U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C30H45NO7P.Na
Molecular Weight 585.6443
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FOSINOPRIL SODIUM

SMILES

[Na+].CCC(=O)O[C@@H](O[P@](=O)(CCCCC1=CC=CC=C1)CC(=O)N2C[C@@H](C[C@H]2C([O-])=O)C3CCCCC3)C(C)C

InChI

InChIKey=TVTJZMHAIQQZTL-WATAJHSMSA-M
InChI=1S/C30H46NO7P.Na/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24;/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35);/q;+1/p-1/t25-,26+,30+,39-;/m1./s1

HIDE SMILES / InChI
Molecular Formula C30H45NO7P
Molecular Weight 562.6546
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
123738
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:24:04 UTC 2023
Edited
by admin
on Fri Dec 15 15:24:04 UTC 2023
Record UNII
NW2RTH6T2N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FOSINOPRIL SODIUM
EP   MART.   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
USAN  
Official Name English
FOSINOPRIL SODIUM SALT [MI]
Common Name English
FOSINOPRIL SODIUM [VANDF]
Common Name English
MONOPRIL
Brand Name English
(4S)-4-CYCLOHEXYL-1-((R)-((S)-1-HYDROXY-2-METHYLPROPOXY)(4-PHENYLBUTYL)PHOSPHINYL)ACETYL-L-PROLINE PROPIONATE (ESTER), SODIUM SALT
Common Name English
FOSINOPRIL SODIUM SALT
MI  
Common Name English
Fosinopril sodium [WHO-DD]
Common Name English
FOSINOPRIL SODIUM COMPONENT OF MONOPRIL HCT
Common Name English
SQ 28555
Code English
FOSINOPRIL SODIUM [EP MONOGRAPH]
Common Name English
FOSINOPRIL SODIUM [USAN]
Common Name English
FOSINOPRIL SODIUM [USP MONOGRAPH]
Common Name English
FOSINOPRIL SODIUM [MART.]
Common Name English
SQ-28555
Code English
MONOPRIL HCT COMPONENT FOSINOPRIL SODIUM
Common Name English
FOSINOPRIL SODIUM [USP-RS]
Common Name English
L-PROLINE, 4-CYCLOHEXYL-1-(((2-METHYL-1-(1-OXOPROPOXY)PROPOXY)(4-PHENYLBUTYL)PHOSPHINYL)ACETYL)-, SODIUM SALT, (1(S*(R*)),2.ALPHA.,4.BETA.)-
Common Name English
FOSINOPRIL SODIUM [USP IMPURITY]
Common Name English
FOSINOPRIL SODIUM [ORANGE BOOK]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C247
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL3039598
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
FDA UNII
NW2RTH6T2N
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
USAN
W-66
Created by admin on Fri Dec 15 15:24:05 UTC 2023 , Edited by admin on Fri Dec 15 15:24:05 UTC 2023
PRIMARY
MERCK INDEX
m5553
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY Merck Index
DAILYMED
NW2RTH6T2N
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
EVMPD
SUB02265MIG
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
PUBCHEM
49800050
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
CAS
88889-14-9
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
RXCUI
227278
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY RxNorm
CHEBI
5164
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
DRUG BANK
DBSALT000193
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
NCI_THESAURUS
C47542
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
EPA CompTox
DTXSID7046621
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
RS_ITEM_NUM
1283404
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
SMS_ID
100000092343
Created by admin on Fri Dec 15 15:24:04 UTC 2023 , Edited by admin on Fri Dec 15 15:24:04 UTC 2023
PRIMARY
Related Record Type Details
Structure of FOSINOPRIL
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of (2S,4R)-4-CYCLOHEXYL-1-(((R)-((1S)-2-METHYL-1-(1-OXOPROPOXY)PROPOXY)(4-PHENYLBUTYL)PHOSPHORYL)ACETYL)PYRROLIDINE-2-CARBOXYLIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of (2S,4S)-4-CYCLOHEXYL-1-(((SR)-((1SR)-2-METHYL-1-(1-OXOPROPOXY)PROPOXY)(4-PHENYLBUTYL)PHOSPHORYL)ACETYL)PYRROLIDINE-2-CARBOXYLIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of (2R,4S)-4-CYCLOHEXYL-1-(((R)-((1S)-2-METHYL-1-(1-OXOPROPOXY)PROPOXY)(4-PHENYLBUTYL)PHOSPHORYL)ACETYL)PYRROLIDINE-2-CARBOXYLIC ACID
IMPURITY -> PARENT
sum of impurities B, E and H: not more than 10 times the area of the principal peak in the chromatogram obtained with reference solution (b) (1.0 per cent.)
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of (2S,4S)-4-CYCLOHEXYL-1-(((R)-(4-PHENYLBUTYL)((1S)-1-(1-OXOPROPOXY)PROPOXY)PHOSPHORYL)ACETYL)PYRROLIDINE-2-CARBOXYLIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of (2S,4S)-4-CYCLOHEXYL-1-PIVALOYLPYRROLIDINE-2-CARBOXYLIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 2-((2-METHYL-1-(PROPIONYLOXY)PROPOXY)(4-PHENYLBUTYL)PHOSPHORYL)ACETIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of PHENYLFOSINOPRIL
IMPURITY -> PARENT
sum of impurities B, E and H: not more than 10 times the area of the principal peak in the chromatogram obtained with reference solution (b) (1.0 per cent)
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of (2S,4S)-4-CYCLOHEXYL-1-(((2S,4S)-4-CYCLOHEXYL-1-(((R)-((1S)-2-METHYL-1-(1-OXOPROPOXY)PROPOXY)(4-PHENYLBUTYL)PHOSPHORYL)ACETYL)PYRROLIDIN-2-YL)CARBONYL)PYRROLIDINE-2-CARBOXYLIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of FOSINOPRILAT
IMPURITY -> PARENT
Structure of 2-[(R)-[(1S)-2-Methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetic acid, rel-
IMPURITY -> PARENT
Structure of (2RS,4RS)-4-CYCLOHEXYL-1-(((RS)-((1SR)-2-METHYL-1-(1-OXOPROPOXY)PROPOXY)(4-PHENYLBUTYL)PHOSPHORYL)ACETYL)PYRROLIDINE-2-CARBOXYLIC ACID
IMPURITY -> PARENT
sum of impurities B, E and H: not more than 10 times the area of the principal peak in the chromatogram obtained with reference solution (b) (1.0 per cent)
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of (S)-4-CYCLOHEXYL-1-(3-OXOPENTANOYL)-L-PROLINE
IMPURITY -> PARENT
if present
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Related Record Type Details
Structure of FOSINOPRILAT
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966