Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Wed Apr 02 13:37:49 GMT 2025
by
admin
on
Wed Apr 02 13:37:49 GMT 2025
|
| Protein Type | ENZYME |
| Protein Sub Type | TYROSINE KINASE |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
SWY4QNB42K
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
SWY4QNB42K
Created by
admin on Wed Apr 02 13:37:49 GMT 2025 , Edited by admin on Wed Apr 02 13:37:49 GMT 2025
|
PRIMARY |
| From | To |
|---|---|
| 1_109 | 1_114 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_70 |
| N | 1_123 |
| N | 1_171 |
| N | 1_308 |
| N | 1_315 |
| N | 1_333 |
| N | 1_339 |
| N | 1_349 |
| N | 1_366 |
| N | 1_420 |
| N | 1_440 |
| N | 1_526 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
INHIBITOR RESISTANT -> TARGET |
IC50
|
||
|
INHIBITOR -> TARGET |
IC50
|
||
|
INHIBITOR RESISTANT -> TARGET |
IC50
|
||
|
INHIBITOR -> TARGET |
Selpercatinib was found to be 60?1300-fold more effective than other MKIs against cell lines engineered with KIF5BRETV804L/M gatekeeper mutations.
IC50
|
||
|
INHIBITOR RESISTANT -> TARGET |
IC50
|
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| Molecular Formula | CHEMICAL |
|
||||
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
|