NEPRILYSIN

Possibly Marketed Outside US

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:49:17 GMT 2025` Edited by `admin` on `Tue Apr 01 16:49:17 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	MH8LWM8ARN
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NEPRILYSIN

Common Name

English

ATRIOPEPTIDASE

Preferred Name

English

NEUTRAL ENDOPEPTIDASE 24.11

Common Name

English

COMMON ACUTE LYMPHOCYTIC LEUKEMIA ANTIGEN

Common Name

English

SFE

Common Name

English

CALLA

Common Name

English

CD10

Common Name

English

SKIN FIBROBLAST ELASTASE

Common Name

English

NEUTRAL ENDOPEPTIDASE

Common Name

English

CD_ANTIGEN: CD10

Common Name

English

ENKEPHALINASE

Common Name

English

Code System Code Type Description

SMS_ID

300000013384

Created by admin on Tue Apr 01 16:49:17 GMT 2025 , Edited by admin on Tue Apr 01 16:49:17 GMT 2025

PRIMARY

CAS

82707-54-8

Created by admin on Tue Apr 01 16:49:17 GMT 2025 , Edited by admin on Tue Apr 01 16:49:17 GMT 2025

PRIMARY

FDA UNII

MH8LWM8ARN

Created by admin on Tue Apr 01 16:49:17 GMT 2025 , Edited by admin on Tue Apr 01 16:49:17 GMT 2025

PRIMARY

PHAROS

P08473

Created by admin on Tue Apr 01 16:49:17 GMT 2025 , Edited by admin on Tue Apr 01 16:49:17 GMT 2025

PRIMARY

From	To
1_56	1_61
1_79	1_734
1_87	1_694
1_142	1_410
1_233	1_241
1_620	1_746

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_144
N	1_284
N	1_324
N	1_627

Related Record Type Details


					36NLI90E7T

OMAPATRILAT

INHIBITOR -> TARGET


					5N1YAP5FCM

ILEPATRIL

INHIBITOR -> TARGET


					MU9089C77W

GEMOPATRILAT

INHIBITOR -> TARGET


					M6C2Z58GB9

PL-265

INHIBITOR -> TARGET

Amount:


					KKV299446X

DAGLUTRIL

INHIBITOR -> TARGET


					0N48AL0PRA

FASIDOTRILAT

INHIBITOR -> TARGET

Amount:


					SPI5PBF81S

SACUBITRILAT

INHIBITOR -> TARGET

Amount:


					V7O29949TG

SAMPATRILAT

INHIBITOR -> TARGET

Amount:


					JV29CG9MQ2

UK-414495

INHIBITOR -> TARGET


					XSU5NAK4KT

N-(2-(MERCAPTOMETHYL)-1-OXO-3-PHENYLPROPYL)-L-PHENYLALANINE

INHIBITOR -> TARGET

Amount:


					NPZ6DEL9XZ

N-(2-(Mercaptomethyl)-3-Phenylbutanoyl)-L-Alanine

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					227MQ6QL9D

PL-265 active metabolite

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					V70CKN90GA

KC-12615

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_3] [1_5]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL