BENZAMIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H8N2
Molecular Weight	120.1518
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=N)C1=CC=CC=C1

InChI

InChIKey=PXXJHWLDUBFPOL-UHFFFAOYSA-N

InChI=1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)

HIDE SMILES / InChI

Molecular Formula	C7H8N2
Molecular Weight	120.1518
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.	2004-04-02	14726520
Collagen degradation by host-derived enzymes during aging.	2004-03	14981122
Site-directed mutagenesis at the human B2 receptor and molecular modelling to define the pharmacophore of non-peptide bradykinin receptor antagonists.	2004-02-15	14757160
Understanding protein-ligand interactions: the price of protein flexibility.	2004-01-30	14729347
Protein interaction networks by proteome peptide scanning.	2004-01	14737190
Cloning and characterization of a transmembrane-type serine protease from rat kidney, a new sodium channel activator.	2003-12-13	14669991
Characterization of a trypsin-like serine protease of activated B cells mediating the cleavage of surface proteins.	2003-12-05	14642814
Synthesis of L-ascorbic acid in the phloem.	2003-11-24	14633288
[Preparation of high-purity and safe autologous plasmin and its clinical application].	2003-11	14661545
Multinuclear magnetic resonance and theoretical calculations in the study of structure and tautomerism of some 2-amino-N'-(aryl)-benzamidines.	2003-11	14583289
Type III secretion proteins PcrV and PcrG from Pseudomonas aeruginosa form a 1:1 complex through high affinity interactions.	2003-10-18	14565848
Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants.	2003-10-09	14521405
CD26/dipeptidyl peptidase IV enhances expression of topoisomerase II alpha and sensitivity to apoptosis induced by topoisomerase II inhibitors.	2003-10-06	14520473
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis.	2003-09-01	12942121
Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors.	2003-09	12956943
Molecular cloning of trypsin-like cDNAs and comparison of proteinase activities in the salivary glands and gut of the tarnished plant bug Lygus lineolaris (Heteroptera: Miridae).	2003-09	12915180
[Purification and characterization of the fibrinolytic enzyme from Agkistrodon halys halys venom].	2003-08-15	12916236
Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide.	2003-08-14	12904065
Novel oxidative alpha-tosyloxylation of alcohols with iodosylbenzene and p-toluenesulfonic acid and its synthetic use for direct preparation of heteroaromatics.	2003-08-08	12895080
Engineering the primary substrate specificity of Streptomyces griseus trypsin.	2003-08-05	12885239
Design and synthesis of highly constrained factor Xa inhibitors: amidine-substituted bis(benzoyl)--diazepan-2-ones and bis(benzylidene)-bis(gem-dimethyl)cycloketones.	2003-08-05	12878132
Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro.	2003-06-16	12799645
Characterisation of integrin-linked kinase signalling in sporadic human colon cancer.	2003-06-02	12771992
Inhibition of purified factor Xa amidolytic activity may not be predictive of inhibition of in vivo thrombosis: implications for identification of therapeutically active inhibitors.	2003-06-01	12750119
Discovery of 3-amino-4-chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library.	2003-05-19	12729667
Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids.	2003-05-08	12723948
A role for BRCA1 in sporadic breast cancer.	2003-04-22	12698194
Steroid-induced polycystic ovaries in rats: effect of electro-acupuncture on concentrations of endothelin-1 and nerve growth factor (NGF), and expression of NGF mRNA in the ovaries, the adrenal glands, and the central nervous system.	2003-04-08	12725645
Identification and partial characterization of two inducible gelatin-cleavage activities localized to the sea urchin extraembryonic matrix, the hyaline layer.	2003-04-07	12667612
Purification, properties and substrate specificity of a digestive trypsin from Periplaneta americana (Dictyoptera) adults.	2003-04	12650689
Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors.	2003-03-24	12643903
Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.	2003-02-27	12593649
Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors.	2003-02-10	12569391
Nonbenzamidine tetrazole derivatives as factor Xa inhibitors.	2003-02-10	12565931
A novel influenza A virus activating enzyme from porcine lung: purification and characterization.	2003-02	12675514
Reconstructing the binding site of factor Xa in trypsin reveals ligand-induced structural plasticity.	2003-01-31	12527302
Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.	2003-01-31	12441343
Disruption of vitellogenin gene function in adult honeybees by intra-abdominal injection of double-stranded RNA.	2003-01-20	12546706
Purification and partial characterization of feline classical pancreatic lipase.	2003-01	12524043
Inhibitors of benzamidine type influence the virulence properties of Porphyromonas gingivalis strains.	2003	14515152
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.	2003	14511394
The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells.	2002-12-16	12485466
Pattern recognition and massively distributed computing.	2002-12	12395423
Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency.	2002-11-20	12437105
Thrombin inhibition by novel benzamidine derivatives: a free-energy perturbation study.	2002-11-07	12408710
Identification, characterization, and cloning of an immunoglobulin degrading enzyme in the cat flea, Ctenocephalides felis.	2002-11	12386841
Mutant K-ras oncogene regulates steroidogenesis of normal human adrenocortical cells by the RAF-MEK-MAPK pathway.	2002-10-21	12434292
Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum.	2002-10-07	12366865
The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator.	2002-10-02	12361483
Development and validation of a capillary electrophoresis method for ximelagatran assay and related substance determination in drug substance and tablets.	2002-01-15	11755759

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:11:03 GMT 2025` Edited by `admin` on `Mon Mar 31 19:11:03 GMT 2025`
Record UNII	KUE3ZY3J1F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-243704

Preferred Name

English

BENZAMIDINE

Systematic Name

English

BENZENECARBOXIMIDAMIDE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID8045012