U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 18:22:09 GMT 2025
Edited
by admin
on Tue Apr 01 18:22:09 GMT 2025
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
KE3XSX7XYP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MC4-R
Preferred Name English
MELANOCORTIN RECEPTOR 4
Common Name English
MC4R
Common Name English
Code System Code Type Description
FDA UNII
KE3XSX7XYP
Created by admin on Tue Apr 01 18:22:09 GMT 2025 , Edited by admin on Tue Apr 01 18:22:09 GMT 2025
PRIMARY
UNIPROT
P32245
Created by admin on Tue Apr 01 18:22:09 GMT 2025 , Edited by admin on Tue Apr 01 18:22:09 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_3
N 1_17
N 1_26
Related Record Type Details
AGONIST->OFF-TARGET
Emax 87 at 10 micromolar
EC50
INHIBITOR -> TARGET
AGONIST -> TARGET
Sexual effects are thought to be related to its ability to activate the MC4 receptor (though the MC3 is thought to also possibly be involved).
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
Binding Assay
INHIBITOR -> TARGET
BINDING
Ki
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL