TYROSINE-PROTEIN KINASE JAK2 V617F MUTANT

Substance Class	Protein Created by `admin` on `Tue Apr 01 20:42:17 GMT 2025` Edited by `admin` on `Tue Apr 01 20:42:17 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	PKN4EXK2B8
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

Common Name

English

JAK2 V617F

Preferred Name

English

JANUS KINASE 2 V617F

Common Name

English

Code System Code Type Description

FDA UNII

PKN4EXK2B8

Created by admin on Tue Apr 01 20:42:17 GMT 2025 , Edited by admin on Tue Apr 01 20:42:17 GMT 2025

PRIMARY

Related Record Type Details


					G22N65IL3O

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					ANC71R916O

INHIBITOR -> TARGET


					6L1XP550I6

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_119] [1_372] [1_373] [1_813] [1_868] [1_966] [1_972] [1_1007] [1_1008]		TYROSINE		TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID SUBSTITUTION	[1_523]		SERINE		DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL