U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 02:31:22 GMT 2025
Edited
by admin
on Wed Apr 02 02:31:22 GMT 2025
Protein Type ENZYME
Protein Sub Type SERINE/THREONINE-PROTEIN KINASE
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
S0IV3JHN4Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AKT-1
Preferred Name English
RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
Common Name English
PKB ALPHA
Common Name English
PKB
Common Name English
PROTEIN KINASE B ALPHA
Common Name English
RAC-PK-ALPHA
Common Name English
PROTEIN KINASE B
Common Name English
RAC
Common Name English
PROTO-ONCOGENE C-AKT
Common Name English
Code System Code Type Description
PHAROS
P31749
Created by admin on Wed Apr 02 02:31:22 GMT 2025 , Edited by admin on Wed Apr 02 02:31:22 GMT 2025
PRIMARY
UNIPROT
P31749
Created by admin on Wed Apr 02 02:31:22 GMT 2025 , Edited by admin on Wed Apr 02 02:31:22 GMT 2025
PRIMARY
FDA UNII
S0IV3JHN4Z
Created by admin on Wed Apr 02 02:31:22 GMT 2025 , Edited by admin on Wed Apr 02 02:31:22 GMT 2025
PRIMARY
From To
1_60 1_77
1_296 1_310
Glycosylation Type HUMAN
Glycosylation Link Type Site
O 1_126
O 1_129
O 1_305
O 1_312
O 1_473
Related Record Type Details
Structure of GSK-690693
INHIBITOR -> TARGET
ATP competitive
IC50
Structure of CAPIVASERTIB
INHIBITOR -> TARGET
IC50
Structure of MIRANSERTIB
INHIBITOR -> TARGET
Structure of Rizavasertib
INHIBITOR -> TARGET
Structure of MBQ-167
INHIBITOR -> TARGET
Structure of BAY-1125976
INHIBITOR -> TARGET
at 10mM ATP and 44 nM at 2 mM ATP
Structure of PERIFOSINE
INHIBITOR -> TARGET
Inhibits phosphorylation of AKT presumably prevents IP3 binding.
Structure of AFURESERTIB
INHIBITOR -> TARGET
Structure of Pifusertib
INHIBITOR -> TARGET
Structure of Engasertib
INHIBITOR -> TARGET
ALLOSTERIC
Structure of TELMESTEINE
INHIBITOR -> TARGET
Structure of Rupitasertib
INHIBITOR -> TARGET
Structure of Phosphatidylinositol (3,4,5)-trisphosphate
ACTIVATOR -> TARGET
Structure of MK-2206 FREE BASE
INHIBITOR -> TARGET
ALLOSTERIC
IC50
Structure of VEVORISERTIB
INHIBITOR -> TARGET
ALLOSTERIC INHIBITOR
IC50
Structure of UPROSERTIB
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966