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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 19:16:34 GMT 2025
Edited
by admin
on Tue Apr 01 19:16:34 GMT 2025
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
P6W5IXV8V9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLUA2
Preferred Name English
AMPA-SELECTIVE GLUTAMATE RECEPTOR 2
Common Name English
AMPAR (GLUR-2)4
Common Name English
GLUR-K2
Common Name English
GLUR-B
Common Name English
GLUR2
Common Name English
GLUR-2
Common Name English
GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2
Common Name English
GLUTAMATE RECEPTOR 2
Common Name English
Code System Code Type Description
FDA UNII
P6W5IXV8V9
Created by admin on Tue Apr 01 19:16:34 GMT 2025 , Edited by admin on Tue Apr 01 19:16:34 GMT 2025
PRIMARY
UNIPROT
P42262
Created by admin on Tue Apr 01 19:16:34 GMT 2025 , Edited by admin on Tue Apr 01 19:16:34 GMT 2025
PRIMARY
PHAROS
P42262
Created by admin on Tue Apr 01 19:16:34 GMT 2025 , Edited by admin on Tue Apr 01 19:16:34 GMT 2025
PRIMARY
From To
1_54 1_306
4_54 4_306
2_54 2_306
3_54 3_306
1_715 1_770
4_715 4_770
2_715 2_770
3_715 3_770
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_232
N 1_346
N 1_382
N 1_389
N 2_232
N 2_346
N 2_382
N 2_389
N 3_232
N 3_346
N 3_382
N 3_389
N 4_232
N 4_346
N 4_382
N 4_389
Related Record Type Details
Structure of Glutamic Acid
AGONIST -> TARGET
The endogenous agonist
Structure of FG-9041
INHIBITOR -> TARGET
Structure of TALAMPANEL
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
Structure of SELURAMPANEL
INHIBITOR -> TARGET
Structure of AMPA H-3
RADIOLIGAND->TARGET
Structure of KAITOCEPHALIN
INHIBITOR -> TARGET
Structure of Perampanel
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
Structure of PESAMPATOR
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Structure of FANAPANEL
INHIBITOR -> TARGET
Structure of FARAMPATOR
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
Structure of TULRAMPATOR
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
High-impact AMPAR PAM decreases both deactivation and desensitization together to enhance and prolong synaptic currents.
Structure of OXIRACETAM
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
Structure of IRAMPANEL
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
Structure of THEANINE
INHIBITOR -> TARGET
Structure of MIBAMPATOR
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
High-impact AMPAR PAM decreases both deactivation and desensitization together to enhance and prolong synaptic currents.
Structure of DASOLAMPANEL
INHIBITOR -> TARGET
Structure of CX-546
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
Structure of CX-1739
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents.
Structure of CYANQUIXALINE
INHIBITOR -> TARGET
Structure of BECAMPANEL
INHIBITOR -> TARGET
Structure of HYDROXYNORKETAMINE, (2R,6R)-
ACTIVATOR -> TARGET
Structure of CYANQUIXALINE
INHIBITOR -> TARGET
Structure of LY-503430
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Structure of PIRACETAM
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
This action is very weak and its clinical effects may not necessarily be mediated by this action.
Structure of IBOTENIC ACID
AGONIST -> TARGET
Structure of ZONAMPANEL ANHYDROUS
INHIBITOR -> TARGET
Structure of MK-8777
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Structure of CX516
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
Structure of DOMOIC ACID
AGONIST -> TARGET
Structure of FK-960
AGONIST -> TARGET
Structure of GYKI-52466
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
Structure of PRAMIRACETAM
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents.
Structure of KYNURENIC ACID
INHIBITOR -> TARGET
Endogenous ligand
Structure of TEZAMPANEL
INHIBITOR -> TARGET
Structure of LY-404187
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
High-impact AMPAR PAM decreases both deactivation and desensitization together to enhance and prolong synaptic currents.
Structure of QUISQUALIC ACID
AGONIST -> TARGET
Structure of AMPA
AGONIST -> TARGET
Structure of CYCLOTHIAZIDE
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Structure of PF-4778574
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Structure of NBQX
INHIBITOR -> TARGET
Structure of L-WILLARDIINE
AGONIST -> TARGET
Structure of ANIRACETAM
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
Structure of CX-717
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents.
ALLOSTERIC ACTIVATOR
Structure of PEPA
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_836] [1_839] [1_856] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
NCATS
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