MAGNESIUM MALATE

US Approved OTC

First marketed in 1921

Details

Stereochemistry	RACEMIC
Molecular Formula	C4H4O5.Mg
Molecular Weight	156.3766
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Mg++].OC(CC([O-])=O)C([O-])=O

InChI

InChIKey=JFQQIWNDAXACSR-UHFFFAOYSA-L

InChI=1S/C4H6O5.Mg/c5-2(4(8)9)1-3(6)7;/h2,5H,1H2,(H,6,7)(H,8,9);/q;+2/p-2

HIDE SMILES / InChI

Molecular Formula	C4H4O5
Molecular Weight	132.0716
Charge	-2
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	Mg
Molecular Weight	24.305
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/dosage/magnesium-lactate.htmlhttps://www.scbt.com/scbt/product/magnesium-nitrate-hexahydrate-13446-18-9 | https://www.ncbi.nlm.nih.gov/pubmed/18964415 | https://www.ncbi.nlm.nih.gov/pubmed/2843308http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2013.3444/pdfhttps://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdfhttp://www.sciencedirect.com/science/article/pii/004484868990080Xhttps://www.ncbi.nlm.nih.gov/pubmed/351265https://www.drugs.com/ppa/magnesium-chloride.htmlhttp://www.db-pharma.com/anglais/49.pdfhttps://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1http://dx.doi.org/10.1155/2015/498932 | http://iicbe.org/upload/4152C514072.pdfdoi: 10.1081/SCC-120022479DOI: 10.2903/j.efsa.2008.883https://www.ncbi.nlm.nih.gov/pubmed/15480451 | https://www.scbt.com/scbt/product/magnesium-iodide-10377-58-9http://www.internationalcrystal.net/optics_11.htm | https://www.ncbi.nlm.nih.gov/pubmed/27792982 | https://www.ncbi.nlm.nih.gov/pubmed/26952467 | https://www.ncbi.nlm.nih.gov/pubmed/27995243https://hazmap.nlm.nih.gov/category-details?table=copytblagents&id=1640
Curator's Comment: description was created based on several sources, including: https://www.blackmores.com.au/products/magmin | https://www.ncbi.nlm.nih.gov/pubmed/25262412 |http://www.webstercare.com.au/files/continuing_education/wc_continuing_edu_dec2011.pdf

Magnesium diamide is used as a chemical intermediate. Magnesium diamide is spontaneously combustible. It is toxic by inhalation. Skin or eye contact may cause severe burns.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
action potential 66 Target ID: GO:0001508 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12225296	Inhibitor 8504
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: http://www.webstercare.com.au/files/continuing_education/wc_continuing_edu_dec2011.pdf \| https://www.ncbi.nlm.nih.gov/pubmed/26812001	Modulator 846
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: http://www.webmd.com/drugs/2/drug-10702-5106/magnesium-dr/details	Modulator 846
oxalate metabolic process 66 Target ID: GO:0033609 Sources: https://www.medicinep.com/epimag-for-cases-of-oxaluria-and-mild-laxative-to-relieve-constipation-2918.html	Modulator 846
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1	Modulator 846
magnesium ion homeostasis 70 Target ID: GO:0010960 Sources: https://www.standardprocess.com/Products/Standard-Process/Magnesium-Lactate#.WP-FxUXyizc \| https://www.drugs.com/mtm/magnesium-lactate.html	Interacts 323
Protein S100-A8 66 Target ID: P05109 Gene ID: 6279.0 Gene Symbol: S100A8 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8061680	Binding Agent 1076

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2596
Unknown 2596
Bone disease 70 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27792982	Primary	Basic research	Unknown Approved Use Unknown
Bacterial infections 235 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27995243	Primary	Preclinical	Unknown Approved Use Unknown
Bronchial spasm 78 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20647692	Primary	Preclinical	Unknown Approved Use Unknown
Unknown 2596
Unknown 2596
Unknown 2596
Preeclampsia 85 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdf	Preventing	Approved 8583	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 1995
Eclampsia 69 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020309s028lbl.pdf	Primary	Approved 8583	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 1995
Preparation for colonoscopy 66 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/204553s001lbl.pdf	Diagnostic	Approved 8583	ColPrep Kit Approved Use INDICATIONS AND USAGE ColPrep Kit is indicated for cleansing of the colon as a preparation for colonoscopy in adults Launch Date 2016
Atrial fibrillation 131 Sources: https://clinicaltrials.gov/ct2/show/NCT00965874	Primary	Phase III 665	MAGNESIUM SULFATE Approved Use INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose. Launch Date 1995
Unknown 2596
Magnesium deficiency 67 Sources: https://www.blackmores.com.au/products/magmin	Curative	Approved 8583	MagMin Approved Use Magnesium aspartate (MagMin) is indicated for patients with documented hypomagnesaemia.
Unknown 2596
Magnesium deficiency 67 Sources: http://www.db-pharma.com/anglais/49.pdf	Curative	Not Provided 511	DELBIASE Approved Use Unknown
Eclampsia 69 Sources: http://www.medicatione.com/?c=drug&s=delbiase&ingredient=magnesium%20bromide/magnesium%20chloride	Primary	Not Provided 511	DELBIASE Approved Use Unknown
Convulsions 72 Sources: http://www.medicatione.com/?c=drug&s=delbiase&ingredient=magnesium%20bromide/magnesium%20chloride	Primary	Not Provided 511	DELBIASE Approved Use Unknown
Magnesium deficiency 67 Sources: http://www.meritpharm.com/wp-content/uploads/2014/03/Chloromag.Magnesium-Chloride.MSDS_.pdf	Curative	Approved 8583	Magnesium Chloride Approved Use Magnesium Chloride injection is indicated as an electrolyte replenisher in magnesium deficiencies
Fibromyalgia 90 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26343101	Palliative	Phase II 1147	Magnesium Chloride Approved Use Unknown
Stroke 144 Sources: https://clinicaltrials.gov/ct2/show/NCT00933868	Palliative	Phase III 665	Magnesium Chloride Approved Use Unknown
Oxaluria 66 Sources: http://drugpamphlet.blogspot.ru/2012/04/epimag.html	Primary	Approved 8583	EPIMAG Approved Use Magnesium citrate is indicated in cases of oxaluria, to prevent recurrence of calcium oxalate kidney stones.
Constipation 112 Sources: http://drugpamphlet.blogspot.ru/2012/04/epimag.html	Primary	Approved 8583	EPIMAG Approved Use Used to relief of occasional constipation (irregularity).
Magnesium deficiency 67 Sources: https://www.xymogen.com/assets/imageDisplay.ashx?productID=111&attachmentTypeID=1	Curative	Approved 8583	Magnesium Citrate Approved Use Magnesium citrate is indicated to supports magnesium nutritional adequacy.
Unknown 2596
Magnesium deficiency 67 Sources: https://www.standardprocess.com/Products/Standard-Process/Magnesium-Lactate#.WP-FxUXyizc https://www.drugs.com/mtm/magnesium-lactate.html	Curative	Approved 8583	Unknown Approved Use Magnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency.

PubMed

Title	Date	PubMed
Antenatal Exposure to Magnesium Sulfate and Spontaneous Intestinal Perforation and Necrotizing Enterocolitis in Extremely Preterm Neonates.	2017-10	28494498
Fast sono assisted ferrofluid mediated silver super - Adsorption over magnesium ferrite-copper sulfide chalcogenide with the aid of multivariate optimization.	2017-07	28427663
Effect of power ultrasound on crystallization characteristics of magnesium ammonium phosphate.	2017-05	28069191
Magnesium lactate in the treatment of Gitelman syndrome: patient-reported outcomes.	2017-03-01	26940126
Superiority of a Split-dose Regimen of Sodium Picosulfate/Magnesium Citrate (SPMC) in Comparison to a Prior-day Schedule (AM/PM) for Colonoscopy Preparation. A Randomized Single-blinded Study.	2016-09	27689192
Preparation and optimization of a drug delivery system based on berberine chloride-immobilized MgAl hydrotalcite.	2016-06-15	27109050
Polyethylene glycol plus ascorbic acid is as effective as sodium picosulfate with magnesium citrate for bowel preparation: A randomized trial.	2016-04	26945825
Micronized Organic Magnesium Salts Enhance Opioid Analgesia in Rats.	2016	27792736
Single-day sodium picosulfate and magnesium citrate versus split-dose polyethylene glycol for bowel cleansing prior to colonoscopy: A prospective randomized endoscopist-blinded trial.	2015-11	25968966
Randomized controlled trial of low-volume bowel preparation agents for colonic bowel preparation: 2-L polyethylene glycol with ascorbic acid versus sodium picosulfate with magnesium citrate.	2015-02	25410648
A comparison of oral sulfate solution with sodium picosulfate: magnesium citrate in split doses as bowel preparation for colonoscopy.	2014-12	25028274
No effect of magnesium supplementation on metabolic control and insulin sensitivity in type 2 diabetic patients with normomagnesemia.	2014-09-10	25204013
Precipitation of amorphous magnesium ammonium phosphate: is it a precursor for staghorn stones?	2014-06	24643665
Effects of three kinds of organic acids on phosphorus recovery by magnesium ammonium phosphate (MAP) crystallization from synthetic swine wastewater.	2014-04	24296029
[The effectiveness of certain magnesium salts in nephrolithiasis caused by the use of sodium oxalate and celecoxib].	2013-05-14	23662491
Effect of magnesium lactate dihydrate and calcium lactate monohydrate on 20-km cycling time trial performance.	2012-04	22398820
Magnesium chloride tetrahydrate, MgCl2·4H2O.	2012-01	22223272
Increased expression of glucose transporter 3 in gerbil brains following magnesium sulfate treatment and focal cerebral ischemic injury.	2010-06	20517896
Intradermal administration of magnesium sulphate and magnesium chloride produces hypesthesia to mechanical but hyperalgesia to heat stimuli in humans.	2009-08-28	19715604
Formation of formal disilene fluoride adducts.	2008-12-24	19053480
An evaluation of the impact of oral magnesium lactate on the corrected QT interval of patients receiving sotalol or dofetilide to prevent atrial or ventricular tachyarrhythmia recurrence.	2006-04	16630091
Synthesis of a non-heme template for attaching four peptides: an approach to artificial iron(II)-containing peroxidases.	2004-01-23	14725436
Magnesium bromide mediated highly diastereoselective heterogeneous hydrogenation of olefins.	2002-04-18	11950359
Oral magnesium load test in patients with migraine.	2002-02	12005285
Bioavailability of US commercial magnesium preparations.	2001-12	11794633
Trifluoromethanesulfonic anhydride-promoted alpha-bromination of ketones with grignard reagent or magnesium bromide.	2000-12	11145159
An efficient chiral moderator prepared from inexpensive (+)-3-carene: synthesis of the HIV-1 non-nucleoside reverse transcriptase inhibitor DPC 963.	2000-10-05	11009360
Effect of chronic magnesium supplementation on magnesium distribution in healthy volunteers evaluated by 31P-NMRS and ion selective electrodes.	1999-11	10594466
Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery.	1999-10	10552215
Struvite stones.	1999	9873215
Magnesium supplementation in patients with congestive heart failure.	1997-02	9013430
Conventional and Eccentric Uses of Crystallographic Databases in Practical Materials Identification Problems.	1996-01-01	27805165
Inhibition of mouse-killing behaviour in magnesium-deficient rats: effect of pharmacological doses of magnesium pidolate, magnesium aspartate, magnesium lactate, magnesium gluconate and magnesium chloride.	1995-03	7669506
Effect of pyridoxine and magnesium on stress-induced gastric ulcers in mice selected for low or high blood magnesium levels.	1995	8585697
Magnesium sulfate in the treatment of ventricular arrhythmias due to digoxin toxicity.	1995	7837314
A prospective randomized trial of intravenous magnesium versus intravenous propranolol in acute myocardial infarction.	1994-12	7786689
Accidental cardiopulmonary arrest following magnesium sulphate overdose.	1994-06-15	7958154
Management of eclampsia.	1994-04	8066475
Oral versus intravenous magnesium supplementation in patients with magnesium deficiency.	1991-01-01	1814318
Magnesium and its combination with cinnarizine in the long-term treatment of headache.	1991	1840336
Osteoporosis treated with magnesium lactate.	1991	1837680
Fluorimetry of selenium in body fluids after digestion with nitric acid, magnesium nitrate hexahydrate, and hydrochloric acid.	1988-09	2843308
A comparison of two digestion procedures for the determination of selenium in biological material.	1987-10	18964415
Metabolism of magnesium and zinc in patients treated with antiepileptic drugs and with magnesium lactate.	1987	3129621
Effects of the intravenous administration of magnesium sulfate on corrected serum calcium level and nephrogenous cyclic AMP excretion in normal human subjects.	1986-11	3028586
Hypomagnesaemic tetany associated with prolonged treatment with aminoglycosides.	1986-03-22	3082455
[Inhibitory effect of magnesium on the vocalization and fighting of cats treated with carbachol and eserine].	1982	6215091
Cardiopulmonary arrest due to acute maternal hypermagnesaemia.	1981-05-09	6112438
Struvite stones.	1978-05	351265
Metabolic effects of prolonged intravenous administration of magnesium lactate to the normal human.	1958-09-23	13588556

Patents

Sample Use Guides

In Vivo Use Guide

Magnesium lactate is used as a dietary supplement (200-400 mg of elemental magnesium per day for adults).

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:41:49 GMT 2025` Edited by `admin` on `Mon Mar 31 18:41:49 GMT 2025`
Record UNII	LA9X9UJA2Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MAGNESIUM MALATE

Systematic Name

English

BUTANEDIOIC ACID, 2-HYDROXY-, MAGNESIUM SALT (1:1)

Preferred Name

English

MAGNESIUM MALATE, (±)-

Systematic Name

English

(±)-MAGNESIUM MALATE

Systematic Name

English

Magnesium malate [WHO-DD]

Common Name

English

Classification Tree Code System Code

DSLD

2466 (Number of products:54)