N-DESMETHYLTAMOXIFEN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H27NO
Molecular Weight	357.488
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC\C(=C(/C1=CC=CC=C1)C2=CC=C(OCCNC)C=C2)C3=CC=CC=C3

InChI

InChIKey=NYDCDZSEEAUOHN-IZHYLOQSSA-N

InChI=1S/C25H27NO/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2/h4-17,26H,3,18-19H2,1-2H3/b25-24-

HIDE SMILES / InChI

Molecular Formula	C25H27NO
Molecular Weight	357.488
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells.	2009-03-01	19244106
Association of tamoxifen (TAM) and TAM metabolite concentrations with self-reported side effects of TAM in women with breast cancer.	2004-05	15039600
Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.	2003-12-03	14652237
Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites.	2002-10	12419016
Peroxidase activation of tamoxifen and toremifene resulting in DNA damage and covalently bound protein adducts.	1995-03	7697811

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:38:30 GMT 2025` Edited by `admin` on `Mon Mar 31 19:38:30 GMT 2025`
Record UNII	OOJ759O35C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-DESMETHYLTAMOXIFEN

Common Name

English

ICI-55548

Preferred Name

English

2-(4-((Z)-1,2-DIPHENYLBUT-1-ENYL)PHENOXY)-N-METHYLETHANAMINE

Systematic Name

English

DEMETHYLTAMOXIFEN

Common Name

English

ETHANAMINE, 2-(4-((1Z)-1,2-DIPHENYL-1-BUTEN-1-YL)PHENOXY)-N-METHYL-

Systematic Name

English

DESMETHYLTAMOXIFEN

Common Name

English

TAMOXIFEN CITRATE IMPURITY F [EP IMPURITY]

Common Name

English

DESMETHYLTAMOXIFEN, N-

Common Name

English

N-DEMETHYLTAMOXIFEN

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2163