Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H19NOS |
| Molecular Weight | 297.415 |
| Optical Activity | ( - ) |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CNCC[C@@H](OC1=C2C=CC=CC2=CC=C1)C3=CC=CS3
InChI
InChIKey=ZEUITGRIYCTCEM-QGZVFWFLSA-N
InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m1/s1
| Molecular Formula | C18H19NOS |
| Molecular Weight | 297.415 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| R-Duloxetine and N-Methyl Duloxetine as Novel Analgesics Against Experimental Postincisional Pain. | 2016-03 |
|
| Development of chiral methodologies by capillary electrophoresis with ultraviolet and mass spectrometry detection for duloxetine analysis in pharmaceutical formulations. | 2014-10-10 |
|
| Investigation on the enantioseparation of duloxetine by capillary electrophoresis, NMR, and mass spectrometry. | 2014-10 |
|
| A chemoenzymatic dynamic kinetic resolution approach to enantiomerically pure (R)- and (S)-duloxetine. | 2011-05-20 |
Sample Use Guides
rat incision: Ipsilateral SC injections (2 mg/0.4 mL) of R-duloxetine reduced both postoperative allodynia and hyperalgesia by approximately 89% to 99% in the area under the curve of skin responses next to incision over 5 days. Systemic intraperitoneal injections at a higher dosage (10 mg) had smaller analgesic effects (reduced by approximately 53%-69%), whereas contralateral SC injections (10 mg) were ineffective.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:28:49 GMT 2025
by
admin
on
Mon Mar 31 21:28:49 GMT 2025
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| Record UNII |
TK9VOT90JQ
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| Record Status |
Validated (UNII)
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116539-60-7
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10334821
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DTXSID40151424
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TK9VOT90JQ
Created by
admin on Mon Mar 31 21:28:49 GMT 2025 , Edited by admin on Mon Mar 31 21:28:49 GMT 2025
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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RACEMATE -> ENANTIOMER |
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SALT/SOLVATE -> PARENT |
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| Related Record | Type | Details | ||
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PARENT -> IMPURITY |
