Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H12N2O.ClH |
| Molecular Weight | 212.676 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NCCC1=CNC2=C1C=C(O)C=C2
InChI
InChIKey=MDIGAZPGKJFIAH-UHFFFAOYSA-N
InChI=1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C10H12N2O |
| Molecular Weight | 176.2151 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter produced by serotonergic neurons in the CNS and enterochromaffin cells in the gastrointestinal tract. Pharmacologic action of serotonin is mediated by a large and diverse range of 5-HT receptors. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder, and anxiety. It is also believed to be influential on sexuality and appetite. Creatinine is a product of the metabolic breakdown of creatine phosphate in muscle. Creatinine is filtered by healthy kidneys. Serotonin creatinine sulfate complex was the first isolated salt form of serotonin.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Functional reconstitution and characterization of recombinant human alpha 1-glycine receptors. | 2001-06-15 |
|
| Pharmacological characterization of the rat paw edema induced by Bothrops lanceolatus (Fer de lance) venom. | 2001-06 |
|
| Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. | 2001-04-20 |
|
| Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily. | 2001-04-06 |
|
| Peripheral interleukin-6 administration increases extracellular concentrations of serotonin and the evoked release of serotonin in the rat striatum. | 2001-04 |
|
| Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid. | 2001-03-30 |
|
| Presynaptic neuronal antigens expressed by a small cell lung carcinoma cell line. | 2001-02-01 |
|
| Identification of the aromatic L-amino acid decarboxylase (AADC) gene and its expression in the attachment and metamorphosis of the barnacle, Balanus amphitrite. | 2001-02 |
|
| New avenues in treatment of paediatric migraine: a review of the literature. | 2001-02 |
|
| Evidence for a serotonin transporter deficit in experimental acute liver failure. | 2001-02 |
|
| Human platelet calcium mobilisation in response to beta-amyloid (25-35): buffer dependency and unchanged response in Alzheimer's disease. | 2001-02 |
|
| Distribution and chemical coding of orphanin FQ/nociceptin-immunoreactive neurons in the myenteric plexus of guinea pig intestines and sphincter of Oddi. | 2001-01-29 |
|
| Mapping of 5-HT2A receptors and their mRNA in monkey brain: [3H]MDL100,907 autoradiography and in situ hybridization studies. | 2001-01-22 |
|
| Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: a positron emission tomography provocation study. | 2001-01-12 |
|
| Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134). | 2001-01-08 |
|
| Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo. | 2001-01-05 |
|
| M100,907, a selective 5-HT(2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex. | 2001-01-05 |
|
| Alcohol-induced euphoria: exclusion of serotonin. | 2001-01-05 |
|
| Functional effects of corticosterone on 5-HT(1A) and 5-HT(1B) receptor activity in rat brain: in vivo microdialysis studies. | 2001-01-05 |
|
| Alternating rhythmic activity induced by dorsal root stimulation in the neonatal rat spinal cord in vitro. | 2001-01-01 |
|
| Necessity of thromboxane A2 for initiation of platelet-mediated contact sensitivity: dual activation of platelets and vascular endothelial cells. | 2001-01-01 |
|
| Cisapride and dexamethasone in the prevention of delayed emesis after cisplatin administration. | 2001-01 |
|
| Atrial arrhythmia in a woman treated with fluoxetine: is there a causal relationship? | 2001-01 |
|
| Radiosynthesis of [123I]betaCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain. | 2001-01 |
|
| Trimethoprim-sulfamethoxazole and clozapine. | 2001-01 |
|
| Misdiagnosis of schizophrenia for a patient with epilepsy. | 2001-01 |
|
| Antisocial personality - part II. | 2001-01 |
|
| Changes of biogenic amine levels in haemolymph during diapausing and non-diapausing status in Pieris brassicae L. | 2001-01 |
|
| Chronic endothelial dysfunction after oversized coronary balloon angioplasty in pigs: a 12-week follow-up of coronary vasoreactivity in vivo and in vitro. | 2001-01 |
|
| Levels of serotonin receptor 2A higher in suicide victims? | 2001-01 |
|
| Paroxetine in breast milk. | 2001-01 |
|
| A novel augmentation strategy for treating resistant major depression. | 2001-01 |
|
| The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study. | 2001-01 |
|
| Depression among pregnant adolescents: an integrated treatment approach. | 2001-01 |
|
| Ondansetron hydrochloride for the treatment of delirium after coronary artery surgery. | 2001-01 |
|
| Ischemic preconditioning with opening of mitochondrial adenosine triphosphate-sensitive potassium channels or Na/H exchange inhibition: which is the best protective strategy for heart transplants? | 2001-01 |
|
| Role of dorsal raphe neurons in paradoxical sleep generation in the cat: no evidence for a serotonergic mechanism. | 2001-01 |
|
| Prevention of galanin upregulation following neonatal infraorbital nerve transection or attenuation of axoplasmic transport does not rescue central vibrissae-related patterns in the rat. | 2001-01 |
|
| Selective loss of Sertoli cell and germ cell function leads to a disruption in sertoli cell-germ cell communication during aging in the Brown Norway rat. | 2001-01 |
|
| Ondansetron is no more effective than supplemental intraoperative oxygen for prevention of postoperative nausea and vomiting. | 2001-01 |
|
| Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed. | 2001-01 |
|
| Hypothesized treatment for migraines using low doses of tryptophan, niacin, calcium, caffeine, and acetylsalicylic acid. | 2001-01 |
|
| The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines. | 2001-01 |
|
| ANP, BNP, and CNP enhance bradycardic responses to cardiopulmonary chemoreceptor activation in conscious sheep. | 2001-01 |
|
| Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function. | 2001-01 |
|
| A single serotonergic modulatory cell can mediate reinforcement in the withdrawal network of the terrestrial snail. | 2001-01 |
|
| Melatonin potentiates contractile responses to serotonin in isolated porcine coronary arteries. | 2001-01 |
|
| Vasoactive intestinal peptide: cardiovascular effects. | 2001-01 |
|
| New abortive agents for the treatment of migraine. | 2001 |
|
| A clinical trial on a plate? The potential of 384-well format solid phase extraction for high-throughput bioanalysis using liquid chromatography/tandem mass spectrometry. | 2001 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:16:14 GMT 2025
by
admin
on
Mon Mar 31 18:16:14 GMT 2025
|
| Record UNII |
GKN429M9VS
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
160436
Created by
admin on Mon Mar 31 18:16:14 GMT 2025 , Edited by admin on Mon Mar 31 18:16:14 GMT 2025
|
PRIMARY | |||
|
m9871
Created by
admin on Mon Mar 31 18:16:14 GMT 2025 , Edited by admin on Mon Mar 31 18:16:14 GMT 2025
|
PRIMARY | |||
|
DBSALT002615
Created by
admin on Mon Mar 31 18:16:14 GMT 2025 , Edited by admin on Mon Mar 31 18:16:14 GMT 2025
|
PRIMARY | |||
|
GKN429M9VS
Created by
admin on Mon Mar 31 18:16:14 GMT 2025 , Edited by admin on Mon Mar 31 18:16:14 GMT 2025
|
PRIMARY | |||
|
DTXSID80165186
Created by
admin on Mon Mar 31 18:16:14 GMT 2025 , Edited by admin on Mon Mar 31 18:16:14 GMT 2025
|
PRIMARY | |||
|
1356129
Created by
admin on Mon Mar 31 18:16:14 GMT 2025 , Edited by admin on Mon Mar 31 18:16:14 GMT 2025
|
PRIMARY | RxNorm | ||
|
GKN429M9VS
Created by
admin on Mon Mar 31 18:16:14 GMT 2025 , Edited by admin on Mon Mar 31 18:16:14 GMT 2025
|
PRIMARY | |||
|
153-98-0
Created by
admin on Mon Mar 31 18:16:14 GMT 2025 , Edited by admin on Mon Mar 31 18:16:14 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |