Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H8N2O2 |
| Molecular Weight | 152.1506 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C=CC(=O)C(=C1)C(N)=O
InChI
InChIKey=KTLRWTOPTKGYQY-UHFFFAOYSA-N
InChI=1S/C7H8N2O2/c1-9-3-2-6(10)5(4-9)7(8)11/h2-4H,1H3,(H2,8,11)
| Molecular Formula | C7H8N2O2 |
| Molecular Weight | 152.1506 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Simultaneous determination of nicotinic acid and its four metabolites in rat plasma using high performance liquid chromatography with tandem mass spectrometric detection (LC/MS/MS). | 2010-04-01 |
|
| Comparison of the nicotinamide catabolism among rat strains. | 2009-02 |
|
| Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver. | 2008-07 |
|
| Nicotinamide metabolites accumulate in the tissues of uremic rats. | 2008-01 |
|
| Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation. | 2007-08 |
|
| 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. | 2007-07-10 |
|
| Relationship between uremic toxins and oxidative stress in patients with chronic renal failure. | 2007 |
|
| Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure. | 2006-06 |
|
| Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH. | 2006-04 |
|
| Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats. | 2006-02 |
|
| Final report of the safety assessment of niacinamide and niacin. | 2005 |
|
| Conversion ratio of tryptophan to niacin in Japanese women fed a purified diet conforming to the Japanese Dietary Reference Intakes. | 2004-12 |
|
| Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography. | 2003-08-29 |
|
| Increase in conversion of tryptophan to niacin in pregnant rats. | 2003 |
|
| Identification of N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-5-carboxamide as components in urine extracts of individuals consuming coffee. | 2002-10-15 |
|
| Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats. | 2002-06 |
|
| [Effect of feeding with a poisonous mushroom Clitocybe acromelalga on the metabolism of tryptophan-niacin in rats]. | 2001-06 |
|
| Effects of dietary pyrazinamide, an antituberculosis agent, on the metabolism of tryptophan to niacin and of tryptophan to serotonin in rats. | 2001-06 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:55:52 GMT 2025
by
admin
on
Mon Mar 31 18:55:52 GMT 2025
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| Record UNII |
VE4S15CI8D
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| Record Status |
Validated (UNII)
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| Record Version |
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440810
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DTXSID80227697
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27838
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769-49-3
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VE4S15CI8D
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| Related Record | Type | Details | ||
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PARENT -> METABOLITE |
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PARENT -> METABOLITE TOXIC |
Promotes vascular inflammation and contributes to cardiovascular disease risk.
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