PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 03:24:47 GMT 2025` Edited by `admin` on `Wed Apr 02 03:24:47 GMT 2025`
Protein Type	PHOSPHATASE
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	HC6J8I9XAO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN

Common Name

English

MMAC1

Preferred Name

English

TEP1

Common Name

English

PHOSPHATASE AND TENSIN HOMOLOG

Common Name

English

PTEN

Common Name

English

MUTATED IN MULTIPLE ADVANCED CANCERS 1

Common Name

English

Code System Code Type Description

UNIPROT

P60484

Created by admin on Wed Apr 02 03:24:47 GMT 2025 , Edited by admin on Wed Apr 02 03:24:47 GMT 2025

PRIMARY

FDA UNII

HC6J8I9XAO

Created by admin on Wed Apr 02 03:24:47 GMT 2025 , Edited by admin on Wed Apr 02 03:24:47 GMT 2025

PRIMARY

PHAROS

P60484

Created by admin on Wed Apr 02 03:24:47 GMT 2025 , Edited by admin on Wed Apr 02 03:24:47 GMT 2025

PRIMARY

Related Record Type Details


					S7U6QTD522

Phosphatidylinositol (3,4,5)-trisphosphate

SUBSTRATE -> METABOLIC ENZYME

Comments:

Acts as a phosphatase to dephosphorylate PIP3 back to PIP2. This removes the membrane-localization factor from the Akt signaling pathway. Without this localization, the rate of Akt1 activation decreases significantly, as do all of the downstream pathways that depend on Akt1 for activation.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_381] [1_382]		T		THREONINE PHOSPHATE	3L4WX7B1EI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL