HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:42:49 GMT 2025` Edited by `admin` on `Tue Apr 01 16:42:49 GMT 2025`
Protein Type	ENZYME
Protein Sub Type	PHOSPHODIESTERASE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	GLY7G3G72E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A

Common Name

English

PDE9A

Preferred Name

English

Code System Code Type Description

FDA UNII

GLY7G3G72E

Created by admin on Tue Apr 01 16:42:49 GMT 2025 , Edited by admin on Tue Apr 01 16:42:49 GMT 2025

PRIMARY

Related Record Type Details


					O9OC34WOAY

INHIBITOR -> TARGET

Amount:


					H2D2X058MU

SUBSTRATE->ENZYME

Comments:

cGMP specific phosphodiesterase with the highest affinity of all PDEs for cGMP withKm= 170 nM.

Qualification:

Km

Amount:


					W248Y1AKOR

INHIBITOR -> TARGET


					7N969W8Y4O

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_379]	SITE_SPECIFIC			DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL