Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H24N4O3.ClH |
| Molecular Weight | 392.88 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NC1=C(NC\C=C/COC2=CC(CN3CCCCC3)=CC=N2)C(=O)C1=O
InChI
InChIKey=ODBOENMSSFCACZ-PVOKDAACSA-N
InChI=1S/C19H24N4O3.ClH/c20-16-17(19(25)18(16)24)22-7-2-5-11-26-15-12-14(6-8-21-15)13-23-9-3-1-4-10-23;/h2,5-6,8,12,22H,1,3-4,7,9-11,13,20H2;1H/b5-2-;
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C19H24N4O3 |
| Molecular Weight | 356.4189 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
http://www.ncbi.nlm.nih.gov/pubmed/9730007
Curator's Comment: description was created based on several sources, including
http://www.ncbi.nlm.nih.gov/pubmed/9730007
Pibutidine hydrochloride (IT-066), a novel histamine H2 receptor antagonist has powerful and long lasting antisecretory and antiulcer effects and is a useful antisecretory drug for treatment of peptic ulcer diseases.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Determination of pibutidine metabolites in human plasma by LC-MS/MS. | 2000-12-15 |
|
| Effect of pibutidine hydrochloride on nitric oxide production in rat gastric mucosa. | 1998-06 |
|
| Effects of the new H2-receptor antagonist 3-amino-4-[4- [4- (1-piperidinomethyl)-2-pyridyloxy]-cis-2-butenylamino]-3-cyclobutene-1, 2- dione hydrochloride on gastric acid secretion and ulceration. | 1990-01 |
Sample Use Guides
oral administration of a 20-mg dose of pibutidine hydrochloride
Route of Administration:
Oral
When H2-receptor transfected cells were treated with IT-066 (PIBUTIDINE) for 30 min, the inhibitory effect of IT-066 on the [3H]tiotidine binding still remained even after the cells were extensively washed. Scatchard plot analysis supported the non-competitive and irreversible action of IT-066. When the canine mutated H2-receptor-expressed cells were used, which have substituted amino acid of 190Alanine (Ala; position: 190th amino acid) for 190Threonine (Thr) in the fifth transmembrane domain, IT-066 also inhibited [3H]tiotidine binding to the cells concentration-dependently.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:41:47 GMT 2025
by
admin
on
Mon Mar 31 21:41:47 GMT 2025
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| Record UNII |
IF88DF5F6V
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| Record Status |
Validated (UNII)
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126463-66-9
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5282449
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IF88DF5F6V
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admin on Mon Mar 31 21:41:47 GMT 2025 , Edited by admin on Mon Mar 31 21:41:47 GMT 2025
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