical, developed by AkaRx which late became acquired by Dova Pharmaceuticals. In 2018 avatrombopag was approved by the FDA for thrombocytopenia in adults with chronic liver disease scheduled to undergo a procedure.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Thrombopoietin receptor 9 Target ID: P40238 Gene ID: 4352.0 Gene Symbol: MPL Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/19183407	Agonist 2752		3.3 nM [EC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Chronic liver disease-associated thrombocytopenia 2 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210238s000lbl.pdf	Primary		Approved 8583	DOPTELET Approved Use Treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure. Launch Date 2018

C_max

Value	Dose	Analyte	Population
95.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
164 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
284 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
117 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
183 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
388 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30203841	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Analyte	Population
3160 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
5900 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
10000 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
3340 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
4840 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10863.5 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30203841	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Analyte	Population
18.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
18 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
18.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/28339166/	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
18 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30203841	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	AVATROMBOPAG plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Doses

Dose	Population	Adverse events
100 mg single, oral Dose: 100 mg Route: oral Route: single Dose: 100 mg Sources: https://pubmed.ncbi.nlm.nih.gov/30203841	healthy, 25.5 years Health Status: healthy Age Group: 25.5 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/30203841	Other AEs: Dysgeusia, Flatulence... Other AEs: Dysgeusia (16.7%) Flatulence (16.7%) Dizziness (16.7%) Headache (16.7%) Diarrhoea (16.7%) Sources: https://pubmed.ncbi.nlm.nih.gov/30203841
40 mg 1 times / day multiple, oral Recommended Dose: 40 mg, 1 times / day Route: oral Route: multiple Dose: 40 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210238s000lbl.pdf	unhealthy, 58 years (range: 19-86 years) Health Status: unhealthy Age Group: 58 years (range: 19-86 years) Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210238s000lbl.pdf	Other AEs: Pyrexia, Abdominal pain... Other AEs: Pyrexia (8%) Abdominal pain (7%) Nausea (7%) Headache (7%) Fatigue (3%) Edema peripheral (4%) Hyponatremia (serious, 8%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210238s000lbl.pdf
60 mg 1 times / day multiple, oral Recommended Dose: 60 mg, 1 times / day Route: oral Route: multiple Dose: 60 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210238s000lbl.pdf	unhealthy, 58 years (range: 19-86 years) Health Status: unhealthy Age Group: 58 years (range: 19-86 years) Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210238s000lbl.pdf	Disc. AE: Anemia, Pyrexia... Other AEs: Pyrexia, Abdominal pain... AEs leading to discontinuation/dose reduction: Anemia (0.4%) Pyrexia (0.4%) Myalgia (0.4%) Other AEs: Pyrexia (11%) Abdominal pain (6%) Nausea (6%) Headache (4%) Fatigue (4%) Edema peripheral (3%) Hyponatremia (serious, 7%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210238s000lbl.pdf
60 mg 1 times / day multiple, oral Recommended Dose: 60 mg, 1 times / day Route: oral Route: multiple Dose: 60 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf	unhealthy, 58 years (range: 19-86 years) Health Status: unhealthy Age Group: 58 years (range: 19-86 years) Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf	Other AEs: Gastrointestinal disorders, General disorders and administration site conditions... Other AEs: Gastrointestinal disorders (25.2%) General disorders and administration site conditions (14.8%) Nervous system disorders (7.8%) Injury, poisoning and procedural complications (2.6%) Infection (9.6%) Infestation (9.6%) Respiratory disorder (8.7%) Thoracic disorders (excl lung and pleura) (8.7%) Mediastinal disorders (8.7%) Musculoskeletal disorder (5.2%) Connective tissue disorders (5.2%) Metabolism disorders NEC (5.2%) General nutrition disorder (5.2%) Skin disorder (1.7%) Skin and subcutaneous tissue disorders (1.7%) Blood disorder (3.5%) Lymphatic system disorders NEC (3.5%) Psychiatric disorders (4.3%) Urinary tract disorder NOS (3.5%) Renal disorder (3.5%) Vascular disorders (0.9%) Hepatobiliary disorders (1.7%) Eye disorders (0.9%) Cardiac disorders (0.9%) Disorder ear (0.9%) Labyrinthine disorders (0.9%) Endocrine disorders (0.9%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf
60 mg 1 times / day multiple, oral Recommended Dose: 60 mg, 1 times / day Route: oral Route: multiple Dose: 60 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf	unhealthy, 58 years (range: 19-86 years) Health Status: unhealthy Age Group: 58 years (range: 19-86 years) Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf	Other AEs: Gastrointestinal disorders, General disorders and administration site conditions... Other AEs: Gastrointestinal disorders (29.6%) General disorders and administration site conditions (23.9%) Nervous system disorders (8.8%) Injury, poisoning and procedural complications (10.1%) Infection (3.1%) Infestation (3.1%) Respiratory disorder (4.4%) Thoracic disorders (excl lung and pleura) (4.4%) Mediastinal disorders (4.4%) Musculoskeletal disorder (6.9%) Connective tissue disorders (6.9%) Metabolism disorders NEC (3.8%) General nutrition disorder (3.8%) Skin disorder (5%) Skin and subcutaneous tissue disorders (5%) Blood disorder (3.8%) Lymphatic system disorders NEC (3.8%) Psychiatric disorders (3.1%) Urinary tract disorder NOS (1.3%) Renal disorder (1.3%) Vascular disorders (2.5%) Hepatobiliary disorders (1.9%) Eye disorders (2.5%) Cardiac disorders (0.6%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf

AEs

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
	substrate 1193 inhibitor 2438 inducer 440	inhibitor 2507	inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
BCRP 910 OAT3 747 CYP1A 70 CYP2B6 926 CYP2C8 1057 CYP2C19 2057 CYP2E1 1060 CYP3A 227 OAT1 725 OCT2 779 OATP1B1 1079 OATP1B3 961	CYP3A 220 P-gp 2052 BCRP 697 OATP1B1 503 OATP1B3 435 OAT1 395 OAT3 391 OCT2 434 MATE1 182 MATE2 98	CYP2C8 198 CYP1A2 832 CYP2B6 669 CYP3A 142

Drug as perpetrator

Target	Modality	Activity
CYP1A 122	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
CYP1A2 2333	inducer 1966 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
CYP2B6 1160	inducer 1966 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
CYP2B6 1160	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
CYP2C19 2141	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
CYP2C8 1117	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
CYP2C9 2497	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
CYP2D6 2546	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
CYP2E1 1146	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
CYP3A 317	inducer 1966 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
CYP3A 317	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
OAT1 730	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
OATP1B1 1095	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
OATP1B3 970	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
OCT2 782	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	no
CYP2C8 1117	inducer 1966 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	weak
CYP2C9 2497	inducer 1966 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	weak
BCRP 985	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	yes
OAT3 749	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=65 Page: 65.0	yes

Drug as victim

Target	Modality	Activity
CYP2C9 1193	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=64 Page: 64.0	major
CYP3A 220	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=64 Page: 64.0	major
BCRP 697	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=67 Page: 67.0	no
MATE1 182	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=67 Page: 67.0	no
MATE2 98	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=67 Page: 67.0	no
OAT1 395	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=67 Page: 67.0	no
OAT3 391	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=67 Page: 67.0	no
OATP1B1 503	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=67 Page: 67.0	no
OATP1B3 435	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=67 Page: 67.0	no
OCT2 434	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=67 Page: 67.0	no
P-gp 2052	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=67 Page: 67.0	yes

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210238Orig1s000MultidisciplineR.pdf#page=36 Page: 36.0

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY561084	https://www.001chemical.com/chem/570406-98-3
AA Blocks	AA00ECCF	https://www.aablocks.com/goods/Goods/detail?id=AA00ECCF
Achemtek	0102-012478	http://www.achemtek.com/570406-98-3
Adooq BioScience	A14087	https://www.adooq.com/avatrombopag.html
Alfa Chemistry	570406-98-3	https://www.alfa-chemistry.com/akr-501-cas-570406-98-3-item-292701.htm
Angene	AGN-PC-0SMVXA	http://www.angenechemical.com/productshow/AGN-PC-0SMVXA.html
BioChemPartner	BCP28031	http://www.biochempartner.com/570406-98-3-BCP28031
Chem Scene	CS-3397	http://www.chemscene.com/570406-98-3.html
Chemspace	CSSS00015191580	https://chem-space.com/CSSS00015191580
Debye Scientific	DB-072238	http://www.debyesci.com/cas_570406-98-3.html
eNovation Chemicals	D672684	https://www.enovationchem.com/ProductDetails.asp?ProductID=D672684
eNovation Chemicals	Y1084033	https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1084033
Finetech	FT-0728753	http://www.finetechnology-ind.com/prod/detail/pub/570406-98-3.html
Lab Network	LN01341838	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01341838
Matrix Scientific	148389	https://www.matrixscientific.com/148389.html
MedChem Express	HY-13463	https://www.medchemexpress.com/avatrombopag.html
Molcore	MC561084	https://www.molcore.com/product/570406-98-3
Selleck Chemicals	S6624	http://www.selleckchem.com/products/avatrombopag.html
Smolecule	S519822	http://www.smolecule.com/products/s519822
Synblock Inc	SB16846	http://www.synblock.com/product/570406-98-3.html
THE BioTek	bt-261048	https://www.thebiotek.com/product/inhibitors/bt-261048

PubMed

Title	Date	PubMed
AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist.	2009-04	19183407
Romiplostim: a second-generation thrombopoietin agonist.	2009-03	19436840
AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis.	2008-10	18619724

Patents

Sample Use Guides

In Vivo Use Guide

For patients with a platelet count 40000 to <50000/mm3: 40 mg once daily for 5 consecutive days, orally. For patients with platelet count below 40,000/mm3: 60 mg once daily for 5 consecutive days.

Route of Administration: Oral

In Vitro Use Guide

Avatrombopag stimulated the proliferation of cells expressing the human thrombopoietin receptor (c-Mpl) with an EC50 value of 3.3 nM and promoted the differentiation of human hematopoietic progenitor cells (cord blood CD34+ cells) to megakaryocytes with an EC50 value of 25.0 nM.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:16:14 GMT 2025` Edited by `admin` on `Mon Mar 31 18:16:14 GMT 2025`
Record UNII	GDW7M2P1IS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Avatrombopag Maleate

Official Name

English

E-5501 MALEATE

Preferred Name

English

AVATROMBOPAG MALEATE [JAN]

Common Name

English

Avatrombopag maleate [WHO-DD]

Common Name

English

AVATROMBOPAG MALEATE [USAN]

Common Name

English

AVATROMBOPAG MALEATE [MI]

Common Name

English

E5501 MALEATE

Code

English

AVATROMBOPAG MALEATE [ORANGE BOOK]

Common Name

English

DOPTELET

Brand Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

699419